Multifunctional Bio-Scaffolds for Cell Growth and Tissue Morphogenesis

Dear Colleagues,

Advanced tissue engineering strategies aim to restore the functionalities of damaged and/or dysfunctional tissues and organs by the sapient combination and integration of biomaterials, cells, and bioactive molecules. The synergy and interplay among these three elements contribute to the truthful formation of mechanically stable and biochemically functional biodegradable and bioactive scaffolds (bio-scaffolds) toward new tissue growth and morphogenesis. Traditionally, bioscaffolds can be obtained via cell transplantation into the pores of a three-dimensionally porous monolith. More recently, computer-aided design and manufacturing (CAD-CAM) processes, such as bioprinting and VAT polymerization, have emerged as a promising strategy to simultaneously process biomaterials, cells, and bioactive molecules to obtain bioscaffolds following tissue- and patient-specific biomimetic designs. The aim of this Special Issue is to collect articles presenting state-of-the-art knowledge on bioscaffold design, processing, and validation as shared by experts in these research fields. Special emphasis will be devoted to cutting-edge research regarding technological advancements of (i) biomaterial (e.g., biodegradable polyesters and hydrogels) design and processing with micro- and nanometric scale control of biochemical and architectural properties; (ii) bioactive molecule (e.g., growth factor) loading and release from bioscaffolds; (iii) cell behavior and tissue morphogenesis within bioscaffolds.

Dr. Aurelio Salerno
Dr. Alfredo Ronca
Dr. Anna Abbadessa
Guest Editors

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