5 Results Found

Advanced Search

Select all

Results per page

Select all

Article

17 Citations

5,820 Views

14 Pages

A Sample and Sensitive HPLC-MS/MS Method for Simultaneous Determination of Ziyuglycoside I and Its Metabolite Ziyuglycoside II in Rat Pharmacokinetics

Zhi-Feng Li,
Meng-Ying Zhou,
Ting Tan,
Chen-Cong Zhong and ,
Qi Wang,
Ling-Ling Pan,
Ying-Ying Luo,
Shi-Lin Yang,
Yu-Lin Feng and
Hui Ouyang
+ 5 authors+ 0 author

Molecules2018, 23(3), 543;https://doi.org/10.3390/molecules23030543

28 February 2018

Ziyuglycoside I (ZGS1) is a promising drug candidate for the treatment of leucopenia. Currently, information on ZGS1 and its in vivo metabolite ziyuglycoside II (ZGS2) is limited. The objective of this study was to investigate the pharmacokinetics, t...

Full Article

Article

49 Citations

11,652 Views

15 Pages

Ziyuglycoside II Inhibits the Growth of Human Breast Carcinoma MDA-MB-435 Cells via Cell Cycle Arrest and Induction of Apoptosis through the Mitochondria Dependent Pathway

Xue Zhu,
Ke Wang,
Kai Zhang,
Biao Huang and ,
Jue Zhang,
Yi Zhang,
Lan Zhu,
Bin Zhou and
Fanfan Zhou
+ 4 authors+ 0 author

Int. J. Mol. Sci.2013, 14(9), 18041-18055;https://doi.org/10.3390/ijms140918041

3 September 2013

Ziyuglycoside II is one of the major active compounds of Sanguisorba officinalis L., which has a wide range of clinical applications including hemostasis, antibiosis, anti-inflammation and anti-oxidation. This study investigated the effect of ziyugl...

(This article belongs to the Section Biochemistry)

Full Article

Article

3 Citations

2,119 Views

24 Pages

Calcium/Aluminum-Cored Asymmetric Bilayer Nanoparticles for Codelivery of Ziyuglycoside II and PD-L1 siRNA Exert Anti-Breast Tumor Effects

Xiang Li,
Xiangping Wu,
Weiqiang Su,
Nina Filipczak and ,
Satya Siva Kishan Yalamarty,
Wenhao Jiang,
Dongyun Tao,
Shiyun Yang and
Jing Zhang
+ 4 authors+ 0 author

Pharmaceutics2026, 18(2), 268;https://doi.org/10.3390/pharmaceutics18020268

22 February 2026

Objectives Breast cancer remains a major cause of female cancer-related deaths, with current therapies limited by poor tumor targeting and an immunosuppressive microenvironment. This study designed CA/ZYII-siP-c-L—an asymmetric lipid bilayer-co...

(This article belongs to the Special Issue Hybrid Nanoparticles for Cancer Therapy)

Full Article

Article

42 Citations

7,878 Views

15 Pages

Anti-Diabetic and Hepato-Renal Protective Effects of Ziyuglycoside II Methyl Ester in Type 2 Diabetic Mice

Dong Ju Son,
Seock Yeon Hwang,
Myung-Hyun Kim,
Un Kyu Park and
Byoung Soo Kim

Nutrients2015, 7(7), 5469-5483;https://doi.org/10.3390/nu7075232

7 July 2015

Type 2 diabetes is a metabolic disorder caused by abnormal carbohydrate metabolism, and closely associated with abnormal lipid metabolism and hepato-renal dysfunction. This study investigated the anti-diabetic and hepato-renal protective properties o...

(This article belongs to the Special Issue Natural Products for Human Health)

Full Article

Article

20 Citations

4,094 Views

15 Pages

Simultaneous Determination and Pharmacokinetics Study of Six Triterpenes in Rat Plasma by UHPLC-MS/MS after Oral Administration of Sanguisorba officinalis L. Extract

Chengcui Wu,
Meicun Yao,
Wa Li,
Binbin Cui and ,
Hongrui Dong,
Yixuan Ren,
Chunjuan Yang and
Chunli Gan
+ 3 authors+ 0 author

Molecules2018, 23(11), 2980;https://doi.org/10.3390/molecules23112980

15 November 2018

A selective and sensitive ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed and validated for the determination of ziyuglycoside I (I), 3β,19α-dihydroxyurs-12-en-28-oic-acid 28-β-...

Full Article