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Nutrients 2015, 7(7), 5469-5483;

Anti-Diabetic and Hepato-Renal Protective Effects of Ziyuglycoside II Methyl Ester in Type 2 Diabetic Mice

College of Pharmacy & Medical Research Center, Chungbuk National University, Cheongju, Chungbuk 361-951, Korea
Department of Biomedical Laboratory Science, College of Natural Science, Daejeon University, Daejeon 300-716, Korea
Department of Physiology, College of Korean Medicine, Daejeon University, Daejeon 300-716, Korea
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 4 April 2015 / Revised: 21 May 2015 / Accepted: 25 June 2015 / Published: 7 July 2015
(This article belongs to the Special Issue Natural Products for Human Health)
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Type 2 diabetes is a metabolic disorder caused by abnormal carbohydrate metabolism, and closely associated with abnormal lipid metabolism and hepato-renal dysfunction. This study investigated the anti-diabetic and hepato-renal protective properties of ziyuglycoside I (ZG01) derivative on type 2 diabetes. ZG01 was isolated from roots of Sanguisorba officinalis and chemically modified by deglycosylation and esterification to obtained ziyuglycoside II methyl ester (ZG02-ME). Here, we showed that ZG02-ME has stronger anti-diabetic activity than the original compound (ZG01) through decreasing blood glucose, glycated hemoglobin (HbA1c), and insulin levels in a mouse model of type 2 diabetes (db/db mice). We further found that ZG02-ME treatment effectively ameliorated serum insulin, leptin and C-peptide levels, which are key metabolic hormones, in db/db mice. In addition, we showed that elevated basal blood lipid levels were decreased by ZG02-ME treatment in db/db mice. Furthermore, treatment of ZG02-ME significantly decreased serum AST, ALT, BUN, creatinine, and liver lipid peroxidation in db/db mice. These results demonstrated that compared to ZG01, chemically modified ZG02-ME possess improved anti-diabetic properties, and has hepato-renal protective activities in type 2 diabetes. View Full-Text
Keywords: ziyuglycoside; Sanguisorba officinalis; diabetes; diabetic hepatopathy; diabetic nephropathy ziyuglycoside; Sanguisorba officinalis; diabetes; diabetic hepatopathy; diabetic nephropathy

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Son, D.J.; Hwang, S.Y.; Kim, M.-H.; Park, U.K.; Kim, B.S. Anti-Diabetic and Hepato-Renal Protective Effects of Ziyuglycoside II Methyl Ester in Type 2 Diabetic Mice. Nutrients 2015, 7, 5469-5483.

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