You are currently on the new version of our website. Access the old version .

17 Results Found

  • Article
  • Open Access
11 Citations
3,398 Views
19 Pages

Untargeted Metabolomics Revealed Potential Biomarkers of Small Yellow Follicles of Chickens during Sexual Maturation

  • Jinbo Zhao,
  • Hongbin Pan,
  • Wenjiang Zhao,
  • Wei Li,
  • Haojie Li,
  • Zhongxiao Tian,
  • Dayong Meng,
  • Yuting Teng,
  • Xinlu Li and
  • Kun Wang
  • + 3 authors

26 January 2023

Sexual maturation provides economically important traits in poultry production. Research on the initiation mechanism of sexual maturity is of great significance for breeding high-yield laying hens. However, the underlying mechanisms are not fully cle...

  • Article
  • Open Access
35 Citations
6,350 Views
18 Pages

Morphological Characteristics and Transcriptome Landscapes of Chicken Follicles during Selective Development

  • Ruixue Nie,
  • Xiaotong Zheng,
  • Wenhui Zhang,
  • Bo Zhang,
  • Yao Ling,
  • Hao Zhang and
  • Changxin Wu

11 March 2022

Ovarian follicle selection largely depends on the transition of granulosa cells from an undifferentiated to a fully differentiated state, which is accompanied by morphological and functional changes in follicles. The processes and transcriptional reg...

  • Article
  • Open Access
4 Citations
2,481 Views
13 Pages

Transcriptome Profiling of Goose Ovarian Follicle Granulosa Cells Reveals Key Regulatory Networks for Follicle Selection

  • Jie Liu,
  • Shudi Dai,
  • Zichun Dai,
  • Yuyan Feng,
  • Mingming Lei,
  • Rong Chen and
  • Huanxi Zhu

28 June 2023

The selection of follicles determines the reproductive performance of birds, but the process of follicle selection in geese is still elusive. This study focuses on Yangzhou geese during the egg-laying period and divides the follicular development pro...

  • Article
  • Open Access
2 Citations
1,603 Views
15 Pages

19 October 2024

Transfer RNA-derived small RNAs (tsRNAs) are novel regulatory small non-coding RNAs that have been found to modulate many life activities in recent years. However, the exact functions of tsRNAs in follicle development remain unclear. Follicle develop...

  • Article
  • Open Access
3 Citations
2,275 Views
20 Pages

Genomically Selected Genes Associated with a High Rate of Egg Production in Puan Panjiang Black-Bone Chickens

  • Xiaomeng Miao,
  • Zhiying Huang,
  • Jia Liu,
  • Li Zhang,
  • Yulong Feng,
  • Yalan Zhang,
  • Diyan Li and
  • Zhonghua Ning

27 January 2025

Puan Panjiang black-bone chickens are renowned for their distinctive traits, deep black coloration, and high-quality protein content, making them a focus of genetic research due to their unique egg-laying abilities. In this study, 110 Puan Panjiang b...

  • Article
  • Open Access
15 Citations
3,007 Views
18 Pages

1α,25-Dihydroxyvitamin D3 (VitD3) is the active form of vitamin D, and it regulates gene expression and protein synthesis in mammalian follicle development. However, the function of VitD3 in the follicular development of layers remains unclear....

  • Article
  • Open Access
1 Citations
1,077 Views
17 Pages

28 February 2025

The development and selection of ovarian follicles are essential for continuous egg production in chickens. Non-coding RNAs, particularly circular RNAs (circRNAs), play a critical regulatory role in follicle selection, a process heavily involving gra...

  • Article
  • Open Access
31 Citations
3,721 Views
13 Pages

Transcriptome Analysis of circRNA and mRNA in Theca Cells during Follicular Development in Chickens

  • Manman Shen,
  • Ping Wu,
  • Tingting Li,
  • Pengfei Wu,
  • Fuxiang Chen,
  • Lan Chen,
  • Kaizhou Xie,
  • Jinyu Wang and
  • Genxi Zhang

29 April 2020

Development of ovarian follicles requires interactions between granulosa cells, theca cells, and oocytes. Multiple transcription levels are involved but information about the role of noncoding RNAs, especially circular RNAs (circRNAs), is lacking. He...

  • Article
  • Open Access
15 Citations
3,472 Views
15 Pages

Dynamic Expression Profile of Follicles at Different Stages in High- and Low-Production Laying Hens

  • Lan Yang,
  • Xuewei Fan,
  • Kaiyuan Tian,
  • Sensen Yan,
  • Chunhong Xu,
  • Yixiang Tian,
  • Chengpeng Xiao,
  • Xintao Jia,
  • Junlai Shi and
  • Wenting Li
  • + 1 author

26 December 2023

Improving the efficiency of hens and extending the egg-laying cycle require maintaining high egg production in the later stages. The ovarian follicles, as the primary functional units for ovarian development and oocyte maturation, play a crucial role...

  • Article
  • Open Access
15 Citations
3,954 Views
10 Pages

23 June 2021

The purpose of this study was to evaluate the effects of royal jelly (RJ) on the morphology of the reproductive tract, egg production, and blood biochemical indices of aged laying hens. In total, 120 Lohman Brown laying hens at week 58 of age were ra...

  • Article
  • Open Access
7 Citations
2,823 Views
15 Pages

Transcriptome Analysis of Granulosa Cells Reveals Regulatory Mechanisms Related to Chicken Follicle Development

  • Xubin Du,
  • Qizhao Zhu,
  • Huifang Pian,
  • Xiaolong Yang,
  • Dong Zhao,
  • Xinyue Wu,
  • Jiawen He and
  • Debing Yu

20 December 2023

In this study, we aimed to better understand the difference between the functions of the two types of granulosa cells and sought to discover more key genes involved in follicle development and follicle selection. Herein, we separately collected pre-h...

  • Article
  • Open Access
2 Citations
744 Views
26 Pages

15 November 2025

Egg-laying performance in hens is regulated by complex molecular mechanisms within the hypothalamic–pituitary–gonadal (HPG) axis and ovarian follicles. This study employed integrative transcriptome profiling of primordial (PR), primary (P...

  • Article
  • Open Access
16 Citations
3,086 Views
21 Pages

Bioactive Lignan Honokiol Alleviates Ovarian Oxidative Stress in Aging Laying Chickens by Regulating SIRT3/AMPK Pathway

  • Yiqiu Chen,
  • Zhaoyu Yang,
  • Jingchun Bai,
  • Xinyu Wang,
  • Qiongyu Yuan,
  • Yuling Mi and
  • Caiqiao Zhang

Aging is not only a key internal cause of age-related diseases in humans but also poses a threat to the productivity of farm animals with longer breeding cycles, such as laying chickens. Various measures were taken to prolong the laying period by red...

  • Article
  • Open Access
7 Citations
2,294 Views
11 Pages

1 October 2022

The signaling pathway of the wingless-type mouse mammary tumor virus integration site (Wnt) plays an important role in ovarian and follicular development. In our previous study, WNT4 was shown to be involved in the selection and development of chicke...

  • Article
  • Open Access
1 Citations
1,074 Views
21 Pages

30 October 2025

Oxidative stress-mediated dysfunction of granulosa cells (GCs) is recognized as a pivotal driver of prehierarchical follicular atresia in poultry, contributing substantially to the reduced egg production in aged laying hens. Here, we investigated the...

  • Article
  • Open Access
2 Citations
1,317 Views
27 Pages

Attenuating Effect of a Polyphenol Ellagic Acid on Ovarian Aging by Inhibiting the Ferroptosis Pathway in Low-Yield Laying Chickens

  • Qiongyu Yuan,
  • Xinyu Wang,
  • Yingyu Xiao,
  • Zhaoyu Yang,
  • Xiangyu Cai,
  • Wanyue Gao,
  • Yuling Mi and
  • Caiqiao Zhang

Aging leads to ovarian degeneration in poultry, reducing egg production and quality. Ellagic acid (EA), a natural plant-derived compound, may help delay ovarian aging, though its precise mechanisms remain unclear. This study investigated the effects...

  • Article
  • Open Access
3 Citations
2,582 Views
21 Pages

The seed production of small yellow croaker (SYC) is constrained by reproductive dysfunction in captive-reared females. Reproductive dysfunction is closely linked to endocrine reproductive mechanisms. To better understand the reproductive dysfunction...