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14 Results Found

  • Article
  • Open Access
5 Citations
3,391 Views
15 Pages

20 December 2022

Parishin compounds are rare polyphenolic glucosides mainly found in the rhizome of the traditional Chinese medicinal plant, Gastrodia elata. These constituents are reported to have several biological and pharmacological activities. In the present stu...

  • Article
  • Open Access
12 Citations
6,332 Views
11 Pages

10 November 2017

Gastrodia elata Blume, called Tianma in China, has been widely used to treat headaches, convulsions and epilepsy for thousands of years. In the present study, a series of optimizations were employed to develop a rapid, sensitive, and reliable high-pe...

  • Article
  • Open Access
9 Citations
1,989 Views
14 Pages

Parishin A Inhibits Oral Squamous Cell Carcinoma via the AKT/mTOR Signaling Pathway

  • Lei Ma,
  • Zhibin Liu,
  • Eungyung Kim,
  • Ke Huang,
  • Chae Yeon Kim,
  • Hyeonjin Kim,
  • Kanghyun Park,
  • Woo-Sung Kwon,
  • Sang In Lee and
  • Myoung Ok Kim
  • + 4 authors

26 September 2024

Background: Oral squamous cell carcinoma (OSCC) is an aggressive cancer with limited treatment options. Parishin A, a natural compound derived from Gastrodia elata, possesses multiple therapeutic properties. However, its effects on OSCC remain unexpl...

  • Article
  • Open Access
2 Citations
2,053 Views
16 Pages

Parishin C (PaC) is an active ingredient in Gastrodia elata Bl. that has neuroprotective effects. However, research on its role in oxidative stress and neuroinflammation is still limited. This study used LPS–stimulated HT22 cells to investigate...

  • Article
  • Open Access
3 Citations
3,311 Views
12 Pages

pH as a Key Factor for the Quality Assurance of the Preparation of Gastrodiae Rhizoma Formula Granules

  • Shuting Xie,
  • Ke Min,
  • Hai Li,
  • Ying Wang,
  • Mincong Liu,
  • Ming Ma,
  • Desheng Zhou,
  • Haijun Tu and
  • Bo Chen

21 November 2022

Gastrodiae rhizoma (GR) formula granules and preparations have been used as a popular traditional Chinese medicine for clinical treatment since they have good pharmacological activity to treat nervous system diseases. Gastrodin and parishins have bee...

  • Article
  • Open Access
26 Citations
6,026 Views
17 Pages

Comparison of Bioactive Compounds and Antioxidant Activities of Maclura tricuspidata Fruit Extracts at Different Maturity Stages

  • Dae-Woon Kim,
  • Won-Jae Lee,
  • Yoseph Asmelash Gebru,
  • Han-Seok Choi,
  • Soo-Hwan Yeo,
  • Young-Jae Jeong,
  • Seung Kim,
  • Young-Hoi Kim and
  • Myung-Kon Kim

4 February 2019

Maclura tricuspidata fruit contains various bioactive compounds and has traditionally been used in folk medicine and as valuable food material in Korea. The composition and contents of bioactive compounds in the fruit can be influenced by its maturit...

  • Article
  • Open Access
141 Views
19 Pages

Gastrodia elata is a fully mycoheterotrophic orchid whose tuber development depends on carbon delivered by Armillaria fungi. Its formal inclusion in China’s “medicine and food homology” catalog has intensified demand for cultivated...

  • Article
  • Open Access
71 Citations
6,840 Views
16 Pages

17 April 2019

Gastrodia elata (G. elata) tuber is a valuable herbal medicine used to treat many diseases. The procedure of establishing a reasonable and feasible quality assessment method for G. elata tuber is important to ensure its clinical safety and efficacy....

  • Article
  • Open Access
23 Citations
5,219 Views
14 Pages

Optimal Extraction Study of Gastrodin-Type Components from Gastrodia Elata Tubers by Response Surface Design with Integrated Phytochemical and Bioactivity Evaluation

  • Minhui Hu,
  • Hui Yan,
  • Yuanyuan Fu,
  • Yulan Jiang,
  • Weifeng Yao,
  • Sheng Yu,
  • Li Zhang,
  • Qinan Wu,
  • Anwei Ding and
  • Mingqiu Shan

2 February 2019

Gastrodia elata tuber (GET) is a popular traditional Chinese medicines (TCMs). In this study, response surface methodology (RSM) with a Box–Behnken design (BBD) was performed to optimize the extraction parameters of gastrodin-type components (g...

  • Article
  • Open Access
662 Views
13 Pages

14 November 2025

Gastrodiae Rhizoma (GR) is known to have a medicinal and food-based homology. It is used to treat infantile convulsion, epilepsy, spasm, tetanus, and vertigo. In this study, an ultra-high performance liquid chromatography/tandem mass spectrometry (UH...

  • Article
  • Open Access
48 Citations
5,950 Views
14 Pages

Transformation Mechanisms of Chemical Ingredients in Steaming Process of Gastrodia elata Blume

  • Yun Li,
  • Xiao-Qian Liu,
  • Shan-Shan Liu,
  • Da-hui Liu,
  • Xiao Wang and
  • Zhi-Min Wang

30 August 2019

To explore the transformation mechanisms of free gastrodin and combined gastrodin before and after steaming of Gastrodia elata (G. elata), a fresh G. elata sample was processed by the traditional steaming method prescribed by Chinese Pharmacopoeia (2...

  • Article
  • Open Access
25 Citations
5,512 Views
11 Pages

29 January 2018

Gastrodia elata Blume (G. elata), a traditional Chinese medicine, is widely used for treatment of various neuro dysfunctions. However, its quality control is still limited to the determination of gastrodin. In the present study, two novel strategies...

  • Article
  • Open Access
7 Citations
3,460 Views
14 Pages

Gastrodia elata (Orchidaceae) is native to mountainous areas of Asia and is a plant species used in traditional medicine for more than two thousand years. The species was reported to have many biological activities, such as neuroprotective, antioxida...

  • Article
  • Open Access
22 Citations
6,337 Views
19 Pages

Phytochemical Analysis, Network Pharmacology and in Silico Investigations on Anacamptis pyramidalis Tuber Extracts

  • Mohamad Fawzi Mahomoodally,
  • Marie Carene Nancy Picot-Allain,
  • Gokhan Zengin,
  • Eulogio J. Llorent-Martínez,
  • Hassan H. Abdullah,
  • Gunes Ak,
  • Ismail Senkardes,
  • Annalisa Chiavaroli,
  • Luigi Menghini and
  • Claudio Ferrante
  • + 4 authors

Anacamptis pyramidalis (L.) Rich. forms part of the Orchidaceae family that is highly valued for its horticultural as well as therapeutic benefits. The present study set out to investigate the inhibitory activity of A. pyramidalis tubers against key...