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  • Article
  • Open Access
1,973 Views
20 Pages

Background: To address limitations in static cold storage (SCS) of donor hearts, we developed the High-Pressure Gaseous Perfusion without Fluidic Preservation Media (HIPPER) method, along with the necessary equipment for its application. Methods: 33...

(This article belongs to the Section Cardiovascular Pathophysiology)
  • Review
  • Open Access
6 Citations
5,912 Views
17 Pages

Persufflation—Current State of Play

  • Aaron John Buhagiar,
  • Leo Freitas and
  • William E. Scott

With the ever-increasing disparity between the number of patients waiting for organ transplants and the number organs available, some patients are unable to receive life-saving transplantation in time. The present, widely-used form of preservation is...

(This article belongs to the Special Issue Machine Perfusion in Organ Transplantation)
  • Review
  • Open Access
24 Citations
7,411 Views
20 Pages

The Role of Nitric Oxide in Cancer Treatment: Ally or Foe?

  • Angelika Myśliwiec,
  • Dorota Bartusik-Aebisher and
  • David Aebisher

29 June 2025

Nitric oxide (NO), the first gaseous molecule identified as a signaling mediator, plays a pivotal role in numerous physiological processes including cardiovascular regulation, immune response, and neurotransmission. Synthesized from L-arginine by nit...

(This article belongs to the Special Issue Molecular Approaches to Drug Discovery and Development)