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12 Results Found

  • Perspective
  • Open Access
16 Citations
10,112 Views
21 Pages

Could Global Intensification of Nitrogen Fertilisation Increase Immunogenic Proteins and Favour the Spread of Coeliac Pathology?

  • Josep Penuelas,
  • Albert Gargallo-Garriga,
  • Ivan A. Janssens,
  • Philippe Ciais,
  • Michael Obersteiner,
  • Karel Klem,
  • Otmar Urban,
  • Yong-Guan Zhu and
  • Jordi Sardans

4 November 2020

Fertilisation of cereal crops with nitrogen (N) has increased in the last five decades. In particular, the fertilisation of wheat crops increased by nearly one order of magnitude from 1961 to 2010, from 9.84 to 93.8 kg N ha−1 y−1. We hypo...

  • Article
  • Open Access
7 Citations
3,616 Views
12 Pages

Long-Term Effect of a Gluten-Free Diet on Diarrhoea- or Bloating-Predominant Functional Bowel Disease: Role of the ‘Low-Grade Coeliac Score’ and the ‘Coeliac Lymphogram’ in the Response Rate to the Diet

  • Fernando Fernández-Bañares,
  • Beatriz Arau,
  • Agnès Raga,
  • Montserrat Aceituno,
  • Eva Tristán,
  • Anna Carrasco,
  • Laura Ruiz,
  • Albert Martín-Cardona,
  • Pablo Ruiz-Ramírez and
  • Maria Esteve

26 May 2021

1. Background: The long-term effect of a gluten-free diet (GFD) on functional bowel disorders (FBDs) has been scarcely studied. The aim was to assess the effect of a GFD on FBD patients, and to assess the role of both the low-grade coeliac score and...

  • Article
  • Open Access
1,624 Views
19 Pages

Duodenal Biopsy Audit: Relative Frequency of Diagnoses, Key Words on Request Forms Indicating Severe Pathology, and Potential Diagnoses for Intraepithelial Lymphocytosis, as a Foundation for Developing Artificial Intelligence Diagnostic Approaches

  • Vrinda Shenoy,
  • Jessica L. James,
  • Amelia B. Williams-Walker,
  • Nasyen P. R. Madhan Mohan,
  • Kim N. Luu Hoang,
  • Josephine Williams,
  • Florian Jaeckle,
  • Shelley C. Evans and
  • Elizabeth J. Soilleux

Background/Objectives: Understanding the diagnostic landscape is essential prior to developing artificial intelligence (AI)-based diagnostic strategies for automating the diagnosis of duodenal biopsies. This study aims to (1) determine the frequencie...

  • Review
  • Open Access
13 Citations
6,495 Views
23 Pages

Spotlight on the Transglutaminase 2-Heparan Sulfate Interaction

  • Giulia Furini and
  • Elisabetta A.M. Verderio

4 January 2019

Heparan sulfate proteoglycans (HSPGs), syndecan-4 (Sdc4) especially, have been suggested as potential partners of transglutaminase-2 (TG2) in kidney and cardiac fibrosis, metastatic cancer, neurodegeneration and coeliac disease. The proposed role for...

  • Review
  • Open Access
36 Citations
8,917 Views
17 Pages

The Neuropathology of Gluten-Related Neurological Disorders: A Systematic Review

  • Maxine D Rouvroye,
  • Panagiotis Zis,
  • Anne-Marie Van Dam,
  • Annemieke J.M. Rozemuller,
  • Gerd Bouma and
  • Marios Hadjivassiliou

20 March 2020

Gluten-related neurological disorders (GRND) represent a spectrum of neurological manifestations that are triggered by gluten. In coeliac disease, a T-cell mediated enteropathy is triggered by gluten in genetically predisposed individuals. The underl...

  • Review
  • Open Access
26 Citations
14,225 Views
19 Pages

Gluten and Autism Spectrum Disorder

  • Iain D. Croall,
  • Nigel Hoggard and
  • Marios Hadjivassiliou

9 February 2021

An expanding body of literature is examining connections between Autism Spectrum Disorder (ASD) and dietary interventions. While a number of specialist diets have been suggested as beneficial in ASD, gluten has received particularly close attention a...

  • Article
  • Open Access
50 Citations
4 Views
5 Pages

Parenting Stress and Impact of Illness in Parents of Children with Coeliac Disease

  • Maria Stella Epifanio,
  • Vitalba Genna,
  • Maria Grazia Vitello,
  • Michele Roccella and
  • Sabina La Grutta

19 December 2013

Coeliac disease (CD) is a chronic disease which could stress patients and their family. Although, poor attention has been paid to the quality of life in CD children and to the functioning of families with CD children. The study aims to evaluate the p...

  • Review
  • Open Access
4 Citations
2,733 Views
10 Pages

Virtual Chromoendoscopy in Capsule Endoscopy: A Narrative Review

  • Alexandros Toskas,
  • Faidon-Marios Laskaratos and
  • Sergio Coda

The usefulness of virtual chromoendoscopy (VC) in capsule endoscopy (CE) isa controversial issue, with conflicting studies regarding its efficacy. FICE and a blue filter were embedded in the PillCamTM software, with the aim to assist readers in ident...

  • Review
  • Open Access
23 Citations
4,684 Views
16 Pages

Small Bowel Carcinomas Associated with Immune-Mediated Intestinal Disorders: The Current Knowledge

  • Paolo Giuffrida,
  • Alessandro Vanoli,
  • Giovanni Arpa,
  • Arturo Bonometti,
  • Ombretta Luinetti,
  • Enrico Solcia,
  • Gino Roberto Corazza,
  • Marco Paulli and
  • Antonio Di Sabatino

29 December 2018

Small bowel carcinomas (SBC) are uncommon neoplasms, whose predisposing conditions include hereditary syndromes and immune-mediated intestinal disorders including coeliac disease (CD) and Crohn’s disease (CrD). Although both CD-associated SBC (...

  • Brief Report
  • Open Access
4 Citations
2,720 Views
8 Pages

Sensory Symptoms without Structural Pathology in Patients with Gluten Sensitivity

  • Marios Hadjivassiliou,
  • Nick Trott,
  • Nigel Hoggard and
  • David S. Sanders

19 April 2024

We report on a group of patients with gluten sensitivity with and without coeliac disease presenting with unexplained sensory symptoms in the absence of structural pathology. Methods: The patients were selected from the gluten neurology clinic based...

  • Article
  • Open Access
1,229 Views
10 Pages

Temporary Flow Diversion in Oncological Embolization Procedures Using Degradable Starch Microspheres

  • Francesco Giurazza,
  • Pierleone Lucatelli,
  • Fabio Corvino,
  • Renato Argirò,
  • Pietro Roccatagliata,
  • Anna Maria Ierardi and
  • Raffaella Niola

17 December 2024

Objectives: This study aims to report on the application of degradable starch microspheres to provide flow diversion by means of temporary embolization of healthy tissues in oncological endovascular procedures when tumor feeding vessels are not selec...

  • Article
  • Open Access
7 Citations
3,664 Views
14 Pages

Gene Expression Profiling in Coeliac Disease Confirmed the Key Role of the Immune System and Revealed a Molecular Overlap with Non-Celiac Gluten Sensitivity

  • Michele Sallese,
  • Konstantinos Efthymakis,
  • Michele Marchioni,
  • Benedetto Neri,
  • Beatrice Dufrusine,
  • Enrico Dainese,
  • Marta Di Nicola and
  • Matteo Neri

Coeliac disease (CeD) is an immune-mediated disorder triggered by the ingestion of gluten and an as yet unidentified environmental factor in genetically predisposed individuals. The disease involves a major autoimmune component that primarily damages...