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Transglutaminases in Monocytes and Macrophages
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Spotlight on the Transglutaminase 2-Heparan Sulfate Interaction

School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK
BiGeA, University of Bologna, 40126 Bologna, Italy
Author to whom correspondence should be addressed.
Med. Sci. 2019, 7(1), 5;
Received: 8 November 2018 / Revised: 17 December 2018 / Accepted: 18 December 2018 / Published: 4 January 2019
(This article belongs to the Special Issue Transglutaminases in Health and Disease)
Heparan sulfate proteoglycans (HSPGs), syndecan-4 (Sdc4) especially, have been suggested as potential partners of transglutaminase-2 (TG2) in kidney and cardiac fibrosis, metastatic cancer, neurodegeneration and coeliac disease. The proposed role for HSPGs in the trafficking of TG2 at the cell surface and in the extracellular matrix (ECM) has been linked to the fibrogenic action of TG2 in experimental models of kidney fibrosis. As the TG2-HSPG interaction is largely mediated by the heparan sulfate (HS) chains of proteoglycans, in the past few years a number of studies have investigated the affinity of TG2 for HS, and the TG2 heparin binding site has been mapped with alternative outlooks. In this review, we aim to provide a compendium of the main literature available on the interaction of TG2 with HS, with reference to the pathological processes in which extracellular TG2 plays a role. View Full-Text
Keywords: transglutaminase-2 (TG2); heparan sulfate proteoglycans (HSPGs); syndecan-4 (Sdc4); fibrosis transglutaminase-2 (TG2); heparan sulfate proteoglycans (HSPGs); syndecan-4 (Sdc4); fibrosis
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Furini, G.; Verderio, E.A. Spotlight on the Transglutaminase 2-Heparan Sulfate Interaction. Med. Sci. 2019, 7, 5.

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