Next Article in Journal
Effectiveness of a Two-Step Testing Algorithm for Reliable and Cost-Effective Detection of Clostridium difficile Infection in a Tertiary Care Hospital in Saudi Arabia
Next Article in Special Issue
The Role of Tissue Transglutaminase in Cancer Cell Initiation, Survival and Progression
Previous Article in Journal
Analysis of Antioxidant Consumption, Body Mass Index and the Waist-Hip Ratio in Early Postmenopause
Previous Article in Special Issue
Transglutaminases in Monocytes and Macrophages
Open AccessReview

Spotlight on the Transglutaminase 2-Heparan Sulfate Interaction

1
School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK
2
BiGeA, University of Bologna, 40126 Bologna, Italy
*
Author to whom correspondence should be addressed.
Med. Sci. 2019, 7(1), 5; https://doi.org/10.3390/medsci7010005
Received: 8 November 2018 / Revised: 17 December 2018 / Accepted: 18 December 2018 / Published: 4 January 2019
(This article belongs to the Special Issue Transglutaminases in Health and Disease)
Heparan sulfate proteoglycans (HSPGs), syndecan-4 (Sdc4) especially, have been suggested as potential partners of transglutaminase-2 (TG2) in kidney and cardiac fibrosis, metastatic cancer, neurodegeneration and coeliac disease. The proposed role for HSPGs in the trafficking of TG2 at the cell surface and in the extracellular matrix (ECM) has been linked to the fibrogenic action of TG2 in experimental models of kidney fibrosis. As the TG2-HSPG interaction is largely mediated by the heparan sulfate (HS) chains of proteoglycans, in the past few years a number of studies have investigated the affinity of TG2 for HS, and the TG2 heparin binding site has been mapped with alternative outlooks. In this review, we aim to provide a compendium of the main literature available on the interaction of TG2 with HS, with reference to the pathological processes in which extracellular TG2 plays a role. View Full-Text
Keywords: transglutaminase-2 (TG2); heparan sulfate proteoglycans (HSPGs); syndecan-4 (Sdc4); fibrosis transglutaminase-2 (TG2); heparan sulfate proteoglycans (HSPGs); syndecan-4 (Sdc4); fibrosis
Show Figures

Figure 1

MDPI and ACS Style

Furini, G.; Verderio, E.A. Spotlight on the Transglutaminase 2-Heparan Sulfate Interaction. Med. Sci. 2019, 7, 5.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop