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20 Results Found

  • Review
  • Open Access
5 Citations
6,101 Views
17 Pages

Arrhythmic Mitral Valve Prolapse: A Comprehensive Review

  • Yuyan Deng,
  • Jinfeng Liu,
  • Shan Wu,
  • Xiaoming Li,
  • Huimei Yu,
  • Lili Tang,
  • Meng Xie and
  • Chun Zhang

6 September 2023

Mitral valve prolapse (MVP) is a prevalent cardiac disorder that impacts approximately 2% to 3% of the overall population. While most patients experience a benign clinical course, there is evidence suggesting that a subgroup of MVP patients face an i...

  • Review
  • Open Access
4 Citations
9,370 Views
24 Pages

Arrhythmic Mitral Valve Prolapse and Sports Activity: Pathophysiology, Risk Stratification, and Sports Eligibility Assessment

  • Paolo Compagnucci,
  • Adelina Selimi,
  • Laura Cipolletta,
  • Giovanni Volpato,
  • Alessio Gasperetti,
  • Yari Valeri,
  • Quintino Parisi,
  • Antonio Curcio,
  • Andrea Natale and
  • Michela Casella
  • + 1 author

27 February 2024

Although mitral valve prolapse (MVP) is the most prevalent valvular abnormality in Western countries and generally carries a good prognosis, a small subset of patients is exposed to a significant risk of malignant ventricular arrhythmias (VAs) and su...

  • Article
  • Open Access
3 Citations
7,277 Views
14 Pages

Echocardiographic Parameters to Predict Malignant Events in Arrhythmic Mitral Valve Prolapse Population

  • Alessandro Vairo,
  • Paolo Desalvo,
  • Andrea Rinaudo,
  • Francesco Piroli,
  • Anna Tribuzio,
  • Andrea Ballatore,
  • Gianluca Marcelli,
  • Lorenzo Pistelli,
  • Veronica Dusi and
  • Carla Giustetto
  • + 8 authors

3 February 2023

Bileaflet Mitral Valve Prolapse (bMVP) has been linked to major arrhythmic events and sudden cardiac death (SCD). Consistent predictors in this field are still lacking. Echocardiography is the best tool for the analysis of the prolapse and its impact...

  • Interesting Images
  • Open Access
2,412 Views
4 Pages

Arrhythmic Mitral Valve Prolapse in the Young: A Rare but Concerning Entity

  • Nicolò Martini,
  • Alberto Cipriani,
  • Bortolo Martini,
  • Barbara Bauce,
  • Martina Perazzolo Marra,
  • Sabino Iliceto and
  • Domenico Corrado

Arrhythmic mitral valve prolapse (MVP) is an increasingly recognized clinical entity, characterized by the association of myxomatous mitral valve, ventricular arrhythmias (VAs) and sudden cardiac death (SCD). Prevalence of MVP is reported ranging bet...

  • Review
  • Open Access
24 Citations
8,994 Views
15 Pages

Mitral valve prolapse (MVP) is a common cause of valvular heart disease. Although many patients with MVP have a benign course, there is increasing recognition of an arrhythmic phenotype associated with ventricular arrhythmias and sudden cardiac death...

  • Review
  • Open Access
3 Citations
3,447 Views
13 Pages

Mitral valve prolapse (MVP) affects 2–3% of the general population, and despite its benign prognosis overall, it is associated with sudden death in a small subset of patients. The term “arrhythmic MVP syndrome” (AMVPS) refers to the...

  • Review
  • Open Access
44 Views
23 Pages

The Arrhythmogenic Spectrum of Mitral Valve Disease: Pathophysiology, Risk Stratification, and Surgical Management

  • Mariagrazia Piscione,
  • Barbara Pala,
  • Francesco Cribari,
  • Walter Vignaroli,
  • Jad Mroue,
  • Vivek Mehta,
  • Fadi Matar and
  • Marco Alfonso Perrone

21 January 2026

Mitral valve prolapse (MVP) is generally associated with excellent long-term outcomes when MR is absent or mild. Nonetheless, a small proportion of patients exhibit a distinct arrhythmogenic susceptibility, characterized by complex ventricular ectopy...

  • Case Report
  • Open Access
2 Citations
771 Views
13 Pages

Does Preliminary Chest Shape Assessment Improve the Prognostic Risk Stratification of Individuals with Mitral Annular Disjunction? A Case Report and Narrative Review

  • Andrea Sonaglioni,
  • Gian Luigi Nicolosi,
  • Giovanna Elsa Ute Muti-Schünemann,
  • Gaetana Anna Rispoli,
  • Michele Lombardo and
  • Paola Muti

26 March 2025

Background: Mitral annular disjunction (MAD), a mitral annular abnormality involving the whole mitral valve annulus circumference, commonly detected in individuals with mitral valve prolapse (MVP), has been recently recognized as a potential risk fac...

  • Systematic Review
  • Open Access
1,256 Views
19 Pages

22 October 2025

Background: Mitral valve prolapse (MVP) is the most common valvular abnormality in the general population and has been linked to mitral regurgitation, arrhythmias, and sudden cardiac death. Its prevalence and prognostic significance in athletes remai...

  • Review
  • Open Access
21 Citations
8,685 Views
15 Pages

Arrhythmic Mitral Valve Prolapse: Introducing an Era of Multimodality Imaging-Based Diagnosis and Risk Stratification

  • Deni Kukavica,
  • Marco Guglielmo,
  • Andrea Baggiano,
  • Giuseppe Muscogiuri,
  • Laura Fusini,
  • Manuela Muratori,
  • Gloria Tamborini,
  • Valentina Mantegazza,
  • Alessandro Trancuccio and
  • Gianluca Pontone
  • + 4 authors

Mitral valve prolapse is a common cardiac condition, with an estimated prevalence between 1% and 3%. Most patients have a benign course, but ever since its initial description mitral valve prolapse has been associated to sudden cardiac death. Althoug...

  • Case Report
  • Open Access
2 Citations
6,972 Views
6 Pages

Mitral valve prolapse (MVP) is a common valvular disease, which may remain a benign condition for a long period of time. However, some patients experience malignant ventricular arrhythmias and sudden cardiac death (SCD). It is still largely unknown h...

  • Review
  • Open Access
1 Citations
2,122 Views
16 Pages

Mitral Valve Prolapse and Sudden Cardiac Death—A Puzzle with Missing Pieces: Review of the Literature and Case Report

  • Diana Roxana Opris,
  • Marius Mihai Harpa,
  • David-Emanuel Anitei,
  • Paul Calburean and
  • Roxana Rudzik

10 September 2025

Background: Mitral valve prolapse is a common valvular heart disorder, usually associated with a benign prognosis in the absence of significant mitral regurgitation. However, a subset of patients is at increased risk for complex ventricular arrhythmi...

  • Case Report
  • Open Access
8 Citations
863 Views
2 Pages

20 April 2017

We describe the case of a 46-year old female with a Barlow’s disease (MVP) characterized by systolic curling of posterior left ventricular (LV) wall + significant mitral annular disjunction + complex ventricular arrhythmias + syncope + inverted T wav...

  • Review
  • Open Access
15 Citations
5,187 Views
10 Pages

Mitral valve prolapse (MVP) was first described in the 1960s, and it is usually a benign condition. However, a subtype of patients are known to have a higher incidence of ventricular arrhythmias and sudden cardiac death, the so called “arrhythmic MVP...

  • Article
  • Open Access
1,175 Views
13 Pages

Mitral Annular Disjunction and Arrhythmic Risk: Case Series and State of the Art

  • Marisa Varrenti,
  • Eleonora Bonvicini,
  • Leandro Fabrizio Milillo,
  • Ilaria Garofani,
  • Lorenzo Gigli,
  • Matteo Baroni,
  • Alberto Preda,
  • Marco Carbonaro,
  • Roberto Menè and
  • Patrizio Mazzone
  • + 8 authors

Background: Mitral annular disjunction (MAD) is an anatomical abnormality associated with an increased risk of major arrhythmic events, regardless of the presence of mitral valve prolapse. Cardiac magnetic resonance (CMR) plays a key role in diagnosi...

  • Review
  • Open Access
17 Citations
4,906 Views
18 Pages

26 February 2022

Sudden cardiac death (SCD) from ventricular fibrillation (VF) can occur in mitral valve prolapse (MVP) in the absence of other comorbidities including mitral regurgitation, heart failure or coronary disease. Although only a small proportion with MVP...

  • Article
  • Open Access
7 Citations
3,273 Views
18 Pages

Left Ventricle Segmental Longitudinal Strain and Regional Myocardial Work Index Could Help Determine Mitral Valve Prolapse Patients with Increased Risk of Ventricular Arrhythmias

  • Ludmiła Daniłowicz-Szymanowicz,
  • Agnieszka Zienciuk-Krajka,
  • Elżbieta Wabich,
  • Marcin Fijałkowski,
  • Jadwiga Fijałkowska,
  • Krzysztof Młodziński and
  • Grzegorz Raczak

Mitral valve prolapse (MVP) could associate with malignant ventricular arrhythmias (VAs). Mitral annular disjunction, a putative mechanism for an arrhythmic substrate, leads to excessive mobility, stretch, and damage of some segments. Speckle trackin...

  • Systematic Review
  • Open Access
5 Citations
2,638 Views
19 Pages

The Prevalence, Pathophysiological Role and Determinants of Mitral Annular Disjunction Among Patients with Mitral Valve Prolapse: A Systematic Review

  • Andrea Sonaglioni,
  • Gian Luigi Nicolosi,
  • Giovanna Elsa Ute Muti-Schünemann,
  • Michele Lombardo and
  • Paola Muti

20 February 2025

Background: Over the last two decades, a number of imaging studies have evaluated the characteristics and clinical implications of mitral annular disjunction (MAD) among patients with mitral valve prolapse (MVP). The present systematic review has bee...

  • Case Report
  • Open Access
4 Citations
3,828 Views
9 Pages

Autoimmune Myocarditis and Arrhythmogenic Mitral Valve Prolapse: An Unexpected Overlap Syndrome

  • Andrea Villatore,
  • Simone Sala,
  • Stefano Stella,
  • Davide Vignale,
  • Elena Busnardo,
  • Antonio Esposito,
  • Cristina Basso,
  • Paolo Della Bella,
  • Patrizio Mazzone and
  • Giovanni Peretto

Background: both myocarditis and mitral valve prolapse (MVP) are known uncommon causes of ventricular arrhythmias in young patients. Aim: to report the first clinical case of endomyocardial biopsy (EMB)-proven autoimmune myocarditis and associated ar...