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  • Article
  • Open Access
19 Citations
4,227 Views
12 Pages

29 December 2021

Strain NJES-13T is the type strain and currently the only species of the newly established actinobacteria genera Aptenodytes in the family Dermatophilaceae isolated from the gut microbiota of the Antarctic emperor penguin. This strain demonstrated ex...

  • Article
  • Open Access
6 Citations
5,450 Views
15 Pages

(-)-Shikimic Acid as a Chiral Building Block for the Synthesis of New Cytotoxic 6-Aza-Analogues of Angucyclinones

  • Natalia Quiñones,
  • Santiago Hernández,
  • Luis Espinoza Catalán,
  • Joan Villena,
  • Ivan Brito,
  • Alan R. Cabrera,
  • Cristian O. Salas and
  • Mauricio A. Cuellar

We describe the syntheses of nine new angucyclinone 6-aza-analogues, achieved through a hetero Diels-Alder reaction between the shikimic acid derivative-azadiene 13, with different naphthoquinones. The cytotoxic activity of the new synthesized compou...

(This article belongs to the Section Medicinal Chemistry)
  • Article
  • Open Access
32 Citations
8,775 Views
8 Pages

Kiamycin, a Unique Cytotoxic Angucyclinone Derivative from a Marine Streptomyces sp.

  • Zeping Xie,
  • Bing Liu,
  • Hongpeng Wang,
  • Shengxiang Yang,
  • Hongyu Zhang,
  • Yipeng Wang,
  • Naiyun Ji,
  • Song Qin and
  • Hartmut Laatsch

27 February 2012

Kiamycin (1), a new angucyclinone derivative possessing an 1,12-epoxybenz[a]anthracene ring system, was isolated from the marine Streptomyces sp. strain M268 along with the known compounds 8-O-methyltetrangomycin (3) and 8-O-methylrabelomycin (4). Th...

  • Article
  • Open Access
39 Citations
8,342 Views
19 Pages

Monacyclinones, New Angucyclinone Metabolites Isolated from Streptomyces sp. M7_15 Associated with the Puerto Rican Sponge Scopalina ruetzleri

  • Jan Vicente,
  • Allison K. Stewart,
  • Ryan M. Van Wagoner,
  • Elizabeth Elliott,
  • Andrea J. Bourdelais and
  • Jeffrey L. C. Wright

29 July 2015

During an investigation of new actinomycete species from Caribbean sponges for novel bioactive natural products, frigocyclinone (1), dimethyldehydrorabelomycin (3) and six new angucyclinone derivatives were isolated from Streptomyces sp. strain M7_15...

(This article belongs to the Special Issue Marine Secondary Metabolites)
  • Article
  • Open Access
23 Citations
5,010 Views
13 Pages

Donghaecyclinones A–C: New Cytotoxic Rearranged Angucyclinones from a Volcanic Island-Derived Marine Streptomyces sp.

  • Munhyung Bae,
  • Joon Soo An,
  • Seong-Heon Hong,
  • Eun Seo Bae,
  • Beomkoo Chung,
  • Yun Kwon,
  • Suckchang Hong,
  • Ki-Bong Oh,
  • Jongheon Shin and
  • Dong-Chan Oh
  • + 1 author

18 February 2020

Chemical profiling of the Streptomyces sp. strain SUD119, which was isolated from a marine sediment sample collected from a volcanic island in Korea, led to the discovery of three new metabolites: donghaecyclinones A–C (1–3). The structur...