Skip to Content
MDPIMDPI

4 Results Found

  • Feature Paper
  • Article
  • Open Access
4 Citations
4,203 Views
16 Pages
Download PDF

Bioinspired Honokiol Analogs and Their Evaluation for Activity on the Norepinephrine Transporter

  • Kristen Stout,
  • Marketa Bernaskova,
  • Gary W. Miller,
  • Antje Hufner and
  • Wolfgang Schuehly
Molecules2018, 23(10), 2536;https://doi.org/10.3390/molecules23102536

4 October 2018

In traditional Asian medicinal systems, preparations of the root and stem bark of Magnolia species are widely used to treat anxiety and other nervous disturbances. The biphenyl-type neolignans honokiol and magnolol are the main constituents of Magnol...

(This article belongs to the Special Issue Special Issue in Honor of Professor Nikolaus (Klaus) Fischer on the Occasion of His 80th Birthday)
Full Article
  • Article
  • Open Access
6 Citations
3,123 Views
11 Pages
Download PDF

Influence of the Molar Activity of 203/212Pb-PSC-PEG2-TOC on Somatostatin Receptor Type 2-Binding and Cell Uptake

  • Marc Pretze,
  • Enrico Michler,
  • Roswitha Runge,
  • Kerstin Wetzig,
  • Katja Tietze,
  • Florian Brandt,
  • Michael K. Schultz and
  • Jörg Kotzerke
Pharmaceuticals2023, 16(11), 1605;https://doi.org/10.3390/ph16111605

14 November 2023

(1) Background: In neuroendocrine tumors (NETs), somatostatin receptor subtype 2 is highly expressed, which can be targeted by a radioactive ligand such as [177Lu]Lu-1,4,7,10-tetraazacyclododecane-N,N′,N″,N‴,-tetraacetic acid-[Tyr3,...

(This article belongs to the Special Issue Therapeutic Radionuclides in Nuclear Medicine)
Full Article
  • Article
  • Open Access
9 Citations
4,156 Views
18 Pages
Download PDF

[111In]In/[177Lu]Lu-AAZTA5-LM4 SST2R-Antagonists in Cancer Theranostics: From Preclinical Testing to First Patient Results

  • Berthold A. Nock,
  • Panagiotis Kanellopoulos,
  • Euy Sung Moon,
  • Maritina Rouchota,
  • George Loudos,
  • Sanjana Ballal,
  • Madhav P. Yadav,
  • Chandrasekhar Bal,
  • Prashant Mishra and
  • Theodosia Maina
  • + 2 authors
Pharmaceutics2023, 15(3), 776;https://doi.org/10.3390/pharmaceutics15030776

26 February 2023

Aiming to expand the application of the SST2R-antagonist LM4 (DPhe-c[DCys-4Pal-DAph(Cbm)-Lys-Thr-Cys]-DTyr-NH2) beyond [68Ga]Ga-DATA5m-LM4 PET/CT (DATA5m, (6-pentanoic acid)-6-(amino)methy-1,4-diazepinetriacetate), we now introduce AAZTA5-LM4 (AAZTA5...

(This article belongs to the Special Issue Recent Advances in Radiopharmaceutics, 2nd Edition)
Full Article
  • Article
  • Open Access
15 Citations
6,581 Views
16 Pages
Download PDF

Interaction Profiles of Central Nervous System Active Drugs at Human Organic Cation Transporters 1–3 and Human Plasma Membrane Monoamine Transporter

  • Thomas J. F. Angenoorth,
  • Stevan Stankovic,
  • Marco Niello,
  • Marion Holy,
  • Simon D. Brandt,
  • Harald H. Sitte and
  • Julian Maier
Int. J. Mol. Sci.2021, 22(23), 12995;https://doi.org/10.3390/ijms222312995

30 November 2021

Many psychoactive compounds have been shown to primarily interact with high-affinity and low-capacity solute carrier 6 (SLC6) monoamine transporters for norepinephrine (NET; norepinephrine transporter), dopamine (DAT; dopamine transporter) and seroto...

(This article belongs to the Special Issue Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations 2.0)
Full Article