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4 Results Found

  • Article
  • Open Access
13 Citations
4,228 Views
16 Pages

ATRvD1 Attenuates Renal Tubulointerstitial Injury Induced by Albumin Overload in Sepsis-Surviving Mice

  • José Bruno N. F. Silva,
  • Thayanne B. B. Calcia,
  • Cyntia P. Silva,
  • Rafael F. Guilherme,
  • Fernando Almeida-Souza,
  • Felipe S. Lemos,
  • Kátia S. Calabrese,
  • Celso Caruso-Neves,
  • Josiane S. Neves and
  • Claudia F. Benjamim

27 October 2021

Novel strategies for the prevention and treatment of sepsis-associated acute kidney injury and its long-term outcomes have been required and remain a challenge in critical care medicine. Therapeutic strategies using lipid mediators, such as aspirin-t...

(This article belongs to the Special Issue Sepsis: From Molecular Mechanisms, Pathophysiology to Novel Therapeutic Approaches)
  • Article
  • Open Access
18 Citations
5,396 Views
21 Pages

Aspirin-Triggered Resolvin D1 (AT-RvD1) Protects Mouse Skin against UVB-Induced Inflammation and Oxidative Stress

  • Cristina P. B. Melo,
  • Priscila Saito,
  • Renata M. Martinez,
  • Larissa Staurengo-Ferrari,
  • Ingrid C. Pinto,
  • Camilla C. A. Rodrigues,
  • Stephanie Badaro-Garcia,
  • Josiane A. Vignoli,
  • Marcela M. Baracat and
  • Rubia Casagrande
  • + 3 authors

Intense exposure to UVB radiation incites excessive production of reactive oxygen species (ROS) and inflammation. The resolution of inflammation is an active process orchestrated by a family of lipid molecules that includes AT-RvD1, a specialized pro...

(This article belongs to the Section Bioactive Lipids)
  • Article
  • Open Access
19 Citations
4,659 Views
16 Pages

Aspirin-Triggered Resolvin D1 Reduces Proliferation and the Neutrophil to Lymphocyte Ratio in a Mutant KRAS-Driven Lung Adenocarcinoma Model

  • Amanda Vannitamby,
  • Mohamed I. Saad,
  • Christian Aloe,
  • Hao Wang,
  • Beena Kumar,
  • Ross Vlahos,
  • Stavros Selemidis,
  • Louis Irving,
  • Daniel Steinfort and
  • Steven Bozinovski
  • + 1 author

28 June 2021

Tumour-associated neutrophils (TANs) can support tumour growth by suppressing cytotoxic lymphocytes. AT-RvD1 is an eicosanoid that can antagonise neutrophil trafficking instigated by ALX/FPR2 ligands such as serum amyloid A (SAA). We aimed to establi...

(This article belongs to the Section Molecular Cancer Biology)
  • Article
  • Open Access
16 Citations
4,681 Views
25 Pages

Aspirin-Triggered Resolvin D1 Reduces Chronic Dust-Induced Lung Pathology without Altering Susceptibility to Dust-Enhanced Carcinogenesis

  • Edward C. Dominguez,
  • Rattapol Phandthong,
  • Matthew Nguyen,
  • Arzu Ulu,
  • Stephanie Guardado,
  • Stefanie Sveiven,
  • Prue Talbot and
  • Tara M. Nordgren

9 April 2022

Lung cancer is the leading cause of cancer-related deaths worldwide, with increased risk being associated with unresolved or chronic inflammation. Agricultural and livestock workers endure significant exposure to agricultural dusts on a routine basis...

(This article belongs to the Section Cancer Immunology and Immunotherapy)