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12 Pages

β-Ketophosphonates with Pentalenofuran Scaffolds Linked to the Ketone Group for the Synthesis of Prostaglandin Analogs

Constantin I. Tănase,
Constantin Drăghici,
Miron Teodor Căproiu,
Anamaria Hanganu and ,
Gheorghe Borodi,
Maria Maganu,
Emese Gal and
Lucia Pintilie
+ 3 authors+ 0 author

Int. J. Mol. Sci.2021, 22(13), 6787;https://doi.org/10.3390/ijms22136787

24 June 2021

β-Ketophosphonates with pentalenofurane fragments linked to the keto group were synthesized. The bulky pentalenofurane skeleton is expected to introduce more hindrance in the prostaglandin analogues of type III, greater than that obtained with the bi...

(This article belongs to the Section Bioactives and Nutraceuticals)

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4 Pages

Key Intermediates for Building the ω-Side Chain of Prostaglandins with a Constrained Pentalenofurane Scaffold Linked to C-15 Carbon Atom to Diminish the PG Inactivation

Constantin Tanase,
Constantin Draghici,
Miron Teodor Caproiu,
Anamaria Hanganu and ,
Gheorghe Borodi,
Maria Maganu,
Emese Gal and
Lucia Pintilie
+ 3 authors+ 0 author

Chem. Proc.2022, 7(1), 84;https://doi.org/10.3390/chemproc2022007084

30 June 2022

The inactivation of prostaglandin (PG) and prostaglandin analogs (PGs) is realized with enzyme oxidation of the 15α-OH to the 15-keto group via the 15-PGDH pathway [...]

(This article belongs to the Proceedings of The 17th International Symposium “Priorities of Chemistry for a Sustainable Development” PRIOCHEM)

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