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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Structure-Based Antiviral Drugs and Vaccine Design

edited by

Shi-hua Xiang

and

Fengwei Bai

submission deadline 15 Dec 2025 | 3 articles | Viewed by 5000 | Submission Open

Keywords: antiviral; structure based; AI-powered; drug design; vaccine design

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Diversity and Coinfections of Plant or Fungal Viruses, 3rd Edition

edited by

Islam Hamim

Ken Komatsu

and

Hiromitsu Moriyama

submission deadline 20 Dec 2025 | 4 articles | Viewed by 8220 | Submission Open

Keywords: diagnosis; surveillance; molecular mechanism; viroid; subviral agents; mycoviruses; biological control; pesticide resistance; antiviral defense mechanism; population genetics; recombination; gene expressions; host range

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Virology in Italy 2025—9th National Congress of the Italian Society for Virology

edited by

Enzo Tramontano

Arnaldo Caruso

Massimiliano Galdiero

Luisa Rubino

and

Gabriele Vaccari

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1237 | Submission Open

Keywords: Italy; emerging viruses; viral subversion of host cell processes; viruses of microbes; antivirals; vaccines; emerging methods in virology; RNA in virus infection; plant viruses; antiviral innate immunity; animal viruses; mycoviruses

(This special issue belongs to the Section General Virology)

RSV Epidemiological Surveillance: 2nd Edition

edited by Emanuele Castagno and Irene Raffaldi

submission deadline 30 Dec 2025 | 6 articles | Viewed by 12135 | Submission Open

Keywords: respiratory syncytial virus (RSV); epidemiological surveillance; bronchiolitis; children; newborns; infants

(This special issue belongs to the Section Human Virology and Viral Diseases)

Understanding the Oncogenesis of Human Herpesviruses through Their Critical Comparisons

edited by Ya-Fang Chiu and Bill Sugden

submission deadline 30 Dec 2025 | 3 articles | Viewed by 9886 | Submission Open

(This special issue belongs to the Section Human Virology and Viral Diseases)

HIV Reservoirs, Latency, and the Factors Responsible

edited by Yuyang Tang and

Mudit Tyagi

submission deadline 31 Dec 2025 | 6 articles | Viewed by 28194 | Submission Open

Keywords: HIV; HIV latency; HIV persistence; HIV eradication; HIV cure; HIV vaccine

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viral Infections and Immune Dysregulation 2024–2025

edited by

Ester Ballana Guix

and

Ifeanyi Jude Ezeonwumelu

submission deadline 31 Dec 2025 | 6 articles | Viewed by 24375 | Submission Open

Keywords: immune responses; immune dysregulation; autoimmunity; viral infections; immunomodulation

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Controlling Zoonotic Viral Diseases from One Health Perspective 2025

edited by

Maureen T. Long

and Erika Schwarz-Collins

submission deadline 31 Dec 2025 | 5 articles | Viewed by 21438 | Submission Open

Keywords: one health; viral zoonoses; control; vaccine; surveillance; epidemiology

(This special issue belongs to the Section Animal Viruses)

Microscopy Methods for Virus Research

edited by Krishanu Ray

submission deadline 31 Dec 2025 | 7 articles | Viewed by 21203 | Submission Open

Keywords: viruses; fluorescence imaging; single-molecule imaging; super-resolution imaging; intra-vital imaging; electron microscopy; Cryo-EM; Cryo-ET

(This special issue belongs to the Section General Virology)

SARS-CoV-2, COVID-19 Pathologies, Long COVID, and Anti-COVID Vaccines

edited by

Jean-Marc Sabatier

submission deadline 31 Dec 2025 | 7 articles | Viewed by 20219 | Submission Open

Keywords: SARS-CoV-2; COVID-19; long COVID; anti-COVID vaccines; spikeopathy; renin– angiotensin system

(This special issue belongs to the Section Coronaviruses)

EBV and Disease: New Perspectives in the Post COVID-19 Era

edited by

Xiaoming Lyu

and Dengke Li

submission deadline 31 Dec 2025 | 7 articles | Viewed by 19689 | Submission Open

Keywords: EBV; reactivation and immune dysregulation; EBV-associated malignancies; autoimmune diseases; diagnostic and therapeutic

(This special issue belongs to the Section Human Virology and Viral Diseases)

Host Cell-Virus Interaction, 4th Edition

edited by

Parikshit Bagchi

and

Anupam Mukherjee

submission deadline 31 Dec 2025 | 9 articles | Viewed by 16552 | Submission Open

Keywords: virus; viral proteins; virus entry; viral replication and pathogenesis; virus assembly and egress; intracellular trafficking of virus; host cell; cellular signaling; interferon pathway; inflammasome; viral immune evasion; immune response; cell death; apoptosis; autophagy; host-virus interaction; anti-viral strategies; direct acting antivirals; broad-spectrum antiviral agents; RNAi; microRNAs; neutralizing antibodies; molecular mechanisms of antivirals; molecular mechanisms of drug-resistance

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Preparation for the Next Potential Pandemic—Chikungunya, Dengue, Zika and Other Viruses

edited by

Zoltan Vajo

submission deadline 31 Dec 2025 | 7 articles | Viewed by 16188 | Submission Open

Keywords: chikungunya; dengue; zika; next pandemic; epidemiology; pharmaceutics; immunology

(This special issue belongs to the Section Human Virology and Viral Diseases)

Natural, Semisynthetic, and Synthetic Antiviral Drugs Targeting HIV and SARS-CoV-2

edited by

Otávio Augusto Chaves

and

Carlos Serpa

submission deadline 31 Dec 2025 | 6 articles | Viewed by 14422 | Submission Open

Keywords: antiviral design and discovery; natural product screening; natural products as a scaffold for semisynthetic antivirals; repurposing drugs; high-throughput screening; antiviral resistance; biophysical characterization of the interaction between antivirals and targets; combination of light and photosensitizers in antiviral discovery; cell-based and in vivo assays; in silico calculations

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

H5N1 Influenza Viruses

edited by

Daniel R. Perez

submission deadline 31 Dec 2025 | 6 articles | Viewed by 12973 | Submission Open

Keywords: H5N1; avian influenza; genetic diversity; immune response; vaccines and antiviral therapies

(This special issue belongs to the Section Animal Viruses)

Molecular Biomarkers for Viral Infection

edited by

Paulina Niedźwiedzka-Rystwej

submission deadline 31 Dec 2025 | 4 articles | Viewed by 10850 | Submission Open

Keywords: molecular biomarkers; viral infections

(This special issue belongs to the Section Animal Viruses)

Application of Genetically Engineered Plant Viruses

edited by

Tsung-Chi Chen

submission deadline 31 Dec 2025 | 4 articles | Viewed by 9396 | Submission Open

Keywords: plant virus; infectious clone; viral vector; virus-induced gene silencing (VIGS); virus-like particles (VLPs); cross-protection

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Advancing Hepatitis Elimination: HBV, HDV, and HCV

edited by

Federico García

submission deadline 31 Dec 2025 | 6 articles | Viewed by 7634 | Submission Open

Keywords: hepatitis elimination; HBV; HCV; HDV

(This special issue belongs to the Section Human Virology and Viral Diseases)

Lung Immunity to Viral Infections

edited by

Ana Paula Duarte De Souza

submission deadline 31 Dec 2025 | 3 articles | Viewed by 7492 | Submission Open

Keywords: respiratory virus; lung immune response; vaccines to respiratory virus; microbiota and lung immune response; environmental factors and lung immune responses; virus– host interaction in the lung; immunotherapies to prevent or treat respiratory viral infection

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Porcine Viruses 2025

edited by

Guoxin Li

Lingxue Yu

and

Jin Cui

submission deadline 31 Dec 2025 | 8 articles | Viewed by 7007 | Submission Open

Keywords: epidemiology; pathogenesis; immune evasion; virus evolution; vaccine

(This special issue belongs to the Section Animal Viruses)

Interplay Between Influenza Virus and Host Factors

edited by

Matloob Husain

submission deadline 31 Dec 2025 | 4 articles | Viewed by 6902 | Submission Open

Keywords: influenza virus; host factors; proviral host factors; antiviral host factors; host adaptation; virus entry; virus assembly; virus release; innate antiviral response; interferon-stimulated genes; post-translational protein modifications

(This special issue belongs to the Section Animal Viruses)

Severe Fever with Thrombocytopenia Syndrome Virus 2025

edited by

Masayuki Saijo

submission deadline 31 Dec 2025 | 4 articles | Viewed by 6378 | Submission Open

Keywords: SFTS; SFTSV; emerging viral infections

(This special issue belongs to the Section Human Virology and Viral Diseases)

Emerging Microbes, Infections and Spillovers, 2nd Edition

edited by

Ravi Kant

Tarja Sironen

and

Maciej Grzybek

submission deadline 31 Dec 2025 | 4 articles | Viewed by 6042 | Submission Open

Keywords: emerging infections; virus spillovers; microbes; cross-species transmission; virus evolution; viral disease; virus reservoirs; virus– host interaction; pathogenesis

(This special issue belongs to the Section Animal Viruses)

Viral Strategies and Cellular Countermeasures That Regulate mRNA Access to the Translation Apparatus: 2nd Edition

edited by

Christopher U. T. Hellen

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5311 | Submission Open

Keywords: virus– host interactions; IRES elements; RNA structure; translation initiation; translational control; innate immune response; RNA modification

(This special issue belongs to the Section General Virology)

Viral Diseases of Sheep and Goats

edited by Ramsés Reina and Álex Gómez

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5047 | Submission Open

Keywords: small ruminants; viral immunopathogenesis; infection; transmission; epidemiology; control strategies; vaccines

(This special issue belongs to the Section Animal Viruses)

Molecular Virus–Insect Interactions, 2nd Edition

edited by Li-Long Pan

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4816 | Submission Open

Keywords: plant virus-insect vector interactions; virus transmission; entomopathogenic virus-insect host interactions; insect-specific viruses; induction and suppression of immune responses

(This special issue belongs to the Section Invertebrate Viruses)

Animal Virus Discovery and Genetic Diversity: 2nd Edition

edited by

Ryan Troyer

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3837 | Submission Open

Keywords: animal virus; evolution; genetic; diversity; richness; emerging viruses; virome; metagenomics; ecology; cross-species transmission; zoonotic

(This special issue belongs to the Section Animal Viruses)

Antiviral Development for Emerging and Re-Emerging Viruses

edited by

Ming-Hon Hou

and

Shih-Chao Lin

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3791 | Submission Open

Keywords: protein– protein interaction; viral– host interaction; viral replication; antiviral; human viruses; emerging infections

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Oncogenic Infections and Cancer: Clinical Insights and Emerging Therapeutics

edited by G. Hossein Ashrafi and Mustafa Ozdogan

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3367 | Submission Open

Keywords: oncogenesis; viral oncology; bacterial oncogenesis; human papillomavirus (HPV); Epstein– Barr virus (EBV); Kaposi’ s sarcoma-associated herpesvirus (KSHV); hepatitis B virus (HBV); hepatitis C virus (HCV); human T-lymphotropic virus (HTLV-1); Helicobacter pylori; infection-driven cancers; molecular mechanisms; tumor microenvironment; immunotherapy; viral persistence; antiviral therapies; CRISPR-based treatments; cancer prevention; vaccine development; immune checkpoint inhibitors; diagnostic biomarkers; personalized medicine; translational oncology; therapeutic resistance; emerging therapeutics

(This special issue belongs to the Section Human Virology and Viral Diseases)

Coronavirus Pathogenesis and Virus-Host Interaction

edited by

Hin Chu

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3059 | Submission Open

Keywords: COVID-19; SARS-CoV-2; SARS-CoV-1; MERS-CoV; pathogenesis; virus– host interaction; virus entry; host factors; animal models; SARS-CoV-2 variants

(This special issue belongs to the Section General Virology)

Human Hepatitis Viruses and Their Animal Homologues

edited by

Bo Wang

and

Xinglou Yang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2988 | Submission Open

Keywords: hepatitis viruses; animal virome; genetic diversity; genomic organization; ecology and evolution; molecular biology; molecular epidemiology; zoonotic potential

(This special issue belongs to the Section General Virology)

Virological and Immunological Factors Underlying HBV Functional Cure and HBV Reactivation

edited by

Valentina Svicher

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2558 | Submission Open

Keywords: HBV persistence; HBV functional cure; cccDNA; immunology of HBV; HBV reactivation; immune-escape mutations

(This special issue belongs to the Section Human Virology and Viral Diseases)

Picornavirus Evolution, Host Adaptation and Antiviral Strategies

edited by

Leyi Wang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2527 | Submission Open

Keywords: virus evolution; new picornavirus; variant picornavirus; host adaptation; vaccine immunization; antiviral drugs

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Zika Virus and Congenital Zika Syndrome, 2nd Edition

edited by Marcos Vinicius da Silva Pone and Sheila Moura Pone

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2488 | Submission Open

Keywords: viral infections; Zika virus; congenital Zika syndrome

(This special issue belongs to the Section Human Virology and Viral Diseases)

Early Diagnosis and Surveillance of Transboundary and Emerging Viral Diseases of Animals, 2nd Edition

edited by

Aruna Ambagala

and

Kalhari Goonewardene

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2388 | Submission Open

Keywords: diagnostics; surveillance; transboundary; emerging; animal diseases; virus; detection; validation; novel; sample types; alternative

(This special issue belongs to the Section Animal Viruses)

Harnessing AI and Machine Learning for Antiviral Development

edited by

X. Frank Zhang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2120 | Submission Open

Keywords: artificial intelligence; machine learning; antiviral therapies; personalized medicine; drug discovery; drug repurposing; drug resistance

(This special issue belongs to the Section General Virology)

Viral Immunology in Transplant Patients

edited by

Alessandro Perrella

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2020 | Submission Open

Keywords: viral infections; transplant patients; immunocompromised; immune response; host– pathogen interactions; immunotherapies; diagnostic approaches; preventive strategies

(This special issue belongs to the Section Human Virology and Viral Diseases)

Virology and Immunology of Gene Therapy 2026

edited by Weidong Xiao and

Jianming Qiu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2004 | Submission Open

Keywords: gene therapy; viral vector; vaccine; immune responses; viruses; AAV; lentiviral vectors; neutralizing antibody

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Cyanophage and Algal Virus

edited by

Rodrigo Araújo Lima Rodrigues

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1702 | Submission Open

Keywords: cyanophages; algal viruses; Algavirales; Phycodnaviridae; Marnaviridae; aquatic virus; algae bloom; viral diversity; viral ecology

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Arboviruses and Climate, 2nd Edition

edited by José Lourenço and

Marta Giovanetti

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1420 | Submission Open

Keywords: arbovirus; climate; climate change; arthropods; vectors; epidemiology; evolution; ecology; public health

(This special issue belongs to the Section Invertebrate Viruses)

Virus Biosensing

edited by Guobin Mao

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1291 | Submission Open

Keywords: virus detection; molecular diagnosis; immunoassay; nucleic acid amplification; CRISPR-based detection; nucleic acid assembly; biosensor; point-of-care testing

(This special issue belongs to the Section General Virology)

The Structure and Function of Flavivirus Genes and Proteins

edited by

Tadahisa Teramoto

and Kay Choi

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1280 | Submission Open

Keywords: flavivirus; structural protein; non-structural protein; 5'UTR; 3'UTR

(This special issue belongs to the Section General Virology)

Phage Display in Cancer Diagnosis and Screening

edited by

Valery A. Petrenko

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1092 | Submission Open

Keywords: phage display; cancer; diagnosis; screening; prognosis and monitoring

(This special issue belongs to the Section Bacterial Viruses)

Antigenic Drift in Respiratory Viruses

edited by

Gabriel Gonzalez

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1016 | Submission Open

Keywords: respiratory viruses; virus diversity; viral recombination; reassortment; zoonotic viruses; wastewater pathogen surveillance; viral sequencing; virus evolutionary characterization; animal viruses

(This special issue belongs to the Section Human Virology and Viral Diseases)

Spotlight on Bocavirus and Other Parvoviruses, and Overlooked Respiratory Viruses

edited by

Suncanica Ljubin‐Sternak

and

Tatjana Vilibic-Cavlek

submission deadline 31 Dec 2025 | 1 articles | Viewed by 921 | Submission Open

Keywords: bocavirus; Parvovirus B19; canine parvovirus; porcine parvovirus; metapneumovirus; rhinovirus Planned Papers 1. Molecular detection of Porcine cytomegalovirus (PCMV) and Porcine parvovirus (PPV) in domestic pigs and wild boars from Croatia 2. Protoparvovirus carnivoran 1 outbreak in golden jackals in Croatia 3. Epidemiology of parvovirus B19 in Croatian childbearing-aged women: A ten-year seroprevalence study

(This special issue belongs to the Section Animal Viruses)

Advancing Research of Anelloviruses, Second Edition

edited by

Fabrizio Maggi

and

Pietro Giorgio Spezia

submission deadline 31 Dec 2025 | Viewed by 515 | Submission Open

Keywords: TTV; TTMV; TTMDV; virome; viral species; immune system; orphan virus

(This special issue belongs to the Section Human Virology and Viral Diseases)

Tackling Viral Resistance—Advances in Mechanisms, Detection, and Control

edited by

Nuno Taveira

and Claudia Palladino

submission deadline 31 Dec 2025 | Viewed by 345 | Submission Open

Keywords: viral resistance; antiviral therapies; drug resistance mechanisms; epidemiology; diagnostic advancements; clinical management

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Modeling Zoonotic and Vector-Borne Viruses in Evolving Ecological Systems

edited by

Salihu S. Musa

, Sani Isah Abba and Ismail Abdulrashid

submission deadline 31 Dec 2025 | Viewed by 327 | Submission Open

Keywords: zoonotic viruses; vector-borne diseases; climate change and disease dynamics; epidemiological modeling; outbreak forecasting and control; human behavior; virus– host– vector interactions

(This special issue belongs to the Section Animal Viruses)

Experimental Animal and Organoid-Based Lethal Virus Infection Models for Human, Companion Animals and Livestock

edited by

Tomomi Takano

submission deadline 31 Dec 2025 | Viewed by 280 | Submission Open

Keywords: organoid models; experimental animals; lethal virus infections; pathogenesis; vaccine development; therapeutic drugs; in vitro models; in vivo models; human viral infections; companion animal viral infections; livestock viral infections; viral infection models; ferret; hamster; transgenic mouse

(This special issue belongs to the Section General Virology)

Virus Infection Fate Regulation

edited by Andreas Meyerhans and

Gennady Bocharov

submission deadline 31 Dec 2025 | Viewed by 200 | Submission Open

Keywords: virus infection fate; dynamics; immune response; cellular response; regulation

(This special issue belongs to the Section General Virology)

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