Special Issue "Viruses and Exosomes"
Deadline for manuscript submissions: closed (15 April 2015).
Interests: cell entry, innate immune recognition and evolution of enveloped RNA viruses
Interests: molecular mechanisms of membrane trafficking and viral infection
Recent studies have identified intracellular vesicles as key components in viral pathogenesis. Among the wide variety of specialized lipid structures within endosomes, the intraluminal vesicles formed in early endosomes are emerging as critical effectors of viral infection and immune recognition. Certain viruses deliver their genomes into intraluminal vesicles, which then serve as vehicles to transport the genome along the endocytic pathway to the nuclear periphery for replication. Moreover, endosomal vesicles can be diverted to the exocytic pathway and secreted as exosomes. Exosomes containing viral genomes can promote viral spread by infecting adjacent, or in some cases distant permissive cells, while evading immune recognition, thanks to the absence of viral glycoproteins on the exosome membrane. Conversely, exosomes containing viral proteins or nucleic acids have been found to activate immune responses in myeloid cells in certain cases. Antigen-loaded dendritic cells can activate T cells by directly transferring exosomes to an interacting T cell, although some viruses, like HIV, have evolved to utilize DC to T-cell vesicle transfer as a route for productive infection. The collection of reviews and original research papers in this special issue is intended to summarize and highlight current research on the role of intracellular membrane trafficking and in particular of intracellular and secreted cellular vesicles in cell-to-cell transmission, immune sensing and immune evasion of viral pathogens. The implications of these new perspectives for the design of antiviral vaccines and therapeutics will also be addressed.
Dr. Yorgo Modis
Dr. Stephen Graham
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- virus cell entry
- virus egress
- membrane trafficking
- exosome, exocytosis
- exocytic vesicle
- intracellular compartment
- virus spread
- cell-to-cell transmission
- immune evasion.