Special Issue "Viruses and Extracellular Vesicles"
Deadline for manuscript submissions: closed (30 April 2020).
Interests: HIV; extracellular vesicles; cancer; restriction factors
Extracellular vesicles (EVs) is a generic name that describes a heterogeneous collection of membranous vesicles, which includes ectosomes, exosomes, microvesicles, microparticles, oncosomes, and prostasomes, which are released by almost all cell types. Contrary to the previously thought role for EVs―a mechanism to discard non-functional cellular components, various studies have shown that EVs are vehicles through which biologically active molecules can be disseminated to local or distal sites to mediate specific biological roles.
Given the diversity and complexity of EV biogenesis and cargo, it is no secret that EVs and viruses, especially enveloped RNA viruses, have much more in common than previously appreciated. For example, EVs and some viruses are similar in size and have a similar biogenesis. Moreover, EVs from virus-infected cells incorporate both host- and virus-encoded molecules. Thus, with the increase in EV diversity, interest in EV function, EV utility, and their role in physiological and pathophysiological processes has increased. However, the differing features of EVs and viruses, and identifying characteristics dependent on originating cell types, remain largely unknown.
In this Special Issue of Viruses, we want to highlight findings from cutting edge research on the interaction of EVs and viruses from the divergent body of professionals involved in EV/virology research. Of particular interest are studies on the interaction of EVs and viruses in plants, animals, or human hosts. We also invite manuscripts that discus viruses that are likely to respond to EV-based therapy. In addition, this Special Issue focuses on recent findings, knowledge gaps, and perspectives on the following:
- The biological implications of the broad EV size diversity and how to distinguish EVs from viral particles;
- The role of EV and virus biogenesis pathway in their composition and contribution to biology;
- Clinical and translational studies that characterize EV subpopulations and phenotypes under physiological or pathophysiological conditions;
- Studies on the compositional properties of EVs released by healthy and virally infected cells, carrying virally encoded molecules or viral particles;
- Studies focusing on separating infectious viruses (HIV and other small RNA viruses) from noninfectious EVs carrying viral products (proteins and nucleic acids);
- Studies that focus on how noninfectious EVs positively or negatively regulate viral infection;
- Studies that manipulate EVs as a means to inhibit viral infection;
- Implementation studies focused on applying EVs in therapeutics development.
Dr. Chioma M. Okeoma
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Extracellular vesicles