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Veterinary Sciences
Special Issues
Prevention and Control of Swine Infectious Diseases: 2nd Edition
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Prevention and Control of Swine Infectious Diseases: 2nd Edition

A special issue of Veterinary Sciences (ISSN 2306-7381). This special issue belongs to the section "Veterinary Microbiology, Parasitology and Immunology".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 1253

Special Issue Editors

Prof. Dr. Yafeng Qiu

E-Mail Website
Guest Editor
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai 200241, China
Interests: host–pathogen interactions; pulmonary infectious diseases; neurological infectious diseases; bacterial genomics and evolution; immune response; myeloid cells; T cells
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Bin Zhou

E-Mail Website
Guest Editor
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China
Interests: viral diseases in swine; vaccine; antiviral response; diagnostic assay; virus infection; virus endocytosis and replication; innate immunity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Disease, especially infectious disease, is one of the determinants of stability of swine production worldwide. Although a number of strategies have been developed for the prevention and control of swine infectious diseases, they are not yet enough for the complex situations that include a variety of pathogens, different virulence strains for one pathogen, different serotype strains for one pathogen, and so on. Epidemiological studies have provided novel information about infectious disease characteristics. Progress in regard to detection methods has benefited clinical studies of swine. Furthermore, progress in vaccine development has seen an improvement, according to epidemiological data.

This Special Issue of Veterinary Sciences welcomes original research and review articles, aiming to provide an overview of advances in the prevention and control of infectious swine diseases. In this Special Issue, research will focus on epidemiological studies in swine farms, progress in regard to the detection methods for different swine pathogens, and progress in vaccine development. Genomic analyses of different pathogens, characteristic of novel antigens, as well as the effects of novel adjuvants, will also be included in this Special Issue. Additionally, other research areas related to the prevention and control of swine disease are welcome.

We look forward to receiving your contributions.

Prof. Dr. Yafeng Qiu
Prof. Dr. Bin Zhou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • epidemiological investigations
  • detection methods
  • vaccine development
  • infectious diseases
  • genomic analysis
  • antigens
  • adjuvants
  • immune protection

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Published Papers (2 papers)

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Research

13 pages, 1992 KB  
Article
Development and Standardization of Indirect ELISA for African Swine Fever Virus Using Recombinant p30 Protein Produced in Prokaryotic System
by José Luis Cerriteño-Sánchez, José Bryan García-Cambrón, Perla Lucero Zavala-Ocampo, Llilianne Ganges and Julieta Sandra Cuevas-Romero
Vet. Sci. 2025, 12(10), 995; https://doi.org/10.3390/vetsci12100995 - 15 Oct 2025
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Abstract
African Swine Fever (ASF), caused by the African Swine Fever Virus (ASFV), is a highly contagious hemorrhagic disease with high mortality (≈100%) in pigs and is considered the most devastating disease to date. Given the importance of this disease, we aimed to assess [...] Read more.
African Swine Fever (ASF), caused by the African Swine Fever Virus (ASFV), is a highly contagious hemorrhagic disease with high mortality (≈100%) in pigs and is considered the most devastating disease to date. Given the importance of this disease, we aimed to assess the use of the recombinant p30 protein as the sole antigen for the development of an accurate and precise ELISA test (iELISA) for the virus. The recombinant p30 protein (rp30) was produced in a bacterial expression system using a SUMO-tagged expression vector. Protein expression was confirmed by Western blot analysis and purified using affinity chromatography. Antigenicity was evaluated in CF-1 mice, which demonstrated the ability to generate high levels of specific antibodies. The rp30 showed a sensitivity of 95.6% when used in the development of iELISA, a specificity of 92.3%, and a kappa index (κ) of 0.836. Furthermore, reference sera (OIE-ASF) were used to validate the assays, and the results demonstrated an excellent capacity to detect ASF antibodies using only the rp30 antigen up to a serum dilution of 1:100. The inter- and intra-assay variability coefficients were 4.27% and 4.85%, respectively, demonstrating that the assay was accurate and reproducible, allowing its use in seroepidemiological analyses for ASF surveillance. Full article
(This article belongs to the Special Issue Prevention and Control of Swine Infectious Diseases: 2nd Edition)
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10 pages, 1139 KB  
Article
Efficacy of PCV2 Vaccination Under Natural Conditions: A Longitudinal Study Using PCR and Virus Isolation
by Eugene Mazimpaka, Rissar Siringo Ringo, Tasuku Hirooka and Tamaki Okabayashi
Vet. Sci. 2025, 12(6), 575; https://doi.org/10.3390/vetsci12060575 - 11 Jun 2025
Viewed by 866
Abstract
Porcine circovirus type 2 (PCV2) is the main cause of porcine circovirus-associated disease (PCVAD). Despite the widespread use of anti-PCV2 vaccines, their efficacy varies, influenced by co-infection and evaluation methods. This study assessed the efficacy of Ingelvac CircoFLEX® PCV2 vaccine under natural [...] Read more.
Porcine circovirus type 2 (PCV2) is the main cause of porcine circovirus-associated disease (PCVAD). Despite the widespread use of anti-PCV2 vaccines, their efficacy varies, influenced by co-infection and evaluation methods. This study assessed the efficacy of Ingelvac CircoFLEX® PCV2 vaccine under natural conditions. One hundred serum samples were collected from vaccinated and non-vaccinated piglets aged 21 to 173 days. PCR and antibody positivity rates did not show significant differences between the two groups, but PCV2 gene load at 91 days was significantly lower (p = 0.0095) in the vaccinated group. Anti-PCV2 antibody titers were also significantly lower in the vaccinated group at 91, 145, and 173 days (p < 0.0001). PCV2 was isolated from 50% of piglets in the non-vaccinated group (50%), compared with none (0%) in the vaccinated group, suggesting that PCV2 gene load in the non-vaccinated group did not correlate with viremia. Both groups were positive for antibodies to porcine reproductive and respiratory syndrome virus (PRRSV) at 63 days, prior to the surge in PCV2 gene load, suggesting PRRSV may enhance PCV2 replication. These findings highlight that while the vaccine reduced PCVAD damage, evaluation should incorporate methods such as virus isolation instead of relying solely on PCR. Full article
(This article belongs to the Special Issue Prevention and Control of Swine Infectious Diseases: 2nd Edition)
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