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Toxics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Toxicity and Safety Assessment of Exposure to Heavy Metals

edited by

Cristina Carvalho

and

Michael Aschner

submission deadline 14 Nov 2025 | 4 articles | Viewed by 5702 | Submission Open

Keywords: human exposure to metals; environmental contamination; metals’ biogeochemistry; food metal contaminants; toxic effects of metals; metals’ mechanisms of toxicity; risk assessment; biomarkers; metallodrugs; metal ion chelators

(This special issue belongs to the Section Metals and Radioactive Substances)

From Low-Tier to Individual Effects of Emerging Pollutants: Integrative Approaches to Ecotoxicological Assessments—2nd Edition

edited by

Tiago Simoes

Hugo Monteiro

and

Nuno Ferreira

submission deadline 15 Nov 2025 | 2 articles | Viewed by 2099 | Submission Open

Keywords: biomarkers; ecotoxicology; emerging pollutants; biological effects; mode of action; integrative analysis; analytical methods; sub-lethal endpoints

(This special issue belongs to the Section Ecotoxicology)

Emerging Pollutants in the Air and Health Risks

edited by

Qi Zhao

and

Gongbo Chen

submission deadline 20 Nov 2025 | 5 articles | Viewed by 9566 | Submission Open

Keywords: emerging pollutants; air pollution; exposure assessment; risk assessment; novel methodologies; statistical modeling; toxic mechanisms

(This special issue belongs to the Section Exposome Analysis and Risk Assessment)

Toxicity Assessment and Safety Management of Nanomaterials

edited by

Guotao Peng

submission deadline 20 Nov 2025 | 4 articles | Viewed by 4508 | Submission Open

Keywords: nanotoxicology; engineered nanomaterials; micro- and nanoplastics; nano– bio interactions; biotransformation; structure– activity relationship; health risks

(This special issue belongs to the Section Emerging Contaminants)

Plant Responses to Heavy Metal

edited by Yanqun Zu

submission deadline 20 Nov 2025 | 2 articles | Viewed by 1484 | Submission Open

Keywords: heavy metals; plant; soil pollution; phytoremediation; mechanism; regulation and control

New Insights into the Environmental Behaviour and Toxicity of Critical and Strategic Metals in Aquatic Ecosystems

edited by

Maikel Rosabal

, Séverine Le Faucheur and

Xu Yang

submission deadline 20 Nov 2025 | Viewed by 224 | Submission Open

Keywords: critical and strategic minerals (CSMs); environmental behavior; toxicological risk assessment; bioavailability and bioaccumulation; aquatic ecosystems; omics techniques

(This special issue belongs to the Section Metals and Radioactive Substances)

Emission and Exposure Assessment of Volatile Organic Compounds

edited by

Besis Athanasios

and

Dimitris Margaritis

submission deadline 20 Nov 2025 | Viewed by 218 | Submission Open

Keywords: volatile organic compounds (VOCs); secondary organic aerosols (SOAs); emission sources; monitoring techniques; exposure assessment; human health risk; VOC mitigation strategies; indoor and outdoor air quality; air pollution

(This special issue belongs to the Section Air Pollution and Health)

Exposure, Pathways and Assessment of (Eco)Toxicity of Nanomaterials

edited by

Gang Liang

submission deadline 20 Nov 2025 | Viewed by 167 | Submission Open

Keywords: toxicity; risk assessment; ecotoxicological effect; analytical methods; emerging nanomaterials

(This special issue belongs to the Section Ecotoxicology)

Multi-Media Environmental Pollution and Health Risks: Tracing, Effects, and Collaborative Governance

edited by

Dexin Liu

Jianbiao Peng

and Lihong Ren

submission deadline 21 Nov 2025 | 5 articles | Viewed by 3435 | Submission Open

Keywords: atmosphere; water; soil; sediment; pollutants; source apportionment; risk assessment; human exposure; pollution control; environmental pollution; health risks; heavy metal; environmental toxicology; ecotoxicology

(This special issue belongs to the Section Toxicity Reduction and Environmental Remediation)

New Approach Methodologies in Environmental Risk Assessment of Chemical Contaminants

edited by

Carlos Barata

submission deadline 21 Nov 2025 | Viewed by 218 | Submission Open

Keywords: approaches for pollution assessment; ecotoxicology; ecological effects; new approach methodologies; chemical toxicity; chemical contaminants; risk assessment

(This special issue belongs to the Section Ecotoxicology)

Neuronal Injury and Disease Induced by Environmental Toxicants

edited by

Jun Wang

and

Guixiang Ji

submission deadline 25 Nov 2025 | 6 articles | Viewed by 10004 | Submission Open

Keywords: neurotoxicology; neural injury and mechanisms; chemical exposure; neurodegenerative diseases; psychiatric disorders; toxicomics; toxic intervention

(This special issue belongs to the Section Neurotoxicity)

State-of-the-Art Environmental Chemical Exposomics and Metabolomics—2nd Edition

edited by

Minjian Chen

submission deadline 25 Nov 2025 | 5 articles | Viewed by 8624 | Submission Open

Keywords: exposomics; metabolomics; exposome; exposure; metabolome; metabolism; health; toxicity

(This special issue belongs to the Section Exposome Analysis and Risk Assessment)

Emissions, Environmental Behavior, Pollution Distribution, Modeling, and Risk Assessment of Persistent Organic Pollutants (POPs)

edited by Ye Huang

submission deadline 25 Nov 2025 | 2 articles | Viewed by 6993 | Submission Open

Keywords: persistent organic pollutants (POPs); emission inventory; environmental behavior; pollution distribution; risk assessment; modeling techniques; remediation strategies

(This special issue belongs to the Section Emerging Contaminants)

Airway Exposure to Pollution from Ambient Particulate Matter (PM) and Health Effects

edited by

Gloria Melzi

and

Yuewei Liu

submission deadline 28 Nov 2025 | 4 articles | Viewed by 3462 | Submission Open

Keywords: air pollution; particulate matter (PM); respiratory health; airway inflammation; oxidative stress; in vitro toxicology; alternative testing methods; cell culture models; health risk assessment

(This special issue belongs to the Section Air Pollution and Health)

Health Risk Assessment for Food Contaminants: Exposure and Human Toxicology

edited by

Yu-Syuan Luo

and

Nan-Hung Hsieh

submission deadline 28 Nov 2025 | Viewed by 146 | Submission Open

Keywords: food contaminants; health risk assessment; exposure modeling; toxicology; new approach methodologies (NAMs)

(This special issue belongs to the Section Exposome Analysis and Risk Assessment)

Biological Risk Monitoring of Exposure to Chemical Pollutants and/or Physical Agents: 2nd Edition

edited by

Mirta Milić

and

Nursen Basaran

submission deadline 29 Nov 2025 | 2 articles | Viewed by 3440 | Submission Open

Keywords: biomarkers of effect; biomarkers of exposure; biomarkers of susceptibility; DNA damage and repair; meta-analysis; biomonitoring; exposure; toxicokinetics and modes of action; risk assessment; epidemiology

(This special issue belongs to the Section Exposome Analysis and Risk Assessment)

Concentration of VOCs in the Atmosphere and Its Environmental Exposure

edited by

Xinlei Ge

and

Ming Wang

submission deadline 30 Nov 2025 | 4 articles | Viewed by 4334 | Submission Open

Keywords: VOCs; health risk assessment; exposure assessment; source identification; environmental impact

(This special issue belongs to the Section Emerging Contaminants)

Identification of Emerging Pollutants and Human Exposure

edited by

Xiaotu Liu

and

Ting Wu

submission deadline 30 Nov 2025 | 3 articles | Viewed by 4251 | Submission Open

Keywords: emerging contaminants; remediation strategies; non-targeted analysis; biomonitoring; exposome; risk assessment

Hazardous Pollutants in Marine Ecosystems

edited by

Maria Luisa Vannuccini

and Inmaculada Varó

submission deadline 30 Nov 2025 | 1 articles | Viewed by 2503 | Submission Open

Keywords: ecotoxicology; nanomaterials; bioaccumulation; biotransformation; biomonitoring; POPs; PAHs

Biological Effects and Mechanisms of Environmental Endocrine Disruptors

edited by Liting Zhou

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1068 | Submission Open

Keywords: environmental endocrine disruptors; epidemiological research; health effects; mixed exposure; emerging experimental models; mechanism

(This special issue belongs to the Section Human Toxicology and Epidemiology)

Fish Physiological Responses to Environmental Stressors

edited by

Jun Wang

submission deadline 30 Nov 2025 | 1 articles | Viewed by 774 | Submission Open

Keywords: fish ecotoxicology; physiological disruption; oxidative stress biomarkers; ecological risk assessment; bioaccumulation dynamics; endocrine disruption; population changes

(This special issue belongs to the Section Ecotoxicology)

Emerging Pollutants in the Aquatic Ecosystems: Occurrence, Fate and Effects on the Dissemination of Antibiotic Resistance Genes

edited by Lijun Zhou and Liangying He

submission deadline 30 Nov 2025 | Viewed by 296 | Submission Open

Keywords: antibiotics; antibiotic resistance genes; emerging pollutant; PPCPs; biocides; occurrence; ecological risk; horizontal gene transfer

(This special issue belongs to the Section Emerging Contaminants)

Migration and Transformation of Emerging Pollutants and Improvement of Water Quality

edited by Shibao Lu and

Liang Pei

submission deadline 30 Nov 2025 | Viewed by 261 | Submission Open

Keywords: pollutant fate and transport; emerging contaminants; water remediation technologies; environmental nanotechnology; hydrobiogeochemical cycles; smart water management

From Detection to Risk: Data-Driven Advances in Analytical Chemistry and Toxicology

edited by

Nikiforos Alygizakis

submission deadline 30 Nov 2025 | Viewed by 191 | Submission Open

Keywords: analytical chemistry; computational mass spectrometry; toxicology; exposure assessment; chemical prioritization; mixture toxicity; environmental risk assessment

(This special issue belongs to the Section Novel Methods in Toxicology Research)

Biomonitoring for Emerging Contaminants: From Detection to Risk Assessment

edited by Wenlong Li

submission deadline 10 Dec 2025 | 2 articles | Viewed by 1652 | Submission Open

Keywords: biomonitoring; emerging contaminants; risk assessment; detection; identification

Selected Papers from the 2nd International Online Conference on Toxics (IOCTO2025)

edited by

Xiaojun Luo

Mingce Long

, Patricia Ruiz and Maria João Bebianno

submission deadline 10 Dec 2025 | Viewed by 648 | Submission Open

Keywords: toxicology methods; toxicological mechanisms; organ toxicity; predictive toxicology

Evaluation and Biomonitoring of Potentially Toxic and Rare Earth Elements

edited by Ángel Rodríguez Hernández,

Manuel L Zumbado

and Carmen José Mateos Vega

submission deadline 19 Dec 2025 | 1 articles | Viewed by 816 | Submission Open

Keywords: potentially toxic elements (PTEs); rare earth elements (REEs); human biomonitoring; animal biomonitoring; environmental pollution; toxicological effects; risk assessment; oxidative stress; public health

Editorial Board Members’ Collection Series: Endocrine Disrupting Chemicals

edited by

Eduardo Rocha

and

Jing Liu

submission deadline 20 Dec 2025 | 3 articles | Viewed by 9338 | Submission Open

Keywords: EDCs; endocrine disruption; endocrine disorders; one health; xenohormones; environmental toxicology; mixture toxicity; plastics; pollution; reproductive toxicology

(This special issue belongs to the Section Emerging Contaminants)

Understanding the Trafficking of Toxic Metal(loid)s within Cells

edited by

Maikel Rosabal

and

Jürgen Gailer

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1432 | Submission Open

Keywords: subcellular toxicity; metal interactions; subcellular targets; molecular toxicity; organelles; detoxification; adverse effects; aquatic and terrestrial animals; human models

(This special issue belongs to the Section Metals and Radioactive Substances)

Environmental Toxicology and Risk Assessment of Priority Substances

edited by

Xin Zheng

, Tianxu Zhang and Shuhui Men

submission deadline 28 Dec 2025 | 7 articles | Viewed by 13483 | Submission Open

Keywords: Environmental toxicology; Risk assessment; Priority substances; New Approach Methodologies (NAMs); Emerging contaminant monitoring; Toxicity effects; Microcosm experiments

(This special issue belongs to the Section Emerging Contaminants)

Heavy Metals and Pesticide Residue Remediation in Farmland

edited by Ying Huang

submission deadline 30 Dec 2025 | 1 articles | Viewed by 706 | Submission Open

Keywords: heavy metal; pesticide residues; photocatalytic degradation; pollution evaluation; rice; combined pollution; phytoremediation; source; transfer; and accumulation

(This special issue belongs to the Section Toxicity Reduction and Environmental Remediation)

Toxic Mode of Action, Toxicity Testing, and Health Risks of Environmental Pollutants

edited by Weiwei Zheng and

Yuanyuan Ruan

submission deadline 31 Dec 2025 | 7 articles | Viewed by 26940 | Submission Open

Keywords: mode of action; toxicity testing; health risks; risk assessment; environmental pollutants

(This special issue belongs to the Section Exposome Analysis and Risk Assessment)

Unraveling the Health Impacts of Air Pollution: Assessments and Mechanisms

edited by

Ting Wang

, Tingting Ku and

Jia Xu

submission deadline 31 Dec 2025 | 8 articles | Viewed by 12199 | Submission Open

Keywords: air pollution; exposure assessment; epidemiological study; toxic mechanisms; key components; health effects

(This special issue belongs to the Section Air Pollution and Health)

The Environment and Reproduction: Toxicity Assessment of Pollutant Exposure

edited by

Luigi Montano

submission deadline 31 Dec 2025 | 1 articles | Viewed by 9477 | Submission Open

Keywords: environmental toxicology; reproductive toxicity; pollutant exposure; endocrine disruptors; chemical pollutants; ecotoxicology; teratogenicity; bioaccumulation

(This special issue belongs to the Section Reproductive and Developmental Toxicity)

Impact of Per- and Polyfluoroalkyl Substances (PFAS) on Aquatic Animals: Immunotoxicity, Endocrine Disruption, and Beyond

edited by

Maurizio Manera

and

Luisa Giari

submission deadline 31 Dec 2025 | 3 articles | Viewed by 9316 | Submission Open

Keywords: new and old PFAS; animal model; one health; biomarker; immune system; endocrine system; toxic effects; in vivo and in vitro exposures

(This special issue belongs to the Section Ecotoxicology)

Ototoxic Chemical Exposures and Public Health

edited by

Thais C. Morata

, Gregory Zarus and Krystin Carlson

submission deadline 31 Dec 2025 | 2 articles | Viewed by 9219 | Submission Open

Keywords: early detection; diagnosis; treatment; prevention; occupational exposures; hearing; vestibular/balance; tinnitus/ringing

(This special issue belongs to the Section Human Toxicology and Epidemiology)

Biomass Conversion and Organic Waste Utilization in Wastewater

edited by

Tingting Zhu

, Zisheng Zhao and Lihui Yang

submission deadline 31 Dec 2025 | 4 articles | Viewed by 6648 | Submission Open

Keywords: organic wastewater; resource recovery; biomass conversion; added value products; energy recovery

(This special issue belongs to the Section Toxicity Reduction and Environmental Remediation)

Carbon-Based Materials for Pollutant Immobilization and Removal in Soil and Water

edited by

Jianxin Fan

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4914 | Submission Open

Keywords: carbon-based materials; emerging pollutants; heavy metals; immobilization; removal

(This special issue belongs to the Section Toxicity Reduction and Environmental Remediation)

The Neuroexposome: Integrating Exposures with Physiology to Understand Brain Health and Disease

edited by Megan Mahoney and

Jennifer L. Freeman

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4115 | Submission Open

Keywords: exposome; exposomics; neuroexposome; neurodegeneration; neurotoxicology; neurodevelopment; developmental origins of health and disease (DOHAD)

(This special issue belongs to the Section Neurotoxicity)

Impact of Pollutants on Aquatic Ecosystems and Food Safety

edited by Francesca Falco

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4008 | Submission Open

Keywords: multi-stress; enviromental biodiversity; cascading effect; emerging contaminants; ecotoxicology; biomarkers

(This special issue belongs to the Section Emerging Contaminants)

Advances in Computational Methods of Studying Exposure to Chemicals

edited by Patricia Ruiz and Wei-Chun Chou

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3709 | Submission Open

Keywords: computational toxicology; machine learning; quantitative structure-activity relationship (QSAR); in silico modeling; molecular docking and molecular dynamics simulations; PBPK and PK modeling; fate and transport modeling; high-throughput screening (HTS); integrated testing strategies (ITS); artificial intelligence; risk assessment; adverse outcome pathway (AOP); new approach methodologies (NAMs); chemical mixtures

(This special issue belongs to the Section Novel Methods in Toxicology Research)

Environmental Contaminant Exposure and Intake from Agricultural Products

edited by Sara Lambiase and

Mauro Esposito

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3060 | Submission Open

Keywords: persistent organic pollutants; metals and metalloids; emerging contaminants; targeted and untargeted analyses; food safety; feed safety; risk assessment

(This special issue belongs to the Section Agrochemicals and Food Toxicology)

Perspectives in Veterinary Toxicology and One Health

edited by

Wilson Kiiza Rumbeiha

and Abdel-Razak Kadry

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2663 | Submission Open

Keywords: climate change and animal health; animals as biosentinels of environmental pollution; pollutants and animal health; one health toxicology; veterinary toxicology; environmental toxicants modulating animal health

Ecotoxicological Effects of Microplastics on the Soil Environment

edited by

Rogers Wainkwa Chia

, Charles Amanze and Modupe Elizabeth Ojewumi

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2056 | Submission Open

Keywords: microplastics; soil ecosystems; soil fertility; food security; ecotoxicological risks; soil contamination; sustainable waste management

(This special issue belongs to the Section Ecotoxicology)

Biomarkers of Oxidative Stress from Environmental and Occupational Exposure: Implications for Health Risk Assessment

edited by

Ata Rafiee

, Peter Sly and Mohammad Hoseini

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2045 | Submission Open

Keywords: biomarkers; human biomonitoring; health risk assessment; oxidative stress

(This special issue belongs to the Section Exposome Analysis and Risk Assessment)

Applicability of New Approach Methodologies (NAMs) to Skin Sensitization: Insights from Industry and Regulatory Perspectives

edited by Gertrude-Emilia Costin and Argel Islas-Robles

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1645 | Submission Open

Keywords: skin sensitization; allergic contact dermatitis; new approach methodologies; regulatory testing; defined approaches; adverse outcome pathway; cosmetic industry; medical devices; mixtures; botanicals

(This special issue belongs to the Section Novel Methods in Toxicology Research)

Endocrine Disruptors and Persistent Organic Pollutants: Their Impact on the Environment and Human Health

edited by Euripides G. Stephanou and

Antonis Myridakis

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1628 | Submission Open

Keywords: biomonitoring of EDCs and POPs; Prenatal exposure to mixtures of endocrine-disrupting chemicals and respiratory health in children; exposure to POPs and emotional and behavioral outcomes from early childhood to adolescence

(This special issue belongs to the Section Exposome Analysis and Risk Assessment)

Pharmacological Intervention Against Toxicity of Environmental Pollutants and Stresses

edited by

Dayong Wang

Natalia Krasteva

and Tianshu Wu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1491 | Submission Open

Keywords: toxicology; ecotoxicology; pharmacology; environmental pollutant; environmental stress; health protection

(This special issue belongs to the Section Human Toxicology and Epidemiology)

Environmental Contamination, Toxic Effect, and Risk Assessment of Microplastics and Plastic Additives

edited by

Yu Wang

Chu Peng

and

Lili Rong

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1481 | Submission Open

Keywords: microplastics; plastic additives; environmental contamination; biomonitoring; bioaccumulation; toxicity mechanism; ecological risk assessment; human health effect

(This special issue belongs to the Section Emerging Contaminants)

Environmental Behavior and Migration Mechanism of Microplastics

edited by