Environmental Contamination, Toxic Effect, and Risk Assessment of Microplastics and Plastic Additives

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Emerging Contaminants".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1033

Special Issue Editors

College of Environmental Science and Engineering, Nankai University, Tianjin, 300350, China
Interests: emerging contaminants; persistent organic pollutants; environmental chemistry; environmental behavior; risk assessment
Special Issues, Collections and Topics in MDPI journals
College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China
Interests: emerging contaminants; microbial ecology; environmental behavior

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Guest Editor Assistant
College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China
Interests: emerging contaminants; environmental behavior; soil ecology; microbial interactions; soil functions

Special Issue Information

Dear Colleagues,

The widespread presence of microplastics and their associated chemical additives in the environment has become a pressing global concern. Microplastics persist in ecosystems for decades, accumulating in terrestrial, aquatic, and even atmospheric environments. Due to their small size and resistance to degradation, they are easily ingested by organisms, leading to bioaccumulation and potential biomagnification through food webs. Furthermore, plastic additives—such as plasticizers, flame retardants, and antioxidants—can leach into the environment, exacerbating toxicity risks to biota and humans. Emerging evidence suggests that microplastics and their additives may induce oxidative stress, endocrine disruption, immunotoxicity, and other adverse effects in exposed organisms, raising urgent questions about their long-term ecological and health impacts.

This Special Issue, “Environmental Contamination, Toxic Effect, and Risk Assessment of Microplastics and Plastic Additives”, seeks to compile high-quality original research and review articles that address, but are not limited to, the following key topics: (i) Occurrence and Fate: Monitoring and modeling the distribution, transport, and transformation of microplastics and plastic additives in different environmental matrices; (ii) Toxicological Mechanisms and Ecological Risks: Investigating the physiological and molecular toxicity of microplastics and plastic additives in aquatic and terrestrial organisms, and evaluating their ecological consequences in natural ecosystems; and (iii) Human Exposure and Health Risks: Assessing pathways of human exposure and potential health effects, including epidemiological and in vitro/in vivo toxicological studies.

We particularly welcome large-scale field studies, long-term ecological observations, and interdisciplinary approaches combining environmental chemistry, toxicology, and risk assessment. This Special Issue aims to advance our scientific understanding of the growing threat of microplastics and their additives to environmental and human health.

Dr. Yu Wang
Dr. Chu Peng
Guest Editors

Dr. Lili Rong
Guest Editor Assistant

Manuscript Submission Information

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Keywords

  • microplastics
  • plastic additives
  • environmental contamination
  • biomonitoring
  • bioaccumulation
  • toxicity mechanism
  • ecological risk assessment
  • human health effect

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Published Papers (1 paper)

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Research

21 pages, 15682 KB  
Article
Influence of Microplastics on Manifestations of Experimental Chronic Colitis
by Natalia Zolotova, Maria Silina, Dzhuliia Dzhalilova, Ivan Tsvetkov, Nikolai Fokichev and Olga Makarova
Toxics 2025, 13(8), 701; https://doi.org/10.3390/toxics13080701 - 21 Aug 2025
Viewed by 806
Abstract
Environmental pollution with microplastics (MPs) can have a negative impact on human health. Certain findings point to the relationship between MP and the development of inflammatory bowel diseases (IBD). We investigated the effect of MP consumption on the severity of chronic colitis in [...] Read more.
Environmental pollution with microplastics (MPs) can have a negative impact on human health. Certain findings point to the relationship between MP and the development of inflammatory bowel diseases (IBD). We investigated the effect of MP consumption on the severity of chronic colitis in male C57BL/6 mice. The MP effect was modeled by drinking water consumption with a suspension of 5 μm PS particles at a concentration of 10 mg/L replacement for 12 weeks. Chronic colitis was induced by three seven-day cycles of 1% DSS consumption (starting from the 8th, 29th and 50th days of the experiment). We investigated inflammatory infiltration, the goblet cell volume fraction and the highly sulfated and neutral mucins content in them, the endocrine cell number, the ulcerative-inflammatory process prevalence, changes in the gene’s expression encoding tight junction proteins, glycocalyx components proapoptotic factor Bax and proliferation marker Mki67 in the colon, and TNFα, IL-1β, IL-6 and IL-10 cytokines content in the serum. In healthy mice, MP did not cause pathological changes in the colon; however, indirect data indicate an increase in colon permeability. In chronic colitis, MP leads to higher prevalence of all pathological changes in general, and ulcers in particular, in a greater number of crypt abscesses and enteroendocrine cells. MP consumption leads to a more severe chronic colitis course. Full article
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