Special Issue "Zebrafish as a Model for Pharmacological and Toxicological Research"

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Toxicology".

Deadline for manuscript submissions: 31 August 2022 | Viewed by 576

Special Issue Editor

Dr. Pavla Lakdawala
E-Mail Website
Guest Editor
Department of Animal Protection and Welfare & Veterinary Public Health, University of Veterinary Sciences Brno, Palackeho tr. 1, Brno, Czech Republic
Interests: ecotoxicology; aquatic ecosystems; fish; food safety; pharmaceuticals; pesticides
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

For decades, zebrafish has been a prefered model organism used in various research fields, such as toxicology, developmental biology, medicine, and many others. Zebrafish popularity is mainly based on small body size, easy husbandry, rapid development, and optical  translucency of early life stages. Moreover, the development of zebrafish is well-described and the genome fully sequenced. Thanks to that, zebrafish can be used to investigate the mechanism of action of various substances, evaluate ecotoxicity, and environmental toxicants (including pharmaceutical residues in surface waters), and can be used in new drug development.

In this Special Issue, we welcome any novel studies with a focus on using zebrafish as a model for pharmacological and toxicological research.

Dr. Pavla Lakdawala
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • zebrafish
  • pharmaceutical residues
  • model organis
  • aquatic ecotoxicology

Published Papers (1 paper)

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Research

Article
Environmental Risk Assessment of Dexamethasone Sodium Phosphate and Tocilizumab Mixture in Zebrafish Early Life Stage (Danio rerio)
Toxics 2022, 10(6), 279; https://doi.org/10.3390/toxics10060279 - 25 May 2022
Viewed by 382
Abstract
Pharmaceuticals are widely regarded as a menace to the aquatic environment. The constant consumption of biologically active chemicals for human health has been matched by an increase in the leaking of these compounds in natural habitats over the last two decades. This study [...] Read more.
Pharmaceuticals are widely regarded as a menace to the aquatic environment. The constant consumption of biologically active chemicals for human health has been matched by an increase in the leaking of these compounds in natural habitats over the last two decades. This study was aimed to evaluate the molecular pathway underling the developmental toxicity of exposure in the ecological environment. Zebrafish embryos were exposed at doses of dexamethasone sodium phosphate (DEX) 1 μmol/L, tocilizumab 442.1 μmol/L and dexamethasone + tocilizumab (1 μmol/L and 442.1 μmol/L, respectively) from 24 h post-fertilization (hpf) to 96 hpf. This study confirmed that DEX exposure in association with tocilizumab 442.1 μmol/L at 1 μmol/L (non-toxic concentration) affected the survival and hatching rate, morphology score, and body length. Additionally, it significantly disturbed the antioxidant defense system in zebrafish larvae. Furthermore, a DEX 1 μmol/L and tocilizumab 442.1 μmol/L association also increased the production of apoptosis-related proteins (caspase-3, bax, and bcl-2). Full article
(This article belongs to the Special Issue Zebrafish as a Model for Pharmacological and Toxicological Research)
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