Special Issue "Toxicokinetics of Chemicals in Consumer Products"

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Toxicology".

Deadline for manuscript submissions: 27 September 2022 | Viewed by 378

Special Issue Editor

Prof. Dr. Kyu-Bong Kim
E-Mail Website
Guest Editor
College of Pharmacy, Dankook University, 119 Dandae-ro, Cheonan 31116, Korea
Interests: toxicometabolomics; toxicokinetics; risk assessment; drugs

Special Issue Information

Dear Colleagues, 

The importance of applying toxicokinetic information for toxicity testing and chemical safety assessment has been increasing. In this Special Issue, we would like to invite manuscripts describing not only the toxicokinetics and toxicodynamics of chemicals for safety assessment but also research that contributes to such investigations.

The specific scope of this Special Issue includes but is not limited to:

  • Analytical methods of toxic chemicals;
  • In vitro, ex vivo, and/or in vivo research that contributes to characterize toxicokinetics and toxicodynamics for safety assessment;
  • Modeling approaches, including to predict human toxicokinetics and toxicodynamics;
  • New toxicokinetic/toxicodynamic experimental methodology or modeling approaches that contribute to a future safety assessment.

The Special Issue will give insight into the toxicokinetics and toxicodynamics that identify chemicals in consumer products, and it is expected to stimulate discussion on the way forward in developing new risk assessment strategies for capturing complex target system toxicity.

Prof. Dr. Kyu-Bong Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • toxicokinetics
  • chemicals
  • metabolism
  • safety assessment

Published Papers (1 paper)

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Research

Article
Pharmacokinetics and the Dermal Absorption of Bromochlorophene, a Cosmetic Preservative Ingredient, in Rats
Toxics 2022, 10(6), 329; https://doi.org/10.3390/toxics10060329 - 16 Jun 2022
Viewed by 285
Abstract
The cosmetic industry has flourished in recent years. Accordingly, the safety of cosmetic ingredients is increasing. Bromochlorophene (BCP) is a commonly used cosmetic preservative. To evaluate the effects of BCP exposure, in vitro dermal absorption and in vivo pharmacokinetic (PK) studies were conducted [...] Read more.
The cosmetic industry has flourished in recent years. Accordingly, the safety of cosmetic ingredients is increasing. Bromochlorophene (BCP) is a commonly used cosmetic preservative. To evaluate the effects of BCP exposure, in vitro dermal absorption and in vivo pharmacokinetic (PK) studies were conducted using gel and cream formulations. The Franz diffusion cell system and rat dorsal skin were used for tests according to the Korea Ministry of Food and Drug Safety guidelines for in vitro skin absorption methods. After the dermal application (1.13 mg/cm2) of BCP in the gel and cream formulations, liquid chromatography–mass spectrometry (LC–MS/MS) was used to evaluate the amount of BCP that remained unabsorbed on the skin (WASH), and that was present in the receptor fluid (RF), stratum corneum (SC), and (epi)dermis (SKIN). The total dermal absorption rate of BCP was 7.42 ± 0.74% for the gel formulation and 1.5 ± 0.9% for the cream formulation. Total recovery in an in vitro dermal absorption study was 109.12 ± 8.79% and 105.43 ± 11.07% for the gel and cream formulations, respectively. In vivo PK and dermal absorption studies of BCP were performed following the Organization for Economic Cooperation and Development guidelines 417 and 427, respectively. When intravenous (i.v.) pharmacokinetics was performed, BCP was dissolved in glycerol formal and injected into the tail vein (n = 3) of the rats at doses of 1 and 0.2 mg/kg. Dermal PK parameters were estimated by the application of the gel and cream formulations (2.34 mg/kg of BCP as an active ingredient) to the dorsal skin of the rats. Intravenous and dermal PK parameters were analyzed using a non-compartmental method. The dermal bioavailability of BCP was determined as 12.20 ± 2.63% and 4.65 ± 0.60% for the gel and cream formulations, respectively. The representative dermal absorption of BCP was evaluated to be 12.20 ± 2.63% based on the results of the in vivo PK study. Full article
(This article belongs to the Special Issue Toxicokinetics of Chemicals in Consumer Products)
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