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Toxics
Special Issues
Air Pollutant Exposure and Respiratory Injury
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Air Pollutant Exposure and Respiratory Injury

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Air Pollution and Health".

Deadline for manuscript submissions: closed (27 December 2024) | Viewed by 1290

Special Issue Editors

Prof. Dr. Miao He

E-Mail Website
Guest Editor
Environmental Health, School of Public Health, China Medical University, Shenyang 110122, China
Interests: environmental exposure and health hazard; inhalable particle and respiratory inflammation
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Wenjun Ding

E-Mail Website
Guest Editor
College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
Interests: environment and health; diabetes mellitus; obesity; oxidative stress
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Kefang Lai

E-Mail Website
Guest Editor
State Key Laboratory of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China
Interests: pathogenesis of bronchial asthma and chronic cough
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Exposure to air pollution is a major contributor to the pathogenesis of respiratory diseases worldwide. The Special Issue on “Air Pollutant Exposure and Respiratory Injury” will aim to highlight the latest advances relating to respiratory injuries.

As new pollutants have been ubiquitously detected in indoor air and atmospheric systems, the air pollutants in this Special Issue are not limited to traditional pollutants (PM2.5, PM10, SO2, etc.), but also include new pollutants such as microplastics, plasticizers, and perfluorinated compounds.

Emphasis is placed on findings that identify novel hazards and that can be extrapolated to environmental exposures and human respiratory risk. Topics are defined on both the macro (e.g., cell biology, epidemiology, immunology, oncology, pathophysiology, imaging and occupational medicine, etc.) and molecular (genomic, transcriptomic, metabolic, etc.) scales. Authors are invited to submit original research papers, reviews, and short communications.

Prof. Dr. Miao He
Prof. Dr. Wenjun Ding
Prof. Dr. Kefang Lai
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • epidemiology
  • allergy
  • airway inflammation
  • endoplasmic reticulum homeostasis
  • mitochondrial dysfunction
  • oxidative stress

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Related Special Issue

Published Papers (2 papers)

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Research

12 pages, 1547 KiB  
Article
Modelling Cumulative Effects of Air Pollution on Respiratory Illnesses by Performing Spline Estimation of Constrained, Additive Single-Index Model
by Xingfa Zhang, Siyu Wang, Quanxi Shao, Sijia Wang and Yuezi Wei
Toxics 2025, 13(3), 149; https://doi.org/10.3390/toxics13030149 - 21 Feb 2025
Viewed by 359
Abstract
It is widely recognised that air pollutants including sulphur dioxide (SO2), respirable suspended particulates (PM10), nitrogen oxides (NOx), nitrogen dioxide (NO2), and ozone (O3), as well as weather conditions such as temperature (Temp) and relative humidity (RH), [...] Read more.
It is widely recognised that air pollutants including sulphur dioxide (SO2), respirable suspended particulates (PM10), nitrogen oxides (NOx), nitrogen dioxide (NO2), and ozone (O3), as well as weather conditions such as temperature (Temp) and relative humidity (RH), are major causes of respiratory illnesses. To quantify the unknown and highly nonlinear relationships between these factors and respiratory illness, and the cumulative effect from exposure to symptoms, in this paper, we propose a semiparametric index model with constraints to capture the cumulative effect additively and the nonlinearity nonparametrically. As a case study, the model is applied to a dataset from the Hong Kong SAR. As the data period includes the SARS (severe acute respiratory syndrome) epidemic in 2003, we further construct a growth curve model to account for the extra impact of public health measures. The results show that the effects of SO2, NO2, and PM10 decay quickly, while the other pollutants have a period of stable accumulation (18–38 days for O3, 2–30 days for NOx, 1–13 days for RH, and 4–12 days for temperature). The results also show that the proposed model has a better fitting performance than previous models and hence has potential applications in health monitoring programs. Full article
(This article belongs to the Special Issue Air Pollutant Exposure and Respiratory Injury)
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17 pages, 2405 KiB  
Article
Impact of Emission Standards on Fine Particulate Matter Toxicity: A Long-Term Analysis in Los Angeles
by Mohammad Mahdi Badami, Yashar Aghaei and Constantinos Sioutas
Toxics 2025, 13(2), 140; https://doi.org/10.3390/toxics13020140 - 18 Feb 2025
Viewed by 575
Abstract
This study examines long-term trends in fine particulate matter (PM2.5) composition and oxidative potential in Los Angeles based on data from the University of Southern California’s Particle Instrumentation Unit, with chemical composition retrieved from the EPA’s Air Quality System (AQS). While [...] Read more.
This study examines long-term trends in fine particulate matter (PM2.5) composition and oxidative potential in Los Angeles based on data from the University of Southern California’s Particle Instrumentation Unit, with chemical composition retrieved from the EPA’s Air Quality System (AQS). While regulatory interventions have reduced PM2.5 mass concentration and primary combustion-related components, our findings reveal a more complex toxicity pattern. From 2001 to 2008, the PM2.5 oxidative potential, measured via the dithiothreitol (DTT) assay, declined from ~0.84 to ~0.16 nmol/min/m3 under stringent tailpipe controls. However, after this initial decline, PM2.5 DTT stabilized and gradually increased from ~0.35 in 2012 to ~0.97 nmol/min/m3 by 2024, reflecting the growing influence of non-tailpipe emissions such as brake/tire wear. Metals, such as iron (Fe, ~150 ng/m3) and zinc (Zn, ~10 ng/m3), remained relatively stable as organic and elemental carbon (OC and EC) declined, resulting in non-tailpipe contributions dominating PM2.5 toxicity. Although PM2.5 mass concentrations were effectively reduced, the growing contribution of non-tailpipe emissions (e.g., brake/tire wear and secondary organic aerosols) underscores the limitations of mass-based standards and tailpipe-focused strategies. Our findings emphasize the need to broaden regulatory strategies, targeting emerging sources that shape PM2.5 composition and toxicity and ensuring more improvements in public health outcomes. Full article
(This article belongs to the Special Issue Air Pollutant Exposure and Respiratory Injury)
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