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Toxics
Special Issues
Environmental Carcinogens Exposure: Molecular Mechanisms, Genotoxicity and Prevention Strategies
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Environmental Carcinogens Exposure: Molecular Mechanisms, Genotoxicity and Prevention Strategies

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Exposome Analysis and Risk Assessment".

Deadline for manuscript submissions: closed (20 September 2023) | Viewed by 2142

Special Issue Editors

Dr. Yi-Shiou Chiou

E-Mail Website
Guest Editor
College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan
Interests: toxicology; functional food; tumor biology; cancer; chemoprevention and chemotherapy
Special Issues, Collections and Topics in MDPI journals
Dr. Yan-Qin Tan

E-Mail Website
Guest Editor
Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China
Interests: food safety and toxicology; functional food; phytochemicals; drug metabolism; oncotherapeutics; metabolic diseases

Special Issue Information

Dear Colleagues,

Environmental pollutants, including natural and anthropogenic substances such as air pollutants, food and soil contaminants, radiation and chemicals present in the environment constitute a grave threat to human health. The World Health Organization (WHO) estimated that environmental risks contribute to around 20% of the cancer burden worldwide. Since 1971, the International Agency for Research on Cancer (IARC) of the World Health Organization (WHO) has evaluated more than 1000 agents using IARC monographs, and more than 500 have been classified as carcinogenic (Group 1), probably carcinogenic (Group 2A) or possibly carcinogenic (Group 2B) to. This Special Issue of Toxics focuses on the genotoxicity and prevention strategies associated with exposure to carcinogens in the environment. Original research, reviews, meta-analyses, short communications, and commentaries covering the aforementioned topics are welcome and expected to add relevant information to the current knowledge.

Dr. Yi-Shiou Chiou
Dr. Yan-Qin Tan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • environmental pollutants
  • cosmetics toxicology
  • food contaminants
  • food safety
  • radioactive elements
  • nanoparticles
  • health risk assessment and biological mechanisms
  • carcinogens and carcinogenesis
  • health hazards and mechanisms
  • genotoxicity and epigenetic toxicity

Published Papers (1 paper)

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Research

19 pages, 5430 KiB  
Article
In Vivo Investigation of the Effect of Dietary Acrylamide and Evaluation of Its Clinical Relevance in Colon Cancer
by Christiana M. Neophytou, Andromachi Katsonouri, Maria-Ioanna Christodoulou and Panagiotis Papageorgis
Toxics 2023, 11(10), 856; https://doi.org/10.3390/toxics11100856 - 13 Oct 2023
Viewed by 1637
Abstract
Dietary exposure to acrylamide (AA) has been linked with carcinogenicity in the gastrointestinal (GI) tract. However, epidemiologic data on AA intake in relation to cancer risk are limited and contradictory, while the potential cancer-inducing molecular pathways following AA exposure remain elusive. In this [...] Read more.
Dietary exposure to acrylamide (AA) has been linked with carcinogenicity in the gastrointestinal (GI) tract. However, epidemiologic data on AA intake in relation to cancer risk are limited and contradictory, while the potential cancer-inducing molecular pathways following AA exposure remain elusive. In this study, we collected mechanistic information regarding the induction of carcinogenesis by dietary AA in the colon, using an established animal model. Male Balb/c mice received AA orally (0.1 mg/kg/day) daily for 4 weeks. RNA was extracted from colon tissue samples, followed by RNA sequencing. Comparative transcriptomic analysis between AA and mock-treated groups revealed a set of differentially expressed genes (DEGs) that were further processed using different databases through the STRING-DB portal, to reveal deregulated protein–protein interaction networks. We found that genes implicated in RNA metabolism, processing and formation of the ribosomal subunits and protein translation and metabolism are upregulated in AA-exposed colon tissue; these genes were also overexpressed in human colon adenocarcinoma samples and were negatively correlated with patient overall survival (OS), based on publicly available datasets. Further investigation of the potential role of these genes during the early stages of colon carcinogenesis may shed light into the underlying mechanisms induced by dietary AA exposure. Full article
(This article belongs to the Special Issue Environmental Carcinogens Exposure: Molecular Mechanisms, Genotoxicity and Prevention Strategies)
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