Using Metabolomics, Exposomics and Epigenomics to Bridge Critical Knowledge Gaps of Chemical Exposures in Fish and Aquatic Invertebrates

Dear Colleagues,

The goal of this Special Issue is to publish papers that apply metabolomics, exposomics and epigenomics to bridge critical knowledge gaps of chemical exposures and aid the development of adverse outcome pathways (AOPs) in fish and aquatic invertebrates.

Chemical pollution is becoming increasingly pervasive in the aquatic environment, and is responsible for a wide variety of adverse effects in wildlife. Traditionally, research efforts have focused on the application of effect-based assessment for apical endpoints without considering the underlying mechanisms that link cause to effect. Therefore, our understanding of mechanisms driving adverse effects is limited (especially in non-model species, including invertebrates), and hypothesis-driven approaches may be too constrained where fundamental biological knowledge of different species and mechanistic understanding of chemical interference is lacking. The purpose of this Special Issue is to highlight the application of exciting and disruptive research using metabolomics, exposomics and epigenomics that will bridge critical knowledge gaps of chemical exposures and aid the development of adverse outcome pathways (AOPs) in fish and aquatic invertebrates. We invite high-quality original research papers detailing in vitro and in vivo (field and laboratory) studies, with an emphasis on fish and aquatic invertebrates. While underlying mechanisms may not be fully characterized, the research should attempt to develop a plausible mechanistic basis for apical effects and include realistic and measured chemical exposure scenarios where possible. Research on single chemicals, mixtures, complex environmental samples and cross-species comparisons are welcome.

Dr. Edwin Routledge
Dr. Thomas Miller
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• metabolomics
• exposomics
• epigenomics
• chemical exposures
• fish
• aquatic invertebrates
• adverse outcome pathways (AOPs)