Emerging Methodologies in Toxicology for Environmental Safety Assessment

Dear Colleagues,

The number of new substances and products being introduced into our daily lives is rapidly increasing and the rate of emergence continues to accelerate. However, the methods available to evaluate their safety are not keeping pace. This widening gap between the need for safety assessments and the capacity to conduct them highlights the urgent necessity for a fundamental shift in toxicology evaluation methods, a shift from primarily in vivo animal studies to in silico assessments, in vitro assays, in vivo assays with lower organisms, and computational modeling for toxicity assessments. Thus, emerging methodologies, such as toxicogenomics, high-throughput screening (HTS) techniques, new approach methodologies (NAMs), and predictive computational models—as well as integrated testing strategies such as adverse outcome pathways (AOPs) or integrated approaches for testing and assessment (IATA) in toxicology—are transforming environmental safety assessments by enhancing our understanding of how contaminants affect humans health and ecosystems. These innovative approaches aim to enhance the precision and efficiency of environmental safety assessments, contributing to more informed decision-making in public health and environmental protection.

As the landscape of toxicology rapidly evolves, the need for safety assessment methods has never been more critical. This Special Issue provides a platform for scientists to showcase cutting-edge research on emerging methodologies. By contributing with your work, you will help shape the future of environmental safety assessment, drive regulatory advancements, and foster a paradigm shift toward more predictive, ethical, and high-impact toxicology. Join us here in advancing science for a safer and more sustainable world!

Dr. Melissa Faria
Dr. Juliette Bedrossiantz
Dr. Miguel Oliveira
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• toxicology
• chemical safety
• emerging contaminants
• integrated approaches
• predictive modeling
• new methodology approaches
• high-throughput screening
• adverse-outcome pathways
• risk assessment
• One Health