(Chemo)biocatalytic Upgrading of Biobased Chemicals and Materials

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Catalysis Enhanced Processes".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 721

Special Issue Editors


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Guest Editor
School of Pharmacy & School of Biological and Food Engineering, Changzhou University, Changzhou 213164, China
Interests: biocatalysis; chemocatalysis; biomass; biobased chemicals; bioenergy

Special Issue Information

Dear Colleagues,

In the pursuit of sustainable development, human society is actively seeking alternatives to fossil fuel consumption. Some organic waste, biobased chemicals, and other materials can be utilized as feedstock to produce a series of high-value-added molecules and biomaterials. Recently, various valorization processes relating to bioresources and bioprocessing have gained increasing attention. This Special Issue of Processes aims to develop novel and efficient processes with robust catalysts for (chemo)biocatalytic upgrading biobased chemicals, biomaterials, and other waste in a sustainable way. The Editors welcome high-quality research papers, reviews, and short communications focusing on this topic. This topic encompasses, but is not limited to, the following:

Machine learning-aided design of chemical and/or biological catalysts, or the synthesis of novel chemical and/or biological catalysts for upgrading biobased chemicals and materials.
Chemical and/or biological transformation in a green and sustainable catalytic medium.
New strategies (e.g., photoenzymatic catalysis, electroenzymatic catalysis, chemoenzymatic catalysis, etc.) to manufacture valuable pharmaceutical intermediates, biofuel molecules, and biobased coumpounds.
Case studies addressing the (chemo)biocatalytic upgrading of typical and specific waste (biomass, food residue, Chinese medicine residue, plastics, polymers, etc.).

Prof. Dr. Yu-Cai He
Dr. Bo Fan
Guest Editors

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Keywords

  • biocatalysis
  • chemobiological upgrading
  • biomass pretreatment
  • value-added chemicals
  • biofuels
  • biorefinery
  • process integration

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Published Papers (1 paper)

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Research

14 pages, 1705 KB  
Article
Bioproduction of Gastrodin from Lignin-Based p-Hydroxybenzaldehyde Through the Biocatalysis by Coupling Glycosyltransferase UGTBL1-Δ60 and Carbonyl Reductase KPADH
by Bao Fan, Jiale Xiong, Cuiluan Ma and Yu-Cai He
Processes 2026, 14(1), 55; https://doi.org/10.3390/pr14010055 - 23 Dec 2025
Viewed by 496
Abstract
Gastrodin is a bioactive component of traditional Chinese medicine, exhibiting anti-cancer, anti-inflammatory, antioxidant and neuroprotective properties. It has broad application prospects in health foods, pharmaceuticals and cosmetics. In recent years, the conversion of biomass-derived aldehydes into high-value-added chemicals has garnered widespread attention. In [...] Read more.
Gastrodin is a bioactive component of traditional Chinese medicine, exhibiting anti-cancer, anti-inflammatory, antioxidant and neuroprotective properties. It has broad application prospects in health foods, pharmaceuticals and cosmetics. In recent years, the conversion of biomass-derived aldehydes into high-value-added chemicals has garnered widespread attention. In this study, gastrodin was biosynthesized via a dual-enzyme coupling system consisting of UGTBL1-Δ60 and KpADH. Specifically, lignin-derived p-hydroxybenzaldehyde was used as the substrate. First, the glycosylation of p-hydroxybenzaldehyde by UGTBL1-Δ60 yielded p-hydroxybenzaldehyde β-glucoside, generating the glycosylation reaction solution. Subsequently, bioreduction of the glycosylation product by KpADH produced gastrodin. Under the optimal reaction conditions (0.05 g/mL KpADH whole cells, 50 mM glucose, pH 7.5 and 30 °C) a gastrodin yield of 82.8% was achieved within 12 h. Moreover, both UGTBL1-Δ60 and KpADH retained high catalytic activity after multiple reaction cycles. This study establishes a green and efficient biocatalytic approach for gastrodin synthesis, and also provides new insights into the high-value utilization of lignin. Full article
(This article belongs to the Special Issue (Chemo)biocatalytic Upgrading of Biobased Chemicals and Materials)
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