Advanced Modeling of Biomanufacturing Processes

Dear Colleagues,

The ultimate goal of biotechnology is to reach a degree of maturity that would enable a fully integrated, sustainable, bio-based economy with a minimal non-recyclable waste and emissions footprint. At the core of this future manufacturing challenge lies our ability to reliably manipulate cellular function both at the metabolic and the bioprocess engineering level in order to design novel, robust and economically viable bioprocesses. Scientists and Engineers alike highlight the need for sophisticated and robust mathematical modelling approaches to expedite developments and facilitate new discoveries. 

The aim of this special issue of Processes is to attract high-quality original research contributions and review articles in the field of advanced bioprocess modeling of bio-based manufacturing processes. This could include multi-scale modelling approaches and/or rigorous hybrid modelling approaches that combine two or more sub-models to capture experimental and/or mechanistic information at various scales (e.g. molecular/multi-omics, kinetic/polymerization, metabolic/pathway, population balance, macroscopic/mechanistic, computational fluid dynamics, bioreactor, plant-wide, techno-economic evaluation and life-cycle-analysis). The objective is to demonstrate the significance of existing and novel simulation tools to qualitatively comprehend and describe complex biochemical and biological mechanisms and quantitatively predict and optimize the production of valuable chemicals, proteins or enzymes. Specific topics for the special issue include but are not limited to: 

• Modeling and intensification of microbial, mammalian, algal and enzymatic production processes.
• Upstream and downstream bioprocess simulation, control and optimization.
• Innovative concepts for integrating multiple models at different scales.
• Advanced numerical methods for model calibration and simulation of complex bio-based systems.
• Analysis and validation of multi-scale models and simulations.
• Integrated multi-scale simulation platforms for whole-process sustainability analysis.

Dr. Giannis Penloglou
Dr. Alexandros Kiparissides
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.