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  • Article
  • Open Access
465 Views
17 Pages

Background/Objectives: Radioactive iodine (RAI) therapy is widely used to treat metastatic differentiated thyroid cancer. To investigate physiological determinants of treatment response, a mechanistic model was developed, formulated as a system of co...

  • Case Report
  • Open Access
1,618 Views
7 Pages

Treatment of Resistant TPM3::ALK + Fusion Protein Metastatic Inflammatory Myofibroblastic Tumor with ALK Targeting and Immune Checkpoint Inhibitor Combined Therapy

  • Leonardo Simonelli,
  • Sebastian James Khairkhahan,
  • Francesco Alessandrino,
  • Elizabeth Anne Montgomery and
  • Gina D’Amato

Background and Clinical Significance: Inflammatory myofibroblastic tumors (IMTs) are rare neoplasms with low metastatic potential but a high recurrence rate. Approximately 60–80% of IMTs harbor anaplastic lymphoma kinase (ALK) gene rearrangemen...

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Precis. Oncol. - ISSN 3042-7614