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Release Profile of Gentamicin Sulfate from Polylactide-co-Polycaprolactone Electrospun Nanofiber Matrices

1
Department of Drug Sciences, University of Pavia, Viale Taramelli 12/14, 27100 Pavia, Italy
2
Polymerix S.r.l., Via Taramelli 24, 27100 Pavia, Italy
3
Department of Chemistry, University of Pavia, Viale Taramelli 12/14, 27100 Pavia, Italy
*
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(4), 161; https://doi.org/10.3390/pharmaceutics11040161
Received: 10 March 2019 / Revised: 28 March 2019 / Accepted: 30 March 2019 / Published: 3 April 2019
(This article belongs to the Special Issue Recent Development of Electrospinning for Drug Delivery)
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Abstract

The advent and growth of resistance phenomena to antibiotics has reached critical levels, invalidating the action of a majority of antibiotic drugs currently used in the clinical field. Several innovative techniques, such as the nanotechnology, can be applied for creating innovative drug delivery systems designed to modify drug release itself and/or drug administration route; moreover, they have proved suitable for overcoming the phenomenon of antibiotic resistance. Electrospun nanofibers, due to their useful structural properties, are showing promising results as antibiotic release devices for preventing bacteria biofilm formation after surgical operation and for limiting resistance phenomena. In this work gentamicin sulfate (GS) was loaded into polylactide-co-polycaprolactone (PLA-PCL) electrospun nanofibers; quantification and in vitro drug release profiles in static and dynamic conditions were investigated; GS kinetic release from nanofibers was studied using mathematical models. A preliminary microbiological test was carried out towards Staphylococcus aureus and Escherichia coli bacteria. View Full-Text
Keywords: electrospinning; gentamicin sulfate; polylactide-co-polycaprolactone; drug release kinetics electrospinning; gentamicin sulfate; polylactide-co-polycaprolactone; drug release kinetics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Pisani, S.; Dorati, R.; Chiesa, E.; Genta, I.; Modena, T.; Bruni, G.; Grisoli, P.; Conti, B. Release Profile of Gentamicin Sulfate from Polylactide-co-Polycaprolactone Electrospun Nanofiber Matrices. Pharmaceutics 2019, 11, 161.

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