Next Article in Journal
Fabrication of Ion-Crosslinking Aminochitosan Nanoparticles for Encapsulation and Slow Release of Curcumin
Next Article in Special Issue
Bi-Layered Polymer Carriers with Surface Modification by Electrospinning for Potential Wound Care Applications
Previous Article in Journal
Folate Receptor-Targeting and Reactive Oxygen Species-Responsive Liposomal Formulation of Methotrexate for Treatment of Rheumatoid Arthritis
Previous Article in Special Issue
Evaluation of Electrospun Poly(ε-Caprolactone)/Gelatin Nanofiber Mats Containing Clove Essential Oil for Antibacterial Wound Dressing
Open AccessCommunication

Design of a Novel Oxygen Therapeutic Using Polymeric Hydrogel Microcapsules Mimicking Red Blood Cells

1
BioMolecular Engineering Program, Physics and Chemistry Department, Milwaukee School of Engineering, Milwaukee, WI 53202, USA
2
Mechanical Engineering Department, University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA
*
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(11), 583; https://doi.org/10.3390/pharmaceutics11110583
Received: 30 August 2019 / Revised: 20 October 2019 / Accepted: 5 November 2019 / Published: 7 November 2019
(This article belongs to the Special Issue Recent Development of Electrospinning for Drug Delivery)
The goal of this research was to develop a novel oxygen therapeutic made from a pectin-based hydrogel microcapsule carrier mimicking red blood cells. The study focused on three main criteria for developing the oxygen therapeutic to mimic red blood cells: size (5–10 μm), morphology (biconcave shape), and functionality (encapsulation of oxygen carriers; e.g., hemoglobin (Hb)). The hydrogel carriers were generated via the electrospraying of the pectin-based solution into an oligochitosan crosslinking solution using an electrospinning setup. The pectin-based solution was investigated first to develop the simplest possible formulation for electrospray. Then, Design-Expert® software was used to optimize the production process of the hydrogel microcapsules. The optimal parameters were obtained through the analysis of a total of 17 trials and the microcapsule with the desired morphology and size was successfully prepared under the optimized condition. Fourier transform infrared spectroscopy (FTIR) was used to analyze the chemistry of the microcapsules. Moreover, the encapsulation of Hb into the microcapsule did not adversely affect the microcapsule preparation process, and the encapsulation efficiency was high (99.99%). The produced hydrogel microcapsule system shows great promise for creating a novel oxygen therapeutic. View Full-Text
Keywords: artificial red blood cells; electrospinning and electrospray; pectin; oligochitosan; hydrogel; microcapsules artificial red blood cells; electrospinning and electrospray; pectin; oligochitosan; hydrogel; microcapsules
Show Figures

Figure 1

MDPI and ACS Style

Cherwin, A.; Namen, S.; Rapacz, J.; Kusik, G.; Anderson, A.; Wang, Y.; Kaltchev, M.; Schroeder, R.; O’Connell, K.; Stephens, S.; Chen, J.; Zhang, W. Design of a Novel Oxygen Therapeutic Using Polymeric Hydrogel Microcapsules Mimicking Red Blood Cells. Pharmaceutics 2019, 11, 583.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop