Next Article in Journal
In Situ Hydrogel-Forming/Nitric Oxide-Releasing Wound Dressing for Enhanced Antibacterial Activity and Healing in Mice with Infected Wounds
Next Article in Special Issue
Preformulation Study of Electrospun Haemanthamine-Loaded Amphiphilic Nanofibers Intended for a Solid Template for Self-Assembled Liposomes
Previous Article in Journal
Silk Fibroin as a Functional Biomaterial for Drug and Gene Delivery
Previous Article in Special Issue
Quasi-Dynamic Dissolution of Electrospun Polymeric Nanofibers Loaded with Piroxicam
Open AccessArticle

Comparison of Traditional and Ultrasound-Enhanced Electrospinning in Fabricating Nanofibrous Drug Delivery Systems

1
School of Pharmacy, University of Eastern Finland, 70210 Kuopio, Finland
2
Institute of Pharmacy, Faculty of Medicine, University of Tartu, 50411 Tartu, Estonia
3
Department of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, 50411 Tartu, Estonia
4
Electronics Research Laboratory, Department of Physics, University of Helsinki, 00014 Helsinki, Finland
5
Medical Ultrasonics Laboratory, Department of Neuroscience and Biomedical Engineering, Aalto University, 02150 Espoo, Finland
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Pharmaceutics 2019, 11(10), 495; https://doi.org/10.3390/pharmaceutics11100495
Received: 31 August 2019 / Revised: 19 September 2019 / Accepted: 23 September 2019 / Published: 26 September 2019
(This article belongs to the Special Issue Recent Development of Electrospinning for Drug Delivery)
We investigated nozzleless ultrasound-enhanced electrospinning (USES) as means to generate nanofibrous drug delivery systems (DDSs) for pharmaceutical and biomedical applications. Traditional electrospinning (TES) equipped with a conventional spinneret was used as a reference method. High-molecular polyethylene oxide (PEO) and chitosan were used as carrier polymers and theophylline anhydrate as a water-soluble model drug. The nanofibers were electrospun with the diluted mixture (7:3) of aqueous acetic acid (90% v/v) and formic acid solution (90% v/v) (with a total solid content of 3% w/v). The fiber diameter and morphology of the nanofibrous DDSs were modulated by varying ultrasonic parameters in the USES process (i.e., frequency, pulse repetition frequency and cycles per pulse). We found that the USES technology produced nanofibers with higher fiber diameter (402 ± 127 nm) than TES (77 ± 21 nm). An increase of a burst count in USES increased the fiber diameter (555 ± 265 nm) and the variation in fiber size. The slight-to-moderate changes in a solid state (crystallinity) were detected when compared the nanofibers generated by TES and USES. In conclusion, USES provides a promising alternative for aqueous-based fabrication of nanofibrous DDSs for pharmaceutical and biomedical applications. View Full-Text
Keywords: nanotechnology; nanofibers; traditional electrospinning; ultrasound-enhanced electrospinning; drug delivery system nanotechnology; nanofibers; traditional electrospinning; ultrasound-enhanced electrospinning; drug delivery system
Show Figures

Graphical abstract

MDPI and ACS Style

Hakkarainen, E.; Kõrkjas, A.; Laidmäe, I.; Lust, A.; Semjonov, K.; Kogermann, K.; Nieminen, H.J.; Salmi, A.; Korhonen, O.; Haeggström, E.; Heinämäki, J. Comparison of Traditional and Ultrasound-Enhanced Electrospinning in Fabricating Nanofibrous Drug Delivery Systems. Pharmaceutics 2019, 11, 495.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop