Evaluation of Electrospun Poly(ε-Caprolactone)/Gelatin Nanofiber Mats Containing Clove Essential Oil for Antibacterial Wound Dressing
by
Irem Unalan 1
, Stefan J. Endlein 1, Benedikt Slavik 2, Andrea Buettner 2, Wolfgang H. Goldmann 3, Rainer Detsch 1 and Aldo R. Boccaccini 1,*
Irem Unalan 1, Stefan J. Endlein 1, Benedikt Slavik 2, Andrea Buettner 2, Wolfgang H. Goldmann 3, Rainer Detsch 1 and Aldo R. Boccaccini 1,*
1
Institute of Biomaterials, Department of Materials Science and Engineering, Friedrich-Alexander-University Erlangen-Nuremberg, Cauerstraße 6, 91058 Erlangen, Germany
2
Chair of Aroma and Smell Research, Department of Chemistry and Pharmacy, Friedrich-Alexander-University Erlangen-Nuremberg, Henkestraße 9, 91054 Erlangen, Germany
3
Institute of Biophysics, Department of Physics, Friedrich-Alexander-University Erlangen-Nuremberg, Henkestraße 91, 91052 Erlangen, Germany
*
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(11), 570; https://doi.org/10.3390/pharmaceutics11110570
Received: 16 October 2019 / Revised: 30 October 2019 / Accepted: 30 October 2019 / Published: 1 November 2019
(This article belongs to the Special Issue Recent Development of Electrospinning for Drug Delivery)
The objective of this study was to produce antibacterial poly(ε-caprolactone) (PCL)-gelatin (GEL) electrospun nanofiber mats containing clove essential oil (CLV) using glacial acetic acid (GAA) as a “benign” (non-toxic) solvent. The addition of CLV increased the fiber diameter from 241 ± 96 to 305 ± 82 nm. Aside from this, the wettability of PCL-GEL nanofiber mats was increased by the addition of CLV. Fourier-transform infrared spectroscopy (FTIR) analysis confirmed the presence of CLV, and the actual content of CLV was determined by gas chromatography–mass spectrometry (GC-MS). Our investigations showed that CLV-loaded PCL-GEL nanofiber mats did not have cytotoxic effects on normal human dermal fibroblast (NHDF) cells. On the other hand, the fibers exhibited antibacterial activity against Staphylococcus aureus and Escherichia coli. Consequently, PCL-GEL/CLV nanofiber mats are potential candidates for antibiotic-free wound healing applications.
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Keywords:
electrospinning; PCL; gelatin; clove essential oil; antibacterial; biocompatibility
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Unalan, I.; Endlein, S.J.; Slavik, B.; Buettner, A.; Goldmann, W.H.; Detsch, R.; Boccaccini, A.R. Evaluation of Electrospun Poly(ε-Caprolactone)/Gelatin Nanofiber Mats Containing Clove Essential Oil for Antibacterial Wound Dressing. Pharmaceutics 2019, 11, 570.
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