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Drug Delivery Applications of Core-Sheath Nanofibers Prepared by Coaxial Electrospinning: A Review

1
Department of Chemistry, Inha University, 100 Inharo, Incheon 402-751, Korea
2
Department of Bioenvironmental Chemistry, College of Agriculture & Life Science, Chonbuk National University, Jeonju 561-756, Korea
*
Authors to whom correspondence should be addressed.
Pharmaceutics 2019, 11(7), 305; https://doi.org/10.3390/pharmaceutics11070305
Received: 22 May 2019 / Revised: 27 June 2019 / Accepted: 28 June 2019 / Published: 1 July 2019
(This article belongs to the Special Issue Recent Development of Electrospinning for Drug Delivery)
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PDF [1637 KB, uploaded 1 July 2019]
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Abstract

Electrospinning has emerged as one of the potential techniques for producing nanofibers. The use of electrospun nanofibers in drug delivery has increased rapidly over recent years due to their valuable properties, which include a large surface area, high porosity, small pore size, superior mechanical properties, and ease of surface modification. A drug loaded nanofiber membrane can be prepared via electrospinning using a model drug and polymer solution; however, the release of the drug from the nanofiber membrane in a safe and controlled way is challenging as a result of the initial burst release. Employing a core-sheath design provides a promising solution for controlling the initial burst release. Numerous studies have reported on the preparation of core-sheath nanofibers by coaxial electrospinning for drug delivery applications. This paper summarizes the physical phenomena, the effects of various parameters in coaxial electrospinning, and the usefulness of core-sheath nanofibers in drug delivery. Furthermore, this report also highlights the future challenges involved in utilizing core-sheath nanofibers for drug delivery applications. View Full-Text
Keywords: electrospinning; coaxial spinning; core-sheath nanofibers; biomedical; drug delivery electrospinning; coaxial spinning; core-sheath nanofibers; biomedical; drug delivery
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Pant, B.; Park, M.; Park, S.-J. Drug Delivery Applications of Core-Sheath Nanofibers Prepared by Coaxial Electrospinning: A Review. Pharmaceutics 2019, 11, 305.

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