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Open AccessArticle

Preformulation Study of Electrospun Haemanthamine-Loaded Amphiphilic Nanofibers Intended for a Solid Template for Self-Assembled Liposomes

1
Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen, Hue City 530000, Viet Nam
2
Institute of Pharmacy, Faculty of Medicine, University of Tartu, Nooruse str. 1, 54011 Tartu, Estonia
*
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(10), 499; https://doi.org/10.3390/pharmaceutics11100499
Received: 31 August 2019 / Revised: 26 September 2019 / Accepted: 27 September 2019 / Published: 29 September 2019
(This article belongs to the Special Issue Recent Development of Electrospinning for Drug Delivery)
Haemanthamine (HAE) has been proven as a potential anticancer agent. However, the therapeutic use of this plant-origin alkaloid to date is limited due to the chemical instability and poorly water-soluble characteristics of the agent. To overcome these challenges, we developed novel amphiphilic electrospun nanofibers (NFs) loaded with HAE, phosphatidylcholine (PC) and polyvinylpyrrolidone (PVP), and intended for a stabilizing platform (template) of self-assembled liposomes of the active agent. The NFs were fabricated with a solvent-based electrospinning method. The chemical structure of HAE and the geometric properties, molecular interactions and physical solid-state properties of the NFs were investigated using nuclear magnetic resonance (NMR) spectroscopy, scanning electron microscopy (SEM), photon correlation spectroscopy (PCS), Fourier transform infrared (FTIR) spectroscopy, X-ray powder diffraction (XRPD) and differential scanning calorimetry (DSC), respectively. An in-house dialysis-based dissolution method was used to investigate the drug release in vitro. The HAE-loaded fibers showed a nanoscale size ranging from 197 nm to 534 nm. The liposomes with a diameter between 63 nm and 401 nm were spontaneously formed as the NFs were exposed to water. HAE dispersed inside liposomes showed a tri-modal dissolution behavior. In conclusion, the present amphiphilic NFs loaded with HAE are an alternative approach for the formulation of a liposomal drug delivery system and stabilization of the liposomes of the present alkaloid. View Full-Text
Keywords: haemanthamine; plant-origin alkaloid; electrospinning; amphiphilic nanofibers; self-assembled liposomes; physical solid-state properties; drug release haemanthamine; plant-origin alkaloid; electrospinning; amphiphilic nanofibers; self-assembled liposomes; physical solid-state properties; drug release
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MDPI and ACS Style

Viet Nguyen, K.; Laidmäe, I.; Kogermann, K.; Lust, A.; Meos, A.; Viet Ho, D.; Raal, A.; Heinämäki, J.; Thi Nguyen, H. Preformulation Study of Electrospun Haemanthamine-Loaded Amphiphilic Nanofibers Intended for a Solid Template for Self-Assembled Liposomes. Pharmaceutics 2019, 11, 499.

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