Advanced Drug Delivery across the Blood–Brain Barrier

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 2906

Special Issue Editors


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Guest Editor
Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri, Kansas City, MO 64108, USA
Interests: drug delivery; peptide therapeutics; nucleic acid therapeutics; cancer therapy; immunotherapy; nanotechnology; formulation

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Guest Editor
Institute of Biophysics, School of Health Science and Biomedical Engineering, Hebei University of Technology, No. 5340 Xipin Street, Tianjin 050018, China
Interests: drug delivery; functional peptide; therapeutics; siRNA therapeutics; CNS therapy; cancer therapy; autoimmune disease therapy; nanotechnology

Special Issue Information

Dear Colleagues,

Delivering therapeutic agents across the blood–brain barrier (BBB) remains a significant challenge in the treatment of neurological diseases. The BBB, composed of tightly packed endothelial cells, restricts the passage of most therapeutic agents into the central nervous system. Thus, overcoming this barrier is essential for the effective treatment of neurological disorders.

This Special Issue aims to highlight recent advancements in drug delivery strategies that cross the BBB. By elucidating the mechanisms behind successful delivery strategies and reporting on innovative approaches, we seek to advance our understanding and capabilities in this crucial area of drug delivery.

Contributions featuring innovative technologies, targeted delivery systems, new applications in various diseases, and insights into BBB physiology are strongly encouraged. Through collaborative efforts and interdisciplinary dialogue, this Special Issue seeks to stimulate advancements in drug delivery across the BBB and pave the way for enhanced treatments for neurological diseases.

Prof. Dr. Kun Cheng
Dr. Zhen Zhao
Guest Editors

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Keywords

  • blood–brain barrier (BBB)
  • central nervous system (CNS)
  • drug delivery
  • neurological disease
  • nanotechnology
  • transport mechanism
  • targeted delivery
  • BBB permeability
  • glioblastoma

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Published Papers (1 paper)

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Review

32 pages, 1270 KiB  
Review
Drug Delivery Across the Blood–Brain Barrier: A New Strategy for the Treatment of Neurological Diseases
by Yimai Jiao, Luosen Yang, Rujuan Wang, Guoqiang Song, Jingxuan Fu, Jinping Wang, Na Gao and Hui Wang
Pharmaceutics 2024, 16(12), 1611; https://doi.org/10.3390/pharmaceutics16121611 - 19 Dec 2024
Cited by 2 | Viewed by 2136
Abstract
The blood–brain barrier (BBB) serves as a highly selective barrier between the blood and the central nervous system (CNS), and its main function is to protect the brain from foreign substances. This physiological property plays a crucial role in maintaining CNS homeostasis, but [...] Read more.
The blood–brain barrier (BBB) serves as a highly selective barrier between the blood and the central nervous system (CNS), and its main function is to protect the brain from foreign substances. This physiological property plays a crucial role in maintaining CNS homeostasis, but at the same time greatly limits the delivery of drug molecules to the CNS, thus posing a major challenge for the treatment of neurological diseases. Given that the high incidence and low cure rate of neurological diseases have become a global public health problem, the development of effective BBB penetration technologies is important for enhancing the efficiency of CNS drug delivery, reducing systemic toxicity, and improving the therapeutic outcomes of neurological diseases. This review describes the physiological and pathological properties of the BBB, as well as the current challenges of trans-BBB drug delivery, detailing the structural basis of the BBB and its role in CNS protection. Secondly, this paper reviews the drug delivery strategies for the BBB in recent years, including physical, biological and chemical approaches, as well as nanoparticle-based delivery technologies, and provides a comprehensive assessment of the effectiveness, advantages and limitations of these delivery strategies. It is hoped that the review in this paper will provide valuable references and inspiration for future researchers in therapeutic studies of neurological diseases. Full article
(This article belongs to the Special Issue Advanced Drug Delivery across the Blood–Brain Barrier)
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