Drug Delivery Across or Bypassing the Blood–Brain Barrier

Dear Colleagues,

The blood–brain barrier (BBB), the blood–central-system–fluid barrier, and the blood–tumor barrier are major hurdles for treating central nervous system (CNS) diseases of the brain and spine as they limit the passage of most therapeutic agents from the blood into CNS tissues. Currently, there is no standard treatment approach for penetrating/bypassing these barriers. Increasing worldwide lifespan has led to a rise in the prevalence of neurodegenerative disorders, having a huge impact on society and the economy. However, the majority of currently available treatments are ineffective due to low or no penetration of most therapeutic agents across the BBB. Thus, means to bypass these barriers or transiently disrupt them in a safe and controlled manner are in desperate need. This Special Issue summarizes the most recent advances made in the field of therapeutic agent delivery into the CNS.

Prof. Dr. Yael Mardor
Dr. Shirley Sharabi
Guest Editors

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