Carbohydrate-Based Drugs
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".
Deadline for manuscript submissions: closed (15 October 2022) | Viewed by 59139
Special Issue Editors
Interests: NO-donor; prodrug strategy; molecular hybrid design; drug design; drug delivery; drug targeting
Special Issues, Collections and Topics in MDPI journals
Interests: prodrug strategy; carbohydrate-based prodrugs; drug targeting; drug discovery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Carbohydrates are one of the four major classes of biomolecules; they play important roles in various biological processes, including inflammation and immune response, angiogenesis and metastasis of cancer cells, viral and bacterial infections, and many other cell–cell communications. The tremendous effort made by glycoscientists in recent decades have allowed carbohydrate-based drugs to pave the way for an anonymous area of the therapeutic world.
Medicinal chemists use carbohydrates, particularly mono- and disaccharides, as valuable carriers or key substructures in order to improve the pharmaceutical phase, pharmacokinetics and pharmacodynamics of well-known drugs. Resorting to the prodrug strategy or multitarget drugs, the conjugation of a traditional drug to carbohydrates allows many limitations of the parent drug to be overcome, such as lack of site of action specificity, toxicity, chemical instability. Additionally, carbohydrate-based nanosystems have been shown to better deliver the starting drug or generate selective targeting towards specific body districts, as well as improve the cellular permeability and toxicological profile of the parent drug.
In this Special Issue, "Carbohydrate-Based Drugs", we aim to collect both original articles and up-to-date reviews that focus on the design, synthesis and biological evaluations of novel carbohydrate-based drugs, with a focus on carbohydrate-based prodrugs and nanosystems.
As Guest Editors, we encourage researchers working in this area to contribute their recent studies to this Special Issue of Pharmaceuticals.
Dr. Federica Sodano
Dr. Maria Grazia Rimoli
Guest Editors
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Keywords
- carbohydrates
- carbohydrate hybrids
- nanosystems
- carbohydrate-based polymers
- prodrugs
- anti-inflammatory activity
- antimicrobial activity
- anticancer activity
- pharmacokinetics profile
- drug targeting
- toxicity
- biomedical applications
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