Special Issue "Nano Drug Carriers"
A special issue of Pharmaceuticals (ISSN 1424-8247).
Deadline for manuscript submissions: closed (30 September 2018).
Interests: functional liposomes; functional dendritic polymers; nano-sized drug delivery systems; drug targeting; triggered drug release
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Since the introduction of the “magic bullet” concept by Paul Ehrlich in 1900, medicinal research has focused on developing pharmaceuticals that have the property of being directed towards specific targets of the body so as to increase therapeutic outcome and/or reduce side effects. From the early days, it was realized that the route of administration can yield different therapeutic results, initiating research on drug delivery. Drug delivery systems have therefore been introduced as a means to control drug biodistribution and reduce non-specific localization. The concept of drug carriers that can encapsulate a bioactive compound, increasing its solubility and its physicochemical stability, evade the attack of the immune system, finally find the target and release their payload in a controlled fashion, had limited success in the past but was largely reinvigorated with the advent of nanotechnology. Nano-sized drug delivery systems have been widely studied during the last three decades, engaging scientists of very different backgrounds, from chemists and material scientists to biologists and medical doctors. The renewed optimism in the field brought about by the introduction of nanoscience and nanotechnology in medicine, gave rise to the pursuit of additional goals such as triggered release, enhanced cell membrane permeation and, even, subcellular targeting. To date, more than fifty nanotherapeutics/nanoformulations have been approved, primarily based on liposomes, polymeric micelles or PEGylated peptides/proteins, and even more are currently under clinical investigation. One may argue that, despite great research efforts, relatively few systems are currently on the market, but this will change due to ongoing research, exploring new ways to evade the immune system, and identifying and targeting new cell receptors related to diseases. Further advances are anticipated by the use of appropriate mathematical modeling and computer science, including artificial neural networks, that are emerging to facilitate further understanding of the complex processes related to drug delivery.
In this Special Issue of Pharmaceuticals, both research, mini-review and review articles advancing our knowledge on nano-sized drug delivery systems are invited. Topics include, but are not limited to, theoretical and experimental research on the synthesis and development of nanocarriers or nanoformulations, their physicochemical and biological characterization, nanoparticle interaction with the immune system, computational modeling of nanoparticle drug delivery, in vitro and in vivo studies, preclinical and clinical studies, as well as safety issues regarding their production, handling and disposal.Dr. Dimitris Tsiourvas
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- nano-sized systems
- drug encapsulation
- drug targeting
- controlled release
- triggered release