Enzyme Inhibitors: Potential Therapeutic Approaches
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (25 October 2024) | Viewed by 25134
Special Issue Editor
Interests: medicinal chemistry; enzymology; biochemistry; COX inhibitors; LOX inhibitors; HIV-1 RT inhibitors; HIV-1 integrase inhibitors; PTP1b inhibitors; HIV-1 protease inhibitors; anti-inflammatory; antidiabetic; antiviral; antibacterial; antifungal; food-derived antigens; anti-Neu5Gc
Special Issue Information
Dear Colleagues,
Enzymes are involved in all biochemical processes; thus, they constitute the second greatest drug target after receptors. The dysregulation of enzyme activity has been related to several pathologic disorders. Apart from specific cases which demand enzyme administration to counteract the lack or reduced action of an enzyme, small molecules that moderate enzyme activity are broadly used. However, the enhancement of enzyme expression or activity is the aim in only certain cases, while enzyme inhibition is the most common drug target. Inhibitors of human enzymes are used to fight many common disorders, such as inflammation, hypertension and hypercholesterolemia, and are one of the medications for the treatment of diabetes. Moreover, most antiviral, antibacterial and antifungal agents also act as enzyme inhibitors. Despite approximately 790 enzyme inhibitors having been approved since 2021, the search for novel inhibitors for known enzyme drug targets continues, targeting the development of novel agents with improved properties, less side effects and ones appropriate for resistant strains. In addition, novel enzymes are added each year to the catalogue of drug targets for the anticipation of untreated diseases. Among the fourteen drugs for novel drug targets approved in 2021, four were enzymes and three of the approved drugs were enzyme inhibitors.
This Special Issue aims to gather research and review articles on enzymes and enzyme inhibitors with pharmaceutical interest, covering a hot and developing area of medical research.
Dr. Phaedra Eleftheriou
Guest Editor
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Keywords
- enzyme inhibitors
- drug targets
- therapeutic approaches
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