Novel Fluorescent Probes for Drug Discovery and Development

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 2239

Special Issue Editor


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Guest Editor
School of Life Science, Nanjing University, Nanjing 210093, China
Interests: design, evolution and application of fluorescence tools; assembly and application of fluorescent materials; computer-aided drug design
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Special Issue Information

Dear Colleagues,

The recent progress made in the field of fluorescent probes has led to a diverse range of novel functions in practical applications. Based on their specific optical properties, convenience, and biocompatibility, fluorescent probes have been utilized in the dynamic monitoring of molecular indexes as well as the biological imaging of physiological and pathological procedures. Notably, during the discovery and development of drugs or drug-like candidates, the mentioned indexes and image-guided information seem essential. Accordingly, novel fluorescent probes may directly participate in the composition of prodrugs with beneficial attributes, including real-time tracing or controlled release; they may also indirectly detect diagnostic or correlated parameters to monitor or visualize micro-environmental fluctuations under the affect of drugs. This Special Issue, entitled “Novel Fluorescent Probes for Drug Discovery and Development”, will describe the trials of developing novel fluorescent implements to contribute to the exploitation and promotion of drugs. The editor of this topic encourages the submission of research and review papers that cover both the applicable designs and practical utilization of these probes. We believe that interdisciplinary investigations in chemical biology and pharmaceutical chemistry can open the mind and inspire valuable further research, starting with your high-quality contribution to this issue.

Dr. Yu-Shun Yang
Guest Editor

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Keywords

  • fluorescent probes
  • drug design
  • drug development
  • novel fluorescent implements
  • fluorescent imaging

Published Papers (1 paper)

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Research

9 pages, 3413 KiB  
Article
A New Pyrroloquinoline-Derivative-Based Fluorescent Probe for the Selective Detection and Cell Imaging of Lysine
by Bing Yang, Jiahua Zhou, Xu Huang, Zhongping Chen, Shu Tian and Yujun Shi
Pharmaceuticals 2022, 15(4), 474; https://doi.org/10.3390/ph15040474 - 13 Apr 2022
Cited by 6 | Viewed by 1680
Abstract
In this paper, a new pyrroloquinoline-derivative-based fluorescent probe, PQP-1, was prepared for the selective detection of Lys in living cells and natural mineral water for drinking. PQP-1 exhibited high selectivity, low limit of detection, and a wide pH range. PQP-1 could be [...] Read more.
In this paper, a new pyrroloquinoline-derivative-based fluorescent probe, PQP-1, was prepared for the selective detection of Lys in living cells and natural mineral water for drinking. PQP-1 exhibited high selectivity, low limit of detection, and a wide pH range. PQP-1 could be successfully applied for imaging Lys in living cells and in natural mineral water for drinking. We expect that PQP-1 will expand the detection reaction mechanism and the practical biological applications of Lys. Full article
(This article belongs to the Special Issue Novel Fluorescent Probes for Drug Discovery and Development)
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