Therapeutic Potential of Bee Products

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: closed (22 December 2024) | Viewed by 1977

Special Issue Editors


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Guest Editor
1. Apitherapy Medical Center, Bălănești, Nr. 297, 217036 Gorj, România
2. Nutrition and Dietetics Specialization, Faculty of Pharmacy, Vasile Goldis Western University of Arad, 310025 Arad, Romania
Interests: antiviral effect; anti-tumor; fertility-stimulating; cardiac protector of bee products and some apitherapeutic formulations

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Guest Editor
“Cristofor Simionescu” Faculty of Chemical Engineering and Environment Protection, “Gheorghe Asachi” Technical University, Iasi, Romania
Interests: polysaccharide modification; bioactive polymers; biomaterials; hydrogels; interpenetrated networks; micro- and nanoparticles (spheres and capsules); hybrid and functionalized nanoparticles for drug targeting; drug delivery; polymer–drug conjugates
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Guest Editor
Department of Pharmaceutical Sciences, Faculty of Pharmacy, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Str., 700115 Iasi, Romania
Interests: cutaneous drug delivery; oral modified drug delivery systems; matrix solid dosage forms, nanoparticles as drug delivery systems; cosmetics and dermatocosmetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bee products or apitherapies have been used since ancient times in order to cure various diseases. The subject has also been addressed by both basic and clinical research, as bee products/apitherapies present a great diversity of compounds that influence biological properties and bioavailability. However, this area of great interest for human health has not been sufficiently explored to date.

Bee products (honey, pollen, herbs, propolis, royal jelly, apilarnil, etc.) are biocompatible, being themselves of natural origin. They contain polyphenols, vitamins, minerals, enzymes, hormones, esters, carbonyls, lipids, etc., which can modulate antioxidant, antiviral, epithelialising, bactericidal, immunostimulating, regenerative, hepatoprotective, neuroprotective and cardioprotective effects or may intervene in haematological, gynaecological, infertility–sterility orother types of oncological disorders.

This Special Issue aims to present the following:

  1. the most recent fundamental research on the administration of apiculture products or in various formulations;
  2. clinical research on the administration of apitherapies in various pathologies;
  3. literature reviews on the effect of apiculture products on various systems and mechanisms of the human body;
  4. presentation of the most recent research on the development of polymeric systems for the inclusion, transport and release of apitherapy compounds (hydrogels, nanoparticles/nanocapsules, liposomes, etc.) at the level of the cell membranes of various organs.

Dr. Călin Vasile Andriţoiu
Prof. Dr. Marcel Popa
Prof. Dr. Lacramioara Ochiuz
Guest Editors

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Keywords

  • Apitherapy
  • bee products
  • honey
  • polen
  • apilarnil
  • Royal Jelly
  • polymer delivery system of apitherapy products

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Published Papers (1 paper)

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Research

20 pages, 64752 KiB  
Article
In Vivo Assessment of Healing Potential of Ointments Containing Bee Products, Vegetal Extracts, and Polymers on Skin Lesions
by Calin Vasile Andritoiu, Cristina Lungu, Camelia Elena Iurciuc (Tincu), Corina Elena Andriescu, Corneliu Havarneanu, Marcel Popa, Magdalena Cuciureanu, Liliana Mititelu Tarţău and Bianca Ivanescu
Pharmaceuticals 2025, 18(1), 65; https://doi.org/10.3390/ph18010065 - 9 Jan 2025
Viewed by 730
Abstract
Background/Objectives: The present experiment aimed to formulate four ointments that included mixtures of plant extracts (Hippophae rhamnoides, Calendula officinalis, Arctium lappa, and Achillea millefolium), apitherapy products (honey, propolis, and apilarnil) and natural polymers (collagen, chitosan, and the lyophilisate [...] Read more.
Background/Objectives: The present experiment aimed to formulate four ointments that included mixtures of plant extracts (Hippophae rhamnoides, Calendula officinalis, Arctium lappa, and Achillea millefolium), apitherapy products (honey, propolis, and apilarnil) and natural polymers (collagen, chitosan, and the lyophilisate of egg white) in an ointment base. Methods: In order to investigate the therapeutic properties of the ointments, experimental in vivo injury models (linear incision, circular excision, and thermal burns) were performed on laboratory animals, namely Wistar rats. The treatment was applied topically, once a day, for 21 days. Clinical and macroscopic evaluation, determination of lesion shrinkage rate, re-epithelialization period, and histopathological examination were performed. Results: The results demonstrate that the tested ointments have a significant effect in healing skin lesions. On the ninth day of treatment, the wound contraction rate was 98.17 ± 0.15% for the mixed ointment group, compared to the negative control group’s rate of 14.85 ± 2.95%. At day 21, dermal collagenization and restoration of histological structure occurred for all treated groups. Conclusions: The tested ointments exerted in vivo wound healing and re-epithelialization effects on incision, excision, and thermal burn injuries. Full article
(This article belongs to the Special Issue Therapeutic Potential of Bee Products)
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