SARS-CoV Infections

Dear Colleagues,

SARS Coronavirus (CoV) caused the first epidemic of the 21^st century. The zoonotic emergence of SARS-CoV highlights the risk of rapid global spread of a highly infectious, novel pathogen. Disease ranged from mild respiratory symptoms to development of acute respiratory distress syndrome (ARDS) and death; ultimately the virus infected over 8,000 people with a 10% mortality rate. While SARS-CoV was contained by effective public health measures, a number of highly related zoonotic viruses have been found in bats that are fully capable of infecting human cells.

In the 16 years since SARS-CoV was identified, much has been learned about its emergence, replication and resulting disease. Several reverse genetics systems have allowed for investigation of the role of viral genes in both in vitro and in vivo infections while development of small animal models has allowed examination of the role of the host immune response following infection. Recent advances in structural biology have provided critical insights into how the viral spike protein binds to its cellular receptor, Ace2.

We would like to invite you to contribute to a Topical Collection on SARS-CoV Infections. In this Special Issue we welcome the coronavirus community to submit a research article, review or short communication focused on SARS-CoV emergence, replication, disease pathogenesis and protection, host immune response modulation, structural insights or anti-viral therapeutics.

We look forward to your contribution.

Dr. Lisa Gralinski
Collection Editor

Circulating bat viruses and emerging coronaviruses, recent structure advances, reverse genetics systems, immune mediated disease, 1^st epidemic of 21^st century

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