Current Challenge and Future Advances for Lung Cancer: Genetics, Instrumental Diagnosis and Treatment 2.0

A special issue of Onco (ISSN 2673-7523).

Deadline for manuscript submissions: closed (15 August 2024) | Viewed by 2998

Special Issue Editor


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Guest Editor
Thoracic Surgery Unit, University of Campania Luigi Vanvitelli, I-80138 Naples, Italy
Interests: lung cancer; diagnosis; treatment; therapy; surrogate biomarkers; preclinical and translational research
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the second edition of the previous Special Issue entitled the "Current Challenge and Future Advances for Lung Cancer: Genetics, Instrumental Diagnosis and Treatment"
(https://www.mdpi.com/journal/cancers/special_issues/Lung_Cancer_Genetics_Instrumental_Diagnosis_Treatment).

Lung cancer remains a malignancy with a poor prognosis, with only 20% of patients reporting an overall survival rate longer than five years from diagnosis. The prognosis of these patients has not significantly improved, despite the developments in the definition of the genetic evolution of lung cancer, the greater accuracy of diagnostic procedures, and the refinement of treatments using multimodal regimens, including surgery, radiotherapy, and systemic therapy (chemotherapy, immunotherapy, and targeted therapy).

Therefore, this Special Issue will include data on potential new diagnostic and therapeutic discoveries that aim to improve the prognosis of lung cancer patients. In particular, the most recent acquisitions regarding the biology of lung cancer (both non-small- and small-cell lung cancer), such as specific gene mutations, genomic heterogeneity, and the discovery of new biomarkers, will be highlighted.

Furthermore, we welcome papers that cover the following topics: (1) developments in diagnostic methods for the early diagnosis of lung cancer, including radiological studies; (2) studies or reviews on innovative aspects of lung cancer treatment in the fields of surgery, radiotherapy, and medical treatments; and (3) studies on real life experiences of multimodal approaches.

Ultimately, for this Special Issue, we welcome basic translational and clinical research papers, studies on cancer biomarkers, professional opinions, and reviews in the broad field of lung cancer diagnosis and therapy in the following categories:

  • Lung cancer diagnosis.
  • Lung cancer metastases (with an emphasis on CNS metastases).
  • Lung cancer surgery.
  • Lung cancer radiotherapy.
  • Lung cancer chemotherapy.
  • Lung cancer target therapies.
  • Lung cancer immunotherapy.
  • Elderly populations with lung cancer.
  • Side effects of lung cancer therapies.
  • Surrogate biomarkers in lung cancer.
  • Preclinical and translational research in lung cancer.

Dr. Giovanni Vicidomini
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Onco is an international peer-reviewed open access quarterly journal published by MDPI.

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Keywords

  • lung cancer
  • diagnosis
  • treatment
  • therapy
  • cancer metastases (with an emphasis on CNS metastases)
  • surgery
  • radiotherapy
  • chemotherapy
  • target therapies
  • immunotherapy
  • elderly with lung cancer
  • side effects
  • surrogate biomarkers
  • preclinical research
  • translational research

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Published Papers (1 paper)

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Review

16 pages, 499 KiB  
Review
ROS1-Rearranged Lung Adenocarcinoma: From Molecular Genetics to Target Therapy
by Ugo Testa, Germana Castelli and Elvira Pelosi
Onco 2023, 3(3), 189-204; https://doi.org/10.3390/onco3030014 - 22 Aug 2023
Cited by 1 | Viewed by 2163
Abstract
Non-small-cell lung cancer (NSCLC) is a heterogeneous group of diseases accounting for 80–85% of lung cancers. A molecular subset of NSCLC (1–2.5%) harboring molecular rearrangements of the tyrosine kinase gene ROS1 is defined as ROS1-positive and is almost exclusively diagnosed in patients with [...] Read more.
Non-small-cell lung cancer (NSCLC) is a heterogeneous group of diseases accounting for 80–85% of lung cancers. A molecular subset of NSCLC (1–2.5%) harboring molecular rearrangements of the tyrosine kinase gene ROS1 is defined as ROS1-positive and is almost exclusively diagnosed in patients with lung adenocarcinoma histology, predominantly nonsmokers. ROS1 is constitutively activated by molecular rearrangements and acts as a main driver of lung carcinogenesis. These findings have provided a strong rationale for the clinical use of tyrosine kinase inhibitors that target ROS1; these inhibitors block ROS1-positive NSCLC and provide clinical benefit. Crizotinib was introduced as a first-line treatment for ROS1-positive NSCLCs, with 75–80% of patients responding and a PFS of about 20 months. More recently developed ROS1-TKIs, such as entrectinib, lorlatinib, taletrectinib, repotrectinib and NVL-520, are active against some resistant ROS1 mutants appearing during crizotinib therapy and more active against brain metastases, frequent in ROS1-positive NSCLC. The development of resistance mechanisms represents a great limitation for the targeted treatment of ROS1-positive NSCLCs with TKIs. Full article
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