Special Issue "Vitamin K in Human Health and Disease"
A special issue of Nutrients (ISSN 2072-6643).
Deadline for manuscript submissions: closed (31 July 2018).
Interests: nutrition; vitamin K metabolism; ageing; brain function; Alzheimer’s disease; cardiovascular disease; nutrition interventions; nutrition requirements
Interests: vitamin K; vitamin K reductases; protein gamma-carboxylation; bone metabolism; glucose metabolism; insulin secretion; insulin sensitivity
Initially discovered for its role in blood coagulation, it is now recognized that vitamin K (VK) is involved in many physiological systems besides hemostasis. Furthermore, it is now emerging that VK has biological and clinical roles that extend beyond its well-characterized action as an enzyme cofactor for the carboxylation of the VK-dependent proteins (VKDP). The aim of this Special Issue, entitled “Vitamin K in Human Health and Disease”, is to share the latest research findings on topics, such as (but not exclusively) the molecular aspects of VK cycle and metabolism (i.e., VKORC1, VKORC1L1), the VKDP as regards their emerging roles in energy metabolism and endocrine function (i.e., osteocalcin), the calcification process (i.e., matrix Gla protein) and brain function (i.e., Gas6), and the non-enzymatic role of menaquinone-4 (MK-4). These basic aspects of VK functions and metabolism will be discussed in the context of various chronic diseases, i.e., diabetes, CVD, CKD, cognitive impairment, and considering the modulatory role of VK nutritional status.
Prof. Dr. Guylaine Ferland
Dr. Mathieu Ferron
Manuscript Submission Information
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- Vitamin K (VK)
- Menaquinone-4 (MK-4)
- VKOR (VKORC1, VKORC1L1)
- Vitamin K-dependent proteins (VKDP)
- Matrix Gla protein
- Calcification process
- Endocrine function
- Energy metabolism
- Cardiovascular disease (CVD)
- Chronic kidney disease (CKD)
- Brain function