Special Issue "Nutrition in Cognitive Impairment, Dementia, and Alzheimer's Disease"
Deadline for manuscript submissions: closed (31 December 2020).
Interests: brain aging; MCI; neuroinflammation; brain–gut interaction; neurovascular unit; human interventional study; RCT; psychometoric tests; MRI; surrogate markers; epidemiological study; functional peptides; polyphenols; Alzheimer’s disease model mice
Dementia is a major global health issue, since more than 10% of the elder population (>65 years old) is diagnosed with the syndrome in most of the recent epidemiologic studies. By 2050, more than 130 million people are estimated to have dementia worldwide. Alzheimer’s disease (AD) is the most frequent cause of dementia. Mild cognitive impairment (MCI) is an intermediate transitional stage between the cognitive normal and dementia. In AD, the accumulation of cerebral amyloid-beta has usually been occurring for more than 20 years before the onset of dementia. At the dementia stage, neuronal damage progresses together with the accumulation of tau protein. The necessity of targeting MCI or preclinical AD in clinical trials to prevent dementia is now widely recognized; however, no evidence of pharmacological treatments or cognitive training for preventing the development of dementia has been demonstrated. Under these circumstances, supplementation of food-derived materials attracts attention as potentially beneficial for reducing risks, and further research is needed. Nutritional substances present in food, such as functional peptides like imidazoledipeptides, polyphenols, and PFAs (DHA and EPA), have a potential protective effect on cognitive functions. On this topic, you are invited to submit proposals for manuscripts that fit the objectives and the topics of this Special Issue.
The objective of this proposed Special Issue on “Nutrition in Cognitive Impairment, Dementia, and Alzheimer's Disease” is to publish selected papers detailing specific aspects of nutrition that could play a role in protecting cognitive declines, both in normal elderly subjects, MCI, and in patients with dementia. Particularly, papers (reviews and/or clinical or experimental studies) dealing with the role of specific nutrients on cognitive function, and also contributions addressing their indirect effects through brain–gut interaction will be included.
Dr. Tatsuhiro Hisatsune
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Brain aging
- Brain–gut interaction
- Neurovascular unit
- Human interventional study
- Alzheimer’s disease
- Clinical trials
- Cognitive impairment
- Diet/dietary patterns
- Functional peptides
- Observational studies