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Neuroprotective Effects of Choline and Other Methyl Donors

Department of Biological Sciences, Rutgers University, Newark, NJ 07102, USA
Nutrients 2019, 11(12), 2995; https://doi.org/10.3390/nu11122995
Received: 6 November 2019 / Revised: 20 November 2019 / Accepted: 5 December 2019 / Published: 6 December 2019
(This article belongs to the Special Issue Nutrition in Cognitive Impairment, Dementia, and Alzheimer's Disease)
Recent evidence suggests that physical and mental health are influenced by an intricate interaction between genes and environment. Environmental factors have been shown to modulate neuronal gene expression and function by epigenetic mechanisms. Exposure to these factors including nutrients during sensitive periods of life could program brain development and have long-lasting effects on mental health. Studies have shown that early nutritional intervention that includes methyl-donors improves cognitive functions throughout life. Choline is a micronutrient and a methyl donor that is required for normal brain growth and development. It plays a pivotal role in maintaining structural and functional integrity of cellular membranes. It also regulates cholinergic signaling in the brain via the synthesis of acetylcholine. Via its metabolites, it participates in pathways that regulate methylation of genes related to memory and cognitive functions at different stages of development. Choline-related functions have been dysregulated in some neurodegenerative diseases suggesting choline role in influencing mental health across the lifespan. View Full-Text
Keywords: brain; choline; dementia; epigenetics; methyl-donors; nutrition; neuroprotection brain; choline; dementia; epigenetics; methyl-donors; nutrition; neuroprotection
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MDPI and ACS Style

Bekdash, R.A. Neuroprotective Effects of Choline and Other Methyl Donors. Nutrients 2019, 11, 2995. https://doi.org/10.3390/nu11122995

AMA Style

Bekdash RA. Neuroprotective Effects of Choline and Other Methyl Donors. Nutrients. 2019; 11(12):2995. https://doi.org/10.3390/nu11122995

Chicago/Turabian Style

Bekdash, Rola A. 2019. "Neuroprotective Effects of Choline and Other Methyl Donors" Nutrients 11, no. 12: 2995. https://doi.org/10.3390/nu11122995

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