Next Article in Journal
Natural Protein Tolerance and Metabolic Control in Patients with Hereditary Tyrosinaemia Type 1
Next Article in Special Issue
Vitamins in Alzheimer’s Disease—Review of the Latest Reports
Previous Article in Journal
Anserine Reverses Exercise-Induced Oxidative Stress and Preserves Cellular Homeostasis in Healthy Men
Previous Article in Special Issue
Influence of the Mediterranean and Ketogenic Diets on Cognitive Status and Decline: A Narrative Review
Open AccessArticle

The Different Relationship between Homocysteine and Uric Acid Levels with Respect to the MTHFR C677T Polymorphism According to Gender in Patients with Cognitive Impairment

by 1,*,†, 2,†, 1 and 2,*
1
Department of Neurology, Hanyang University, 222, Wansimni-ro, Seondong-gu, Seoul 04763, Korea
2
Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, 222-1, Wansimni-ro, Seondong-gu, Seoul 04763, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this study.
Nutrients 2020, 12(4), 1147; https://doi.org/10.3390/nu12041147
Received: 23 February 2020 / Revised: 15 April 2020 / Accepted: 16 April 2020 / Published: 19 April 2020
(This article belongs to the Special Issue Nutrition in Cognitive Impairment, Dementia, and Alzheimer's Disease)
In an elderly population with cognitive impairment, we investigated the association between serum uric acid (sUA) and serum homocysteine (sHcy), known risk factors for cerebrovascular disease. We also investigated the potential effect of the C677T polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR) to the sUA level in different dementia types. Participants underwent a battery of tests including measurements of sUA, sHcy, folic acid, and vitamin B12 as well as genotyping of the MTHFR locus. Data from 861 subjects (597 females to 264 males) were retrospectively analyzed. Subjects with hyperhomocysteinemia had lower serum folic acid and vitamin B12 and higher sUA than those with normal sHcy. sUA was significantly associated with serum creatinine, HbA1c, and sHcy regardless of gender. The TT genotype was found to be associated with hyperhomocysteinemia in both genders (p = 0.001). The levels of hyperlipidemia, sHcy, and sUA differed according to dementia subtypes. High sUA were associated with hyperhomocystenemia in TT genotype only in dementia with vascular lesion. This study reveals that sUA is positively associated with sHcy. We speculate that the two markers synergistically increase cerebrovascular burden and suggested that dietary intervention for sUA and sHcy would be helpful for cognitive decline with vascular lesion. View Full-Text
Keywords: methylenetetrahydrofolate reductase; homocysteine; uric acid; cognitive impairment; cerebrovascular disorder methylenetetrahydrofolate reductase; homocysteine; uric acid; cognitive impairment; cerebrovascular disorder
MDPI and ACS Style

Kim, H.-J.; Sohn, I.W.; Kim, Y.S.; Jun, J.-B. The Different Relationship between Homocysteine and Uric Acid Levels with Respect to the MTHFR C677T Polymorphism According to Gender in Patients with Cognitive Impairment. Nutrients 2020, 12, 1147. https://doi.org/10.3390/nu12041147

AMA Style

Kim H-J, Sohn IW, Kim YS, Jun J-B. The Different Relationship between Homocysteine and Uric Acid Levels with Respect to the MTHFR C677T Polymorphism According to Gender in Patients with Cognitive Impairment. Nutrients. 2020; 12(4):1147. https://doi.org/10.3390/nu12041147

Chicago/Turabian Style

Kim, Hee-Jin; Sohn, Il W.; Kim, Young S.; Jun, Jae-Bum. 2020. "The Different Relationship between Homocysteine and Uric Acid Levels with Respect to the MTHFR C677T Polymorphism According to Gender in Patients with Cognitive Impairment" Nutrients 12, no. 4: 1147. https://doi.org/10.3390/nu12041147

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop