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Special Issue "Biomarkers in HIV Associated Neurocognitive Disorders"
A special issue of Neurology International (ISSN 2035-8377).
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 317
Special Issue Editors
Interests: biochemistry; cardiovascular diseases; Neurodegenerative diseases; inflammatory bowel diseases; Liver Diseases; phytochemicals; and natural products
Interests: chitinases; innate immunity; osteoclasts; bone remodeling; monocytes; macrophages; chi3l1; chitotriosidase; bioinformatics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
The advent of antiretroviral therapy (ART) in the early 1990s and the continued development of antiretroviral (ARV) drugs has transformed HIV infection from an almost universally fatal infection to a chronic manageable disease for the majority of people living with HIV (PLWH). However, chronic low level viral infection, inflammation, immune activation, and unintended effects of long-term ART have resulted in frequent metabolic complications in PLWH on ART that include insulin resistance, lipodystrophy, dyslipidemia, increased rates of cardiovascular disease, liver disease, and impairments in some aspects of cognition. It is understood that HIV-1 enters the brain shortly after infection via infected monocytes and blood lymphocytes, which may establish a spectrum of HIV-associated neurocognitive disorders (HAND).
Milder to moderate forms of cognitive impairment and behavioral and motor dysfunctions are commonly seen in HAND in approximately 50 % of PLWH treated with ART. The underlying cause for these residual impairments in cognition remains unclear. Currently, the gold standard for diagnosing and monitoring the progression of cognitive function in HIV-infected patients is neurophysiological testing. Although these tests have been extremely valuable to diagnose and monitor cognitive status, neuropsychological measures can be cohort dependent and require appropriate sets of cultural norms in order to obtain an accurate picture of disease progression. These measures are also relatively insensitive to subtle changes in cognitive status and thus are not ideal surrogate measures for the effectiveness of therapeutics in clinical trials. HAND was reported to be associated with pathological changes in the brain that include generalized atrophy, leukoencephalopathy, viral encephalitis, multinucleated giant cells, neurofilament light chain concentration, amyloid and tau proteins, etc. Nevertheless, there is lack of profound and precise markers which are needed for an accurate diagnosis of HAND. This Special Issue is dedicated to presenting experimental data from current research and reviews on the discovery of biomarkers associated with HAND which will allow advancing our current understanding of HAND pathogenesis.
Dr. Pragney Deme
Dr. Michelino Di Rosa
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Neurology International is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- HIV infection
- Neurological disorders
- Cerebrospinal fluid biomarkers
- Neuroimaging biomarkers
- Plasma biomarkers
- Comorbid conditions (aging, cardiovascular disease, etc.)
- Coinfections (HCV)
- Omics (metabolomics, proteomics, and genomics)