Advances in Novel Treatment and Rehabilitation for Strokes

A special issue of Neurology International (ISSN 2035-8377). This special issue belongs to the section "Movement Disorders and Neurodegenerative Diseases".

Deadline for manuscript submissions: closed (31 January 2026) | Viewed by 7162

Special Issue Editors


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Guest Editor
Department of Physical Therapy, Faculty of Health Sciences, Tokyo Metropolitan University, Tokyo 116-8551, Japan
Interests: stroke

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Guest Editor
Department of Physical Therapy, Reiwa Health Sciences University, Hukuoka 811-0213, Japan
Interests: dysphagia; community-dwelling older people; oral function; stroke

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Guest Editor
Department Physical Therapy, Hiroshima Cosmopolitan University, Hiroshima, Japan
Interests: stroke; rehabilitation; illusion; action observation therapy; paralysis; unilateral spatial neglect

Special Issue Information

Dear Colleagues,

This Special Issue invites a wide range of studies describing and assessing novel rehabilitation strategies related to gait, higher-brain dysfunction, motor impairment, brain function, and dysphagia in patients who have had a stroke. Despite the advancements in stroke rehabilitation with the development of science and technology, older forms of rehabilitation assessment and treatment are still being used, with few proposals for new strategies which would change existing rehabilitation practices. This Special Issue focuses on rehabilitation assessment methods and treatments, as well as novel rehabilitation proposals.

Dr. Katsuya Sakai
Dr. Motoyoshi Morishita
Dr. Junpei Tanabe
Guest Editors

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Keywords

  • stroke
  • rehabilitation
  • therapy
  • assessments
  • gait
  • higher-brain dysfunction
  • motor function
  • brain function
  • dysphagia

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Published Papers (2 papers)

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Research

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9 pages, 231 KB  
Article
Very Early Rehabilitation After Treatment with Intravenous Thrombolysis for Mild Acute Ischemic Stroke
by Rahul R. Karamchandani, Liang Wang, Dale Strong, Alexis A. Mulvaney, Jonathan D. Clemente and Jeremy B. Rhoten
Neurol. Int. 2025, 17(4), 60; https://doi.org/10.3390/neurolint17040060 - 18 Apr 2025
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Abstract
Background/Objectives: The optimal timing of rehabilitation after acute ischemic stroke is unclear. We studied neurological outcomes and safety of early mobilization (EM) within 24 h for patients receiving intravenous thrombolysis. Methods: This was a retrospective analysis of patients treated at a single Comprehensive [...] Read more.
Background/Objectives: The optimal timing of rehabilitation after acute ischemic stroke is unclear. We studied neurological outcomes and safety of early mobilization (EM) within 24 h for patients receiving intravenous thrombolysis. Methods: This was a retrospective analysis of patients treated at a single Comprehensive Stroke Center from 6/2020–10/2024 with EM versus usual care. Patients were eligible for EM if they were treated with intravenous thrombolysis and had post-treatment National Institutes of Health Stroke Scale scores ≤ 5, and later, ≤10. Ordinal regression was performed to determine factors associated with a 90-day functional outcome benefit in the full cohort. Propensity scores were calculated for matched sample pairs to determine any shift towards better outcomes with EM. Results: Groups of 165 and 73 patients were treated with EM and usual care, respectively. Treatment with EM was not associated with improved 90-day neurological outcome (odds ratio [OR] for higher mRS 0.746, p = 0.265). The groups also had comparable rates of symptomatic intracranial hemorrhage, length of stay, and discharge disposition. In the propensity score analysis of 73 matched pairs, EM was comparable to usual care with respect to 90-day functional outcome (OR for higher mRS 0.891, p = 0.7). Conclusions: Mobilization within 24 h resulted in comparable rates of 90-day neurological function, symptomatic intracranial hemorrhage, and hospital length of stay in patients with mild ischemic stroke treated with intravenous thrombolysis. Future trials may further investigate the safety and efficacy of EM in alternate and larger patient cohorts. Full article
(This article belongs to the Special Issue Advances in Novel Treatment and Rehabilitation for Strokes)

Review

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17 pages, 706 KB  
Review
Impact of Stroke Code Activation on Functional Outcomes and the Role of Nursing in Neurorehabilitation: A Systematic Review
by Álvaro Astasio-Picado, Jesus Jurado-Palomo and Clara Fátima Rodriguez-Urbaneja
Neurol. Int. 2025, 17(11), 175; https://doi.org/10.3390/neurolint17110175 - 29 Oct 2025
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Abstract
Introduction: Stroke is one of the leading causes of death and disability worldwide. In this context, early activation of the Stroke Code and a structured neurorehabilitation approach are key determinants of patients’ functional outcomes. Objectives: We aimed to evaluate the impact of Stroke [...] Read more.
Introduction: Stroke is one of the leading causes of death and disability worldwide. In this context, early activation of the Stroke Code and a structured neurorehabilitation approach are key determinants of patients’ functional outcomes. Objectives: We aimed to evaluate the impact of Stroke Code activation on the functional prognosis of patients who have suffered an ischemic stroke, analyzing the time-dependent relationship and the effectiveness of reperfusion therapies. Additionally, we sought to examine the role of nursing in inpatient neurorehabilitation. Methods: A systematic review was conducted following the PRISMA 2020 guidelines. Scientific studies published between 2020 and 2025 were reviewed across five databases: PubMed; Cochrane Library; Dialnet; Web of Science; and Scopus. Eligibility criteria were applied, and validated tools were used to assess methodological quality and risk of bias. Results: Thirteen studies were included, involving a total sample of 80,555 patients. Age; lesion volume; and time to treatment were found to be key prognostic factors. Early implementation of reperfusion therapies (thrombolysis and/or thrombectomy), combined with nursing-led neurorehabilitation interventions, significantly improved neurological status, functional independence, and quality of life. Conclusions: Stroke Code activation has a significant positive influence on functional prognosis. Reducing treatment delays and optimizing reperfusion therapies are critical. Furthermore, the role of nursing in hospital-based neurorehabilitation is essential to support patient recovery and functionality. Full article
(This article belongs to the Special Issue Advances in Novel Treatment and Rehabilitation for Strokes)
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