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Neurology International
Special Issues
Advances in Novel Treatment and Rehabilitation for Strokes
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Advances in Novel Treatment and Rehabilitation for Strokes

A special issue of Neurology International (ISSN 2035-8377).

Deadline for manuscript submissions: 31 July 2025 | Viewed by 407

Special Issue Editors

Dr. Katsuya Sakai

E-Mail Website
Guest Editor
Department of Physical Therapy, Faculty of Health Sciences, Tokyo Metropolitan University, Tokyo 116-8551, Japan
Interests: stroke
Dr. Motoyoshi Morishita

E-Mail Website
Guest Editor
Department of Physical Therapy, Reiwa Health Sciences University, Hukuoka 811-0213, Japan
Interests: dysphagia; community-dwelling older people; oral function; stroke
Dr. Junpei Tanabe

E-Mail Website
Guest Editor
Department Physical Therapy, Hiroshima Cosmopolitan University, Hiroshima, Japan
Interests: stroke; rehabilitation; illusion; action observation therapy; paralysis; unilateral spatial neglect

Special Issue Information

Dear Colleagues,

This Special Issue invites a wide range of studies describing and assessing novel rehabilitation strategies related to gait, higher-brain dysfunction, motor impairment, brain function, and dysphagia in patients who have had a stroke. Despite the advancements in stroke rehabilitation with the development of science and technology, older forms of rehabilitation assessment and treatment are still being used, with few proposals for new strategies which would change existing rehabilitation practices. This Special Issue focuses on rehabilitation assessment methods and treatments, as well as novel rehabilitation proposals.

Dr. Katsuya Sakai
Dr. Motoyoshi Morishita
Dr. Junpei Tanabe
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Neurology International is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stroke
  • rehabilitation
  • therapy
  • assessments
  • gait
  • higher-brain dysfunction
  • motor function
  • brain function
  • dysphagia

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

9 pages, 231 KiB  
Article
Very Early Rehabilitation After Treatment with Intravenous Thrombolysis for Mild Acute Ischemic Stroke
by Rahul R. Karamchandani, Liang Wang, Dale Strong, Alexis A. Mulvaney, Jonathan D. Clemente and Jeremy B. Rhoten
Neurol. Int. 2025, 17(4), 60; https://doi.org/10.3390/neurolint17040060 - 18 Apr 2025
Viewed by 272
Abstract
Background/Objectives: The optimal timing of rehabilitation after acute ischemic stroke is unclear. We studied neurological outcomes and safety of early mobilization (EM) within 24 h for patients receiving intravenous thrombolysis. Methods: This was a retrospective analysis of patients treated at a single Comprehensive [...] Read more.
Background/Objectives: The optimal timing of rehabilitation after acute ischemic stroke is unclear. We studied neurological outcomes and safety of early mobilization (EM) within 24 h for patients receiving intravenous thrombolysis. Methods: This was a retrospective analysis of patients treated at a single Comprehensive Stroke Center from 6/2020–10/2024 with EM versus usual care. Patients were eligible for EM if they were treated with intravenous thrombolysis and had post-treatment National Institutes of Health Stroke Scale scores ≤ 5, and later, ≤10. Ordinal regression was performed to determine factors associated with a 90-day functional outcome benefit in the full cohort. Propensity scores were calculated for matched sample pairs to determine any shift towards better outcomes with EM. Results: Groups of 165 and 73 patients were treated with EM and usual care, respectively. Treatment with EM was not associated with improved 90-day neurological outcome (odds ratio [OR] for higher mRS 0.746, p = 0.265). The groups also had comparable rates of symptomatic intracranial hemorrhage, length of stay, and discharge disposition. In the propensity score analysis of 73 matched pairs, EM was comparable to usual care with respect to 90-day functional outcome (OR for higher mRS 0.891, p = 0.7). Conclusions: Mobilization within 24 h resulted in comparable rates of 90-day neurological function, symptomatic intracranial hemorrhage, and hospital length of stay in patients with mild ischemic stroke treated with intravenous thrombolysis. Future trials may further investigate the safety and efficacy of EM in alternate and larger patient cohorts. Full article
(This article belongs to the Special Issue Advances in Novel Treatment and Rehabilitation for Strokes)
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