Special Issue "Nanoencapsulation Strategies for Active Compounds Delivery"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: 31 December 2020.

Special Issue Editors

Dr. Claudia Carbone
Website
Guest Editor
Università degli Studi di Catania, Department of Drug Sciences, Catania, Italy
Interests: drug delivery systems for pharmaceutical, cosmetic and agro-food applications: design, optimization, preparation and characterization; drug delivery to the brain; ophthalmic drug delivery; dermal/transdermal drug delivery; natural compound delivery; essential oil delivery
Dr. Carla Caddeo
Website
Guest Editor
Università di Cagliari, Dipartimento di Scienze della Vita e dell’Ambiente, Cagliari, Italy
Interests: drug delivery systems for pharmaceutical, cosmetic and agro-food applications: design, optimization, preparation and characterization; dermal/transdermal drug delivery; intestinal drug delivery; oral drug delivery; bioactive natural compound delivery
Prof. Dr. Teresa Musumeci
Website
Guest Editor
Department of Drug Sciences, Università degli Studi di Catania, Catania, Italy
Interests: drug delivery systems for pharmaceutical, cosmetic and agro-food applications: design, optimization, preparation and characterization; nose to brain delivery; ophthalmic drug delivery; new biodegradable polymers for drug delivery systems; nanomedicine for cancer diagnosis and therapy
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Nanoencapsulation strategies represent a hot topic of great interest, since they provide increasing drug therapeutic effectiveness (overcoming solubility, stability and bioavailability problems) of low soluble drugs (BCS class II and IV) and non-Lipinski compounds. Nanoencapsulation promotes drug repurposing (a cost-effective and timesaving identification of novel pharmacological effects of conventional drugs) and the use of natural compounds, a promising reservoir for human health.

The interest in the nanoencapsulation of active molecules also continues due to the need to account for several drawbacks, in particular those related to customization, patient compliance, impact on human health and environment, fields of application (pharmaceutical, cosmetic, agro-food).

This Special Issue invites manuscripts concerning the nanoencapsulation of synthetic drugs, peptides, proteins and natural compounds, with a particular emphasis on their applications in targeted and controlled delivery. Original articles on nanoencapsulation strategies will be considered, including the use of different structures (nanoparticles, vesicles, supramolecular drug delivery systems), materials (lipids, polymers, hybrid nanoparticles, etc), combining drugs encapsulation strategies (dual delivery) and the use of different coating materials. In vitro and in vivo studies are recommended.

Dr. Claudia Carbone
Dr. Carla Caddeo
Dr. Teresa Musumeci
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticles
  • nanocarriers
  • drug delivery systems
  • hybrid nanoparticles
  • coating strategies
  • liposomes
  • dual delivery
  • synthetic drugs
  • natural compounds

Published Papers (3 papers)

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Research

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Open AccessArticle
Ferulic Acid-NLC with Lavandula Essential Oil: A Possible Strategy for Wound-Healing?
Nanomaterials 2020, 10(5), 898; https://doi.org/10.3390/nano10050898 - 08 May 2020
Abstract
Nowadays, an increasing interest in combinatorial drug delivery systems is emerging, highlighting the possibility of exploiting essential oils (EO) for topical applications. This work aimed at developing nanostructured lipid carriers (NLC) for the combined delivery of ferulic acid and Lavandula EO, whose beneficial [...] Read more.
Nowadays, an increasing interest in combinatorial drug delivery systems is emerging, highlighting the possibility of exploiting essential oils (EO) for topical applications. This work aimed at developing nanostructured lipid carriers (NLC) for the combined delivery of ferulic acid and Lavandula EO, whose beneficial effects in wound-healing processes have been widely reported. Homogeneous (polydispersity index, PDI < 0.2) nanoparticles with a small size (<150 nm) and a high encapsulation efficiency (>85%) were obtained. The co-presence of ferulic acid and Lavandula EO, as compared to synthetic isopropyl myristate-based NLC, increased nanoparticles’ stability, due to higher ordering chains, as confirmed by morphological and physicochemical studies. An enhanced cytocompatibility was observed when combining ferulic acid and Lavandula EO, as confirmed by in vitro studies on fibroblasts. Furthermore, the combined delivery of ferulic acid and Lavandula EO significantly promoted cell migration with higher effectiveness in respect to the free drug solution and the carrier without the EO. Taken all together, our results suggest a potential combined effect of the antioxidant ferulic acid and Lavandula EO co-delivered in lipid nanoparticles in promoting cell proliferation and migration, representing a promising strategy in the treatment of wounds. Full article
(This article belongs to the Special Issue Nanoencapsulation Strategies for Active Compounds Delivery)
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Open AccessArticle
Ocular Formulation Based on Palmitoylethanolamide-Loaded Nanostructured Lipid Carriers: Technological and Pharmacological Profile
Nanomaterials 2020, 10(2), 287; https://doi.org/10.3390/nano10020287 - 08 Feb 2020
Cited by 2
Abstract
The present work was aimed for the preparation of a stable nanostructured lipid carrier (NLC) system for the delivery of N-palmitoylethanolamide (PEA) to the back of the eye. PEA is an interesting natural compound showing anti-inflammatory and neuroprotective activities. The limits of PEA [...] Read more.
The present work was aimed for the preparation of a stable nanostructured lipid carrier (NLC) system for the delivery of N-palmitoylethanolamide (PEA) to the back of the eye. PEA is an interesting natural compound showing anti-inflammatory and neuroprotective activities. The limits of PEA (poor solubility and high instability) justify its nanoencapsulation into drug delivery systems. Two different well-known techniques were compared to formulate NLC: the high shear homogenization technique (HSH) and the method based on a combination of HSH technique and ultrasonication (HSH/US). Nanoparticles were evaluated in relation to mean size, homogeneity, surface charge, and physical stability by Turbiscan technology. Retinal distribution of PEA was carried out in a rat eye after single instillation of PEA-NLC ophthalmic formulation. The novel formulation delivered remarkable levels of PEA to the retina. Lastly, topical administration of PEA-NLC ophthalmic formulation was able to significantly inhibits retinal tumor necrosis factor-α (TNF-α) levels in streptozotocin-induced diabetic rats. The present findings suggest that the novel ophthalmic formulation may be useful for the treatment of retinal diseases such as diabetic retinopathy. Clinical studies are in progress to evaluate this possibility. Full article
(This article belongs to the Special Issue Nanoencapsulation Strategies for Active Compounds Delivery)
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Review

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Open AccessReview
Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities
Nanomaterials 2020, 10(5), 847; https://doi.org/10.3390/nano10050847 - 28 Apr 2020
Abstract
Polymer-based nanocapsules have been widely studied as a potential drug delivery system in recent years. Nanocapsules—as one of kind nanoparticle—provide a unique nanostructure, consisting of a liquid/solid core with a polymeric shell. This is of increasing interest in drug delivery applications. In this [...] Read more.
Polymer-based nanocapsules have been widely studied as a potential drug delivery system in recent years. Nanocapsules—as one of kind nanoparticle—provide a unique nanostructure, consisting of a liquid/solid core with a polymeric shell. This is of increasing interest in drug delivery applications. In this review, nanocapsules delivery systems studied in last decade are reviewed, along with nanocapsule formulation, characterizations of physical/chemical/biologic properties and applications. Furthermore, the challenges and opportunities of nanocapsules applications are also proposed. Full article
(This article belongs to the Special Issue Nanoencapsulation Strategies for Active Compounds Delivery)
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